Success Metrics

Clinical Success Rate
66.7%

Based on 14 completed trials

Completion Rate
67%(14/21)
Active Trials
6(20%)
Results Posted
121%(17 trials)
Terminated
7(23%)

Phase Distribution

Ph phase_2
9
30%
Ph phase_3
2
7%
Ph phase_1
18
60%

Phase Distribution

18

Early Stage

9

Mid Stage

2

Late Stage

Phase Distribution29 total trials
Phase 1Safety & dosage
18(62.1%)
Phase 2Efficacy & side effects
9(31.0%)
Phase 3Large-scale testing
2(6.9%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

60.9%

14 of 23 finished

Non-Completion Rate

39.1%

9 ended early

Currently Active

6

trials recruiting

Total Trials

30

all time

Status Distribution
Active(6)
Completed(14)
Terminated(9)
Other(1)

Detailed Status

Completed14
Terminated7
Active, not recruiting6
Withdrawn2
unknown1

Development Timeline

Analytics

Development Status

Total Trials
30
Active
6
Success Rate
66.7%
Most Advanced
Phase 3

Trials by Phase

Phase 118 (62.1%)
Phase 29 (31.0%)
Phase 32 (6.9%)

Trials by Status

unknown13%
active_not_recruiting620%
terminated723%
withdrawn27%
completed1447%

Recent Activity

Clinical Trials (30)

Showing 20 of 30 trialsScroll for more
NCT03479268Phase 1

Pevonedistat and Ibrutinib in Treating Participants With Relapsed or Refractory CLL or Non-Hodgkin Lymphoma

Active Not Recruiting
NCT03009240Phase 1

Pevonedistat and Decitabine in Treating Patients With High Risk Acute Myeloid Leukemia

Completed
NCT03965689Phase 2

Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy

Active Not Recruiting
NCT03862157Phase 1

Azacitidine, Venetoclax, and Pevonedistat in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia

Active Not Recruiting
NCT03772925Phase 1

Pevonedistat and Belinostat in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome

Terminated
NCT03330821Phase 1

Pevonedistat, Cytarabine, and Idarubicin in Treating Patients With Acute Myeloid Leukemia

Active Not Recruiting
NCT04175912Phase 2

Testing the Combination of Pevonedistat With Chemotherapy for Bile Duct Cancer of the Liver

Active Not Recruiting
NCT03268954Phase 3

Pevonedistat Plus Azacitidine Versus Single-Agent Azacitidine as First-Line Treatment for Participants With Higher-Risk Myelodysplastic Syndromes (HR MDS), Chronic Myelomonocytic Leukemia (CMML), or Low-Blast Acute Myelogenous Leukemia (AML)

Completed
NCT04266795Phase 2

A Study of Pevonedistat and Venetoclax Combined With Azacitidine to Treat Acute Myeloid Leukemia (AML) in Adults Unable to Receive Intensive Chemotherapy

Completed
NCT03770260Phase 1

Ixazomib and Pevonedistat in Treating Patients With Multiple Myeloma That Has Come Back or Does Not Respond to Treatment

Completed
NCT03813147Phase 1

Pevonedistat, Azacitidine, Fludarabine Phosphate, and Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome

Completed
NCT04090736Phase 3

Study to Compare Azacitidine Plus Pevonedistat Versus Azacitidine in Patients With Acute Myeloid Leukemia Not Eligible for Standard Chemotherapy

Active Not Recruiting
NCT03323034Phase 1

Pevonedistat, Irinotecan, and Temozolomide in Treating Patients With Recurrent or Refractory Solid Tumors or Lymphoma

Completed
NCT03814005Phase 1

A Study of Pevonedistat in People With Blood Cancers or Solid Tumors With Kidney or Liver Problems

Completed
NCT04172844Phase 1

Pevonedistat, Azacitidine (or Decitabine), and Venetoclax for the Treatment of Patients With Acute Myelogenous Leukemia

Terminated
NCT03319537Phase 1

Pevonedistat Alone and in Combination With Chemotherapy in Patients With Mesothelioma

Terminated
NCT03228186Phase 2

Trial of Pevonedistat Plus Docetaxel in Patients With Previously Treated Advanced Non-Small Cell Lung Cancer

Terminated
NCT04712942Phase 2

Treatment of MDS/AML Patients With an Impending Hematological Relapse With AZA or ATA and Pevonedistat

Completed
NCT03745352Phase 2

Pevonedistat With Azacitidine Versus Azacitidine Alone in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

Withdrawn
NCT03330106Phase 1

A Study to Evaluate the Effects of Pevonedistat on the Corrected QT (QTc) Interval in Participants With Advanced Solid Tumors

Completed

Drug Details

Intervention Type
DRUG
Total Trials
30