Success Metrics

Clinical Success Rate
90.0%

Based on 9 completed trials

Completion Rate
90%(9/10)
Active Trials
10(50%)
Results Posted
44%(4 trials)
Terminated
1(5%)

Phase Distribution

Ph phase_1
11
55%
Ph phase_3
3
15%
Ph phase_2
6
30%

Phase Distribution

11

Early Stage

6

Mid Stage

3

Late Stage

Phase Distribution20 total trials
Phase 1Safety & dosage
11(55.0%)
Phase 2Efficacy & side effects
6(30.0%)
Phase 3Large-scale testing
3(15.0%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

90.0%

9 of 10 finished

Non-Completion Rate

10.0%

1 ended early

Currently Active

10

trials recruiting

Total Trials

20

all time

Status Distribution
Active(10)
Completed(9)
Terminated(1)

Detailed Status

Completed9
Active, not recruiting7
Recruiting3
Terminated1

Development Timeline

Analytics

Development Status

Total Trials
20
Active
10
Success Rate
90.0%
Most Advanced
Phase 3

Trials by Phase

Phase 111 (55.0%)
Phase 26 (30.0%)
Phase 33 (15.0%)

Trials by Status

terminated15%
active_not_recruiting735%
completed945%
recruiting315%

Recent Activity

Clinical Trials (20)

Showing 20 of 20 trials
NCT06622941Phase 2

Study to ONO-4538 in Patients With Rhabdoid Tumor

Recruiting
NCT06936943Phase 2

ONO-4538 Study in Patients With Richter's Transformation

Recruiting
NCT03155061Phase 1

Study of ONO-4578 With and Without ONO-4538 in Subjects Advanced or Metastatic Solid Tumors

Active Not Recruiting
NCT06535009Phase 1

Study of ONO-7914 Alone and in Combination With ONO-4538 in Patients With Solid Tumors

Terminated
NCT04566380Phase 2

ONO-4538 Phase II Rollover Study (ONO-4538-98)

Recruiting
NCT06532331Phase 1

A PhaseⅠStudy of ONO-7475 in Combination With ONO-4538 and Gemcitabine Plus Nab-paclitaxel (GnP), the Standard of Care, and ONO-7475 in Combination With GnP in Patients With Pancreatic Cancer

Active Not Recruiting
NCT02582125Phase 2

ONO-4538 Study in Patients With Advanced Non-Small Cell Lung Cancer

Completed
NCT06538207Phase 1

An Open-label, Uncontrolled Study of ONO-4578 and ONO-4538 in Combination With Standard-of-care Modified FOLFIRINOX (mFFX) or Gemcitabine Plus Nab-paclitaxel (GnP) Therapy as First-line Treatment in Patients With Metastatic Pancreatic Cancer

Completed
NCT02175017Phase 2

ONO-4538 Study in Patients With Advanced Non-Small Cell Lung Cancer

Completed
NCT06532344Phase 1

An Open-label, Uncontrolled Study of ONO-7913 and ONO-4538 in Combination With Modified FOLFIRINOX Therapy, the Standard of Care, as First-line Treatment in Patients With Metastatic Pancreatic Cancer

Active Not Recruiting
NCT06540261Phase 1

The Study of ONO-7913, ONO-4538 and the Standard of Care as First-line Treatment in Patients Colorectal Cancer

Active Not Recruiting
NCT05144854Phase 3

A Study to Evaluate the Efficacy and Safety of ONO-4538 in Combination With Ipilimumab and Chemotherapy in Chemotherapy-naïve Participants With HER2-negative Unresectable Advanced or Recurrent Gastric Cancer (Including Esophagogastric Junction Cancer)

Active Not Recruiting
NCT06547385Phase 1

Study of ONO-4578 and XELOX/FOLFOX Plus Bevacizumab in Colorectal Cancer

Active Not Recruiting
NCT06542731Phase 1

An Open-label, Uncontrolled Study of ONO-4578 and ONO-4538 in Combination With Standard-of-care Docetaxel and Ramucirumab as Second-line Therapy in Patients With Advanced or Recurrent Non-small Cell Lung Cancer

Active Not Recruiting
NCT02261285Phase 1

ONO-4538 Phase I Study in Patients With Solid Tumor

Completed
NCT03117049Phase 3

Study of ONO-4538 in Non-Squamous Non-Small Cell Lung Cancer (TASUKI-52)

Completed
NCT02267343Phase 3

Study of ONO-4538 in Unresectable Advanced or Recurrent Gastric Cancer

Completed
NCT02746796Phase 2

Study of ONO-4538 in Gastric Cancer

Completed
NCT02261298Phase 1

ONO-4538 Phase I Study in Patients With Solid Tumor

Completed
NCT00836888Phase 1

ONO-4538 Phase I Study in Patients With Advanced Malignant Solid Tumors in Japan

Completed

All 20 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
20