Success Metrics

Clinical Success Rate
78.6%

Based on 11 completed trials

Completion Rate
79%(11/14)
Active Trials
34(56%)
Results Posted
100%(11 trials)
Terminated
3(5%)

Phase Distribution

Ph phase_1
25
41%
Ph phase_3
6
10%
Ph phase_2
29
48%

Phase Distribution

25

Early Stage

29

Mid Stage

6

Late Stage

Phase Distribution60 total trials
Phase 1Safety & dosage
25(41.7%)
Phase 2Efficacy & side effects
29(48.3%)
Phase 3Large-scale testing
6(10.0%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

64.7%

11 of 17 finished

Non-Completion Rate

35.3%

6 ended early

Currently Active

34

trials recruiting

Total Trials

61

all time

Status Distribution
Active(44)
Completed(11)
Terminated(6)

Detailed Status

Recruiting20
Active, not recruiting14
Completed11
Not yet recruiting9
Terminated3
Withdrawn3

Development Timeline

Analytics

Development Status

Total Trials
61
Active
34
Success Rate
78.6%
Most Advanced
Phase 3

Trials by Phase

Phase 125 (41.7%)
Phase 229 (48.3%)
Phase 36 (10.0%)

Trials by Status

completed1118%
not_yet_recruiting915%
active_not_recruiting1423%
recruiting2033%
enrolling_by_invitation12%
terminated35%
withdrawn35%

Recent Activity

Clinical Trials (61)

Showing 20 of 61 trialsScroll for more
NCT05283720Phase 2

A Study to Evaluate Adverse Events and Change in Disease Activity of Subcutaneous (SC) Epcoritamab in Combination With Oral and Intravenous Anti-Neoplastic Agents in Adult Participants With Non-Hodgkin Lymphoma

Recruiting
NCT06890884Phase 2

A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

Recruiting
NCT05954910

A Study to Evaluate the Effectiveness and Safety of Polatuzumab in Real World Clinical Practice Among Adult Chinese Participants With Diffuse Large B-Cell Lymphoma

Active Not Recruiting
NCT06594939Phase 2

Mosunetuzumab and Polatuzumab Vedotin With Split-Dose CHP Chemotherapy for Elderly Patients With Diffuse Large B-Cell Lymphoma

Not Yet Recruiting
NCT06015880Phase 1

Testing the Combination of Anti-cancer Drugs Mosunetuzumab, Polatuzumab Vedotin, and Lenalidomide for the Treatment of Relapsed/Refractory Diffuse Large B-Cell Lymphoma

Recruiting
NCT04884035Phase 1

Study of Safety and Efficacy of Iberdomide (CC-220) and CC-99282 Combined With R-CHOP to Treat Lymphoma

Recruiting
NCT04491370Phase 1

Autologous Stem Cell Transplant Followed by Polatuzumab Vedotin in Patients With B-cell Non-Hodgkin and Hodgkin Lymphoma

Recruiting
NCT05798156Phase 2

Rituximab in Combination With Glofitamab and Polatuzumab Vedotin in Patients With Previously Untreated Aggressive B-cell Lymphoma Ineligible for R-CHOP

Active Not Recruiting
NCT07502872Phase 2

TPG: Tafasitamab, Polatuzumab Vedotin, and Glofitamab as First-line Therapy for Diffuse Large B-cell Lymphoma and High-grade B-cell Lymphoma

Not Yet Recruiting
NCT06047080Phase 3

An Open-Label Study Comparing Glofitamab and Polatuzumab Vedotin + Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone Versus Pola-R-CHP in Previously Untreated Patients With Large B-Cell Lymphoma

Active Not Recruiting
NCT05615636Phase 2

A Phase II Trial of Mosunetuzumab, Polatuzumab, Tafasitamab, and Lenalidomide in Patients With Relapsed B-cell NHL

Recruiting
NCT04970901Phase 1

A Study to Evaluate the Safety and Anti-cancer Activity of Loncastuximab Tesirine in Combination With Other Anti-cancer Agents in Participants With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (LOTIS-7)

Recruiting
NCT05171647Phase 3

A Study Evaluating Efficacy and Safety of Mosunetuzumab in Combination With Polatuzumab Vedotin Compared to Rituximab in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed or Refractory Aggressive B-Cell Non-Hodgkin's Lymphoma

Active Not Recruiting
NCT04231877Phase 1

Polatuzumab Vedotin and Combination Chemotherapy With or Without Glofitamab for the Treatment of Untreated Aggressive Large B-cell Lymphoma

Recruiting
NCT07415980Phase 1

Phase Ib/II Study of Polatuzumab Vedotin in Combination With Rituximab and Chidamide in Newly Diagnosed Elderly Patients With Double-Expressor DLBCL

Not Yet Recruiting
NCT07397832Phase 2

CRP Regimen in Treating Elderly Patients With Previously Untreated Double-Positive DLBCL

Recruiting
NCT03274492Phase 3

A Study Comparing the Efficacy and Safety of Polatuzumab Vedotin With Rituximab-Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab-Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Diffuse Large B-Cell Lymphoma

Active Not Recruiting
NCT05633615Phase 2

Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma

Recruiting
NCT04323956Phase 1

Parsaclisib Plus the Standard Drug Therapy in Patients With Newly Diagnosed, High Risk Diffuse Large B-cell Lymphoma

Active Not Recruiting
NCT06043674Phase 2

Phase 2 Study of Glofitamab Monotherapy & With Polatuzumab Vedotin, Pirtobrutinib, or Atezolizumab in Richter's Transformation

Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
61