Success Metrics

Clinical Success Rate
91.7%

Based on 11 completed trials

Completion Rate
92%(11/12)
Active Trials
8(36%)
Results Posted
100%(11 trials)
Terminated
1(5%)

Phase Distribution

Ph phase_1
5
23%
Ph phase_4
1
5%
Ph phase_2
7
32%
Ph phase_3
6
27%

Phase Distribution

5

Early Stage

7

Mid Stage

7

Late Stage

Phase Distribution19 total trials
Phase 1Safety & dosage
5(26.3%)
Phase 2Efficacy & side effects
7(36.8%)
Phase 3Large-scale testing
6(31.6%)
Phase 4Post-market surveillance
1(5.3%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

91.7%

11 of 12 finished

Non-Completion Rate

8.3%

1 ended early

Currently Active

8

trials recruiting

Total Trials

22

all time

Status Distribution
Active(8)
Completed(11)
Terminated(1)
Other(2)

Detailed Status

Completed11
Recruiting5
Active, not recruiting3
Terminated1
Suspended1
unknown1

Development Timeline

Analytics

Development Status

Total Trials
22
Active
8
Success Rate
91.7%
Most Advanced
Phase 4

Trials by Phase

Phase 15 (26.3%)
Phase 27 (36.8%)
Phase 36 (31.6%)
Phase 41 (5.3%)

Trials by Status

terminated15%
completed1150%
suspended15%
recruiting523%
active_not_recruiting314%
unknown15%

Recent Activity

Clinical Trials (22)

Showing 20 of 22 trialsScroll for more
NCT07746895Phase 4

Real-World Effectiveness and Safety of Pegcetacoplan in Patients With C3G or IC-MPG: A Multi-Country Study

Recruiting
NCT05776472

A Real World Effectiveness Study of Pegcetacoplan in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Recruiting
NCT04901936Phase 2

A Study of Pegcetacoplan in Pediatric Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Recruiting
NCT07020832Phase 3

Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults at High Risk of Delayed Graft Function (DGF) Following Kidney Allograft Transplantation

Suspended
NCT07214298Phase 1

Pegcetacoplan in Combination With Modified FOLFIRINOX for the Treatment of Metastatic Pancreatic Ductal Adenocarcinoma

Recruiting
NCT03531255Phase 3

Pegcetacoplan Long Term Safety and Efficacy Extension Study

Completed
NCT06161584

A Prospective, Multicenter, Open-Label, Observational Phase 4 Study to Evaluate Real-World Safety, Tolerability, and Treatment Patterns of Pegcetacoplan (Syfovre) in Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration

Active Not Recruiting
NCT06722157Phase 2

A Study to Test Whether BI 771716 Helps People With an Advanced Form of Age-related Macular Degeneration (AMD) Called Geographic Atrophy

Active Not Recruiting
NCT04572854Phase 2

Study Assessing the Safety and Efficacy of Pegcetacoplan in Post-Transplant Recurrence of C3G or IC-MPGN

Completed
NCT05809531Phase 3

An Open-Label, Nonrandomized, Multicenter Extension Study to Evaluate the Long-term Safety and Efficacy of Pegcetacoplan in Participants With C3 Glomerulopathy or Immune-Complex Membranoproliferative Glomerulonephritis

Active Not Recruiting
NCT04919629Phase 2

APL-2 and Pembrolizumab Versus APL-2, Pembrolizumab and Bevacizumab Versus Bevacizumab Alone for the Treatment of Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer and Malignant Effusion

Recruiting
NCT05067127Phase 3

Phase III Study Assessing the Efficacy and Safety of Pegcetacoplan in Patients With C3 Glomerulopathy or Immune-Complex Membranoproliferative Glomerulonephritis

Completed
NCT05148299Phase 2

A Study of Pegcetacoplan for Patients With Transplant-associated Thrombotic Microangiopathy After Hematopoietic Stem Cell Transplantation

Completed
NCT04729062

C3G/Primary IC-MPGN EAP

Unknown
NCT05096403Phase 3

A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Patients With Cold Agglutinin Disease (CAD)

Completed
NCT03500549Phase 3

Study to Evaluate the Efficacy and Safety of APL-2 in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Completed
NCT02588833Phase 1

Pilot Study to Assess Safety, Preliminary Efficacy and Pharmacokinetics of S.C. Pegcetacoplan (APL-2) in PNH Subjects.

Completed
NCT02264639Phase 1

A Phase I Study to Assess the Safety of Pegcetacoplan (APL-2) as an Add-On to Standard of Care in Subjects With PNH

Completed
NCT03593200Phase 2

A Phase IIa Study to Assess the Safety, Efficacy, and Pharmacokinetics of Subcutaneously Administered Pegcetacoplan (APL-2) in Subjects With PNH

Completed
NCT02503332Phase 2

Study of Pegcetacoplan (APL-2) Therapy in Patients With Geographic Atrophy

Completed

Drug Details

Intervention Type
DRUG
Total Trials
22