Success Metrics

Clinical Success Rate
100.0%

Based on 5 completed trials

Completion Rate
100%(5/5)
Active Trials
6(46%)
Results Posted
60%(3 trials)

Phase Distribution

Ph phase_1
5
38%
Ph phase_2
6
46%
Ph early_phase_1
1
8%

Phase Distribution

6

Early Stage

6

Mid Stage

0

Late Stage

Phase Distribution12 total trials
Early Phase 1First-in-human
1(8.3%)
Phase 1Safety & dosage
5(41.7%)
Phase 2Efficacy & side effects
6(50.0%)

Highest Phase Reached

Phase 2

Trial Status & Enrollment

Completion Rate

83.3%

5 of 6 finished

Non-Completion Rate

16.7%

1 ended early

Currently Active

6

trials recruiting

Total Trials

13

all time

Status Distribution
Active(6)
Completed(5)
Terminated(1)
Other(1)

Detailed Status

Completed5
Recruiting4
Active, not recruiting2
Withdrawn1
unknown1

Development Timeline

Analytics

Development Status

Total Trials
13
Active
6
Success Rate
100.0%
Most Advanced
Phase 2

Trials by Phase

Early Phase 11 (8.3%)
Phase 15 (41.7%)
Phase 26 (50.0%)

Trials by Status

withdrawn18%
completed538%
active_not_recruiting215%
recruiting431%
unknown18%

Recent Activity

Clinical Trials (13)

Showing 13 of 13 trials
NCT04005690Early Phase 1

Targeted Pathway Inhibition in Patients With Pancreatic Cancer

Recruiting
NCT05549661Phase 1

Onvansertib for the Treatment of Recurrent or Refractory Chronic Myelomonocytic Leukemia and Myelodysplastic Syndrome/MPN Overlap Neoplasms

Recruiting
NCT05383196Phase 1

Onvansertib + Paclitaxel In TNBC

Active Not Recruiting
NCT06106308Phase 2

Study of Onvansertib in Combination With FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab Versus FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab for First-Line Treatment of Metastatic Colorectal Cancer in Adult Participants With a KRAS or NRAS Mutation

Active Not Recruiting
NCT04752696Phase 2

Onvansertib in Combination With Nanoliposomal Irinotecan, Leucovorin, and Fluorouracil for Second-Line Treatment of Participants With Metastatic Pancreatic Ductal Adenocarcinoma

Completed
NCT05450965Phase 2

Study of PLK1 Inhibitor, Onvansertib, in Relapsed Small Cell Lung Cancer

Recruiting
NCT03829410Phase 1

Onvansertib in Combination With FOLFIRI and Bevacizumab for Second Line Treatment of Metastatic Colorectal Cancer Patients With a KRAS Mutation

Completed
NCT06736717Phase 1

Onvansertib in Combination With NALIRIFOX for First Line Treatment of Advanced Pancreatic Cancer

Recruiting
NCT05593328Phase 2

Study of Onvansertib in Combination With FOLFIRI and Bevacizumab Versus FOLFIRI and Bevacizumab for Second Line Treatment of Metastatic Colorectal Cancer in Participants With a Kirsten Rat Sarcoma Virus Gene (KRAS) or Neuroblastoma-RAS (NRAS) Mutation

Completed
NCT03414034Phase 2

Onvansertib in Combination With Abiraterone and Prednisone in Adult Patients With Metastatic Castration-Resistant Prostate Cancer

Completed
NCT06398587Phase 2

Onvansertib in Combination With Gemcitabine and Nab-paclitaxel for the Treatment of Patients With Locally-advanced, Unresectable, or Metastatic Pancreatic Ductal Adenocarcinoma

Withdrawn
NCT04446793

Expanded Access of Onvansertib With FOLFIRI and Bevacizumab for the Second-Line Treatment of Participants With KRAS-Mutated Metastatic Colorectal Cancer

Unknown
NCT03303339Phase 1

Onvansertib in Combination With Either Low-dose Cytarabine or Decitabine in Adult Patients With Acute Myeloid Leukemia (AML)

Completed

All 13 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
13