Success Metrics

Clinical Success Rate
92.3%

Based on 12 completed trials

Completion Rate
92%(12/13)
Active Trials
0(0%)
Results Posted
75%(9 trials)
Terminated
1(8%)

Phase Distribution

Ph phase_2
5
38%
Ph phase_1
6
46%
Ph phase_3
2
15%

Phase Distribution

6

Early Stage

5

Mid Stage

2

Late Stage

Phase Distribution13 total trials
Phase 1Safety & dosage
6(46.2%)
Phase 2Efficacy & side effects
5(38.5%)
Phase 3Large-scale testing
2(15.4%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

92.3%

12 of 13 finished

Non-Completion Rate

7.7%

1 ended early

Currently Active

0

trials recruiting

Total Trials

13

all time

Status Distribution
Completed(12)
Terminated(1)

Detailed Status

Completed12
Terminated1

Development Timeline

Analytics

Development Status

Total Trials
13
Active
0
Success Rate
92.3%
Most Advanced
Phase 3

Trials by Phase

Phase 16 (46.2%)
Phase 25 (38.5%)
Phase 32 (15.4%)

Trials by Status

terminated18%
completed1292%

Recent Activity

Clinical Trials (13)

Showing 13 of 13 trials
NCT03896750Phase 1

Single-Dose Study to Evaluate the PKs of Pretomanid in Participants With Renal Impairment Compared to Participants With Normal Renal Function

Completed
NCT02333799Phase 3

A Phase 3 Trial Assessing Safety and Efficacy of B-Pa-L in Participants With DR-TB

Completed
NCT02422524Phase 1

Pretomanid in Adults With Hepatic Impairment

Terminated
NCT02256696Phase 2

Assessing PA-824 for Tuberculosis (the APT Trial)

Completed
NCT01571414Phase 1

Evaluating the Safety and Drug Interaction of PA-824, an Investigational Tuberculosis Medication, Together With Efavirenz, Ritonavir-Boosted Lopinavir, or Rifampin

Completed
NCT00944021Phase 2

Evaluation of Early Bactericidal Activity in Pulmonary Tuberculosis (CL-010)

Completed
NCT01768273Phase 1

Evaluation of the Pharmacokinetic Interaction Between PA-824 and Midazolam

Completed
NCT02193776Phase 2

A Phase 2 to Evaluate the Efficacy, Safety and Tolerability of Combinations of Bedaquiline, Moxifloxacin, PA-824 and Pyrazinamide in Adult Subjects With Drug-Sensitive or Multi Drug-Resistant Pulmonary Tuberculosis.

Completed
NCT02342886Phase 3

Shortening Treatment by Advancing Novel Drugs

Completed
NCT03202693Phase 1

A Study of the Safety, Tolerability, and Absorption, Metabolism, and Excretion of PA-824 in Healthy Adult Male Subjects.

Completed
NCT00567840Phase 2

PA-824-CL-007: Phase IIa Evaluation of Early Bactericidal Activity in Pulmonary Tuberculosis

Completed
NCT01215851Phase 2

Evaluation of Early Bactericidal Activity in Pulmonary Tuberculosis With(J-M-Pa-Z) (NC-001)

Completed
NCT01674218Phase 1

Effect of PA-824 and of PA-824 Plus Moxifloxacin on the QTc Interval in Healthy Volunteers

Completed

All 13 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
13