Success Metrics

Clinical Success Rate
76.0%

Based on 19 completed trials

Completion Rate
76%(19/25)
Active Trials
1(3%)
Results Posted
21%(4 trials)
Terminated
6(21%)

Phase Distribution

Ph phase_2
9
31%
Ph phase_3
1
3%
Ph not_applicable
2
7%
Ph phase_1
17
59%

Phase Distribution

17

Early Stage

9

Mid Stage

1

Late Stage

Phase Distribution29 total trials
Phase 1Safety & dosage
17(58.6%)
Phase 2Efficacy & side effects
9(31.0%)
Phase 3Large-scale testing
1(3.4%)
N/ANon-phased studies
2(6.9%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

67.9%

19 of 28 finished

Non-Completion Rate

32.1%

9 ended early

Currently Active

1

trials recruiting

Total Trials

29

all time

Status Distribution
Active(1)
Completed(19)
Terminated(9)

Detailed Status

Completed19
Terminated6
Withdrawn3
Recruiting1

Development Timeline

Analytics

Development Status

Total Trials
29
Active
1
Success Rate
76.0%
Most Advanced
Phase 3

Trials by Phase

Phase 117 (58.6%)
Phase 29 (31.0%)
Phase 31 (3.4%)
N/A2 (6.9%)

Trials by Status

recruiting13%
withdrawn310%
terminated621%
completed1966%

Recent Activity

Clinical Trials (29)

Showing 20 of 29 trialsScroll for more
NCT05052957Phase 2

hSTAR GBM (Hematopoetic Stem Cell (HPC) Rescue for GBM)

Recruiting
NCT01269424Phase 1

BG & TMZ Therapy of Glioblastoma Multiforme

Completed
NCT00669669Phase 1

O6-Benzylguanine-Mediated Tumor Sensitization With Chemoprotected Autologous Stem Cell in Treating Patients With Malignant Gliomas

Terminated
NCT00275002Phase 2

O6-Benzylguanine and Temozolomide in Treating Young Patients With Recurrent or Progressive Gliomas or Brain Stem Tumors

Completed
NCT02343666Phase 1

HIV-Resistant Gene Modified Stem Cells and Chemotherapy in Treating Patients With Lymphoma With HIV Infection

Withdrawn
NCT00002971Phase 1

O(6)-Benzylguanine in Treating Patients With Malignant Glioma

Completed
NCT00961220Phase 1

O6-Benzylguanine and Topical Carmustine in Treating Patients With Early-Stage IA-IIA Cutaneous T-Cell Lymphoma

Completed
NCT00436436Phase 2

O(6)-Benzylguanine and Temozolomide in Treating Patients With Glioblastoma Multiforme That Did Not Respond to Previous Temozolomide and Radiation Therapy

Terminated
NCT01769911Not Applicable

Genetically Modified Peripheral Blood Stem Cell Transplant in Treating Patients With HIV-Associated Non-Hodgkin or Hodgkin Lymphoma

Withdrawn
NCT00020150Phase 1

Temozolomide and O6-benzylguanine in Treating Children With Solid Tumors

Completed
NCT00005081Phase 2

Carmustine Plus O6-benzylguanine in Treating Patients With Recurrent or Progressive Glioma

Completed
NCT00003766Phase 1

O6-benzylguanine Followed by Surgery in Treating Patients With Solid Tumors That Can Be Removed During Surgery

Completed
NCT00253487Not Applicable

Combination Chemotherapy and Radiation Therapy in Treating Younger Patients Who Are Undergoing an Autologous Stem Cell Transplant for Newly Diagnosed Gliomas

Completed
NCT00052780Phase 1

Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors

Completed
NCT00005066Phase 2

O6-benzylguanine and Carmustine in Treating Patients With Recurrent, Metastatic, or Locally Advanced Soft Tissue Sarcoma

Completed
NCT00006474Phase 1

Temozolomide and O6-benzylguanine in Treating Patients With Newly Diagnosed, Recurrent, or Progressive Anaplastic Glioma

Completed
NCT00046878Phase 2

Carmustine and O(6)-Benzylguanine in Treating Patients With Newly Diagnosed Supratentorial Glioblastoma Multiforme

Withdrawn
NCT00003348Phase 1

Carmustine Plus O(6)-Benzylguanine in Treating Patients With Recurrent or Progressive Gliomas of the Brain

Completed
NCT00005961Phase 2

O6-benzylguanine and Carmustine in Treating Patients With Unresectable Locally Recurrent or Metastatic Melanoma

Completed
NCT00003765Phase 1

O6-benzylguanine and Carmustine in Treating Children With Refractory CNS Tumors

Completed

Drug Details

Intervention Type
DRUG
Total Trials
29