Success Metrics

Clinical Success Rate
90.9%

Based on 10 completed trials

Completion Rate
91%(10/11)
Active Trials
9(43%)
Results Posted
110%(11 trials)
Terminated
1(5%)

Phase Distribution

Ph phase_2
7
33%
Ph phase_3
6
29%
Ph phase_1
5
24%

Phase Distribution

5

Early Stage

7

Mid Stage

6

Late Stage

Phase Distribution18 total trials
Phase 1Safety & dosage
5(27.8%)
Phase 2Efficacy & side effects
7(38.9%)
Phase 3Large-scale testing
6(33.3%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

90.9%

10 of 11 finished

Non-Completion Rate

9.1%

1 ended early

Currently Active

9

trials recruiting

Total Trials

21

all time

Status Distribution
Active(9)
Completed(10)
Terminated(1)
Other(1)

Detailed Status

Completed10
Recruiting5
Active, not recruiting4
Terminated1
unknown1

Development Timeline

Analytics

Development Status

Total Trials
21
Active
9
Success Rate
90.9%
Most Advanced
Phase 3

Trials by Phase

Phase 15 (27.8%)
Phase 27 (38.9%)
Phase 36 (33.3%)

Trials by Status

active_not_recruiting419%
recruiting524%
completed1048%
terminated15%
unknown15%

Recent Activity

Clinical Trials (21)

Showing 20 of 21 trialsScroll for more
NCT07214298Phase 1

Pegcetacoplan in Combination With Modified FOLFIRINOX for the Treatment of Metastatic Pancreatic Ductal Adenocarcinoma

Recruiting
NCT04572854Phase 2

Study Assessing the Safety and Efficacy of Pegcetacoplan in Post-Transplant Recurrence of C3G or IC-MPGN

Completed
NCT05809531Phase 3

An Open-Label, Nonrandomized, Multicenter Extension Study to Evaluate the Long-term Safety and Efficacy of Pegcetacoplan in Participants With C3 Glomerulopathy or Immune-Complex Membranoproliferative Glomerulonephritis

Active Not Recruiting
NCT04919629Phase 2

APL-2 and Pembrolizumab Versus APL-2, Pembrolizumab and Bevacizumab Versus Bevacizumab Alone for the Treatment of Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer and Malignant Effusion

Recruiting
NCT07020832Phase 3

A Phase 3 Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults at High Risk of Delayed Graft Function (DGF) Following Kidney Allograft Transplantation

Recruiting
NCT06161584

A Prospective, Multicenter, Open-Label, Observational Phase 4 Study to Evaluate Real-World Safety, Tolerability, and Treatment Patterns of Pegcetacoplan (Syfovre) in Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration

Active Not Recruiting
NCT05067127Phase 3

Phase III Study Assessing the Efficacy and Safety of Pegcetacoplan in Patients With C3 Glomerulopathy or Immune-Complex Membranoproliferative Glomerulonephritis

Completed
NCT06722157Phase 2

A Study to Test Whether BI 771716 Helps People With an Advanced Form of Age-related Macular Degeneration (AMD) Called Geographic Atrophy

Active Not Recruiting
NCT05148299Phase 2

A Study of Pegcetacoplan for Patients With Transplant-associated Thrombotic Microangiopathy After Hematopoietic Stem Cell Transplantation

Completed
NCT04729062

C3G/Primary IC-MPGN EAP

Unknown
NCT05096403Phase 3

A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Patients With Cold Agglutinin Disease (CAD)

Completed
NCT04901936Phase 2

A Study of Pegcetacoplan in Pediatric Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Recruiting
NCT05776472

A Real World Effectiveness Study of Pegcetacoplan in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Recruiting
NCT03531255Phase 3

Pegcetacoplan Long Term Safety and Efficacy Extension Study

Active Not Recruiting
NCT03500549Phase 3

Study to Evaluate the Efficacy and Safety of APL-2 in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Completed
NCT02588833Phase 1

Pilot Study to Assess Safety, Preliminary Efficacy and Pharmacokinetics of S.C. Pegcetacoplan (APL-2) in PNH Subjects.

Completed
NCT02264639Phase 1

A Phase I Study to Assess the Safety of Pegcetacoplan (APL-2) as an Add-On to Standard of Care in Subjects With PNH

Completed
NCT03593200Phase 2

A Phase IIa Study to Assess the Safety, Efficacy, and Pharmacokinetics of Subcutaneously Administered Pegcetacoplan (APL-2) in Subjects With PNH

Completed
NCT02461771Phase 1

Assessment of Safety, Tolerability and Pharmacokinetics of Intravitreal Pegcetacoplan (APL-2) for Patients With Wet AMD

Completed
NCT02503332Phase 2

Study of Pegcetacoplan (APL-2) Therapy in Patients With Geographic Atrophy

Completed

Drug Details

Intervention Type
DRUG
Total Trials
21