Success Metrics

Clinical Success Rate
87.5%

Based on 14 completed trials

Completion Rate
88%(14/16)
Active Trials
4(17%)
Results Posted
57%(8 trials)
Terminated
2(9%)

Phase Distribution

Ph phase_1
5
22%
Ph phase_3
6
26%
Ph not_applicable
1
4%
Ph phase_2
4
17%
Ph phase_4
1
4%

Phase Distribution

5

Early Stage

4

Mid Stage

7

Late Stage

Phase Distribution17 total trials
Phase 1Safety & dosage
5(29.4%)
Phase 2Efficacy & side effects
4(23.5%)
Phase 3Large-scale testing
6(35.3%)
Phase 4Post-market surveillance
1(5.9%)
N/ANon-phased studies
1(5.9%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

87.5%

14 of 16 finished

Non-Completion Rate

12.5%

2 ended early

Currently Active

4

trials recruiting

Total Trials

23

all time

Status Distribution
Active(4)
Completed(14)
Terminated(2)
Other(3)

Detailed Status

Completed14
unknown3
Terminated2
Active, not recruiting2
Recruiting2

Development Timeline

Analytics

Development Status

Total Trials
23
Active
4
Success Rate
87.5%
Most Advanced
Phase 4

Trials by Phase

Phase 15 (29.4%)
Phase 24 (23.5%)
Phase 36 (35.3%)
Phase 41 (5.9%)
N/A1 (5.9%)

Trials by Status

unknown313%
terminated29%
completed1461%
active_not_recruiting29%
recruiting29%

Recent Activity

Clinical Trials (23)

Showing 20 of 23 trialsScroll for more
NCT07047144Phase 2

A Study to Evaluate How Apitegromab Works in Subjects Who Are Less Than 2 Years Old and Have Spinal Muscular Atrophy

Recruiting
NCT06555419Phase 1

A Study to Find Out How Nusinersen is Processed in the Body When Given Through the ThecaFlex DRx™ System in Adult and Pediatric Participants With Spinal Muscular Atrophy (PIERRE-PK)

Recruiting
NCT04729907Phase 3

A Study to Learn About the Long-Term Safety of Higher Doses of Nusinersen (BIIB058) Given as Injections to Participants With Spinal Muscular Atrophy (SMA) Who Took Part in an Earlier Nusinersen Trial (ONWARD)

Active Not Recruiting
NCT02386553Phase 2

A Study of Multiple Doses of Nusinersen (ISIS 396443) Delivered to Infants With Genetically Diagnosed and Presymptomatic Spinal Muscular Atrophy

Completed
NCT04488133Phase 4

A Study to Learn About the Effect of Nusinersen (BIIB058) Given as Injections to Children With Spinal Muscular Atrophy (SMA) Who Were Previously Treated With Onasemnogene Abeparvovec (RESPOND)

Completed
NCT04089566Phase 3

Study of Nusinersen (BIIB058) in Participants With Spinal Muscular Atrophy

Completed
NCT05067790Phase 3

A Study to Learn About the Effect of Higher Doses of Nusinersen (BIIB058) Given as Injections to Participants With Spinal Muscular Atrophy (SMA) Who Were Previously Treated With Risdiplam (ASCEND)

Active Not Recruiting
NCT04576494Not Applicable

Study of the Functional Effects of Nusinersen in 5q-spinal Muscular Amyotrophy Adults (SMA Type 2 or 3 Forms)

Completed
NCT02594124Phase 3

A Study for Participants With Spinal Muscular Atrophy (SMA) Who Previously Participated in Nusinersen (ISIS 396443) Investigational Studies

Completed
NCT03878030

Effect of Nusinersen on Adults With Spinal Muscular Atrophy

Completed
NCT04587492

Metabolomics of Children With SMA

Completed
NCT05187260

Antisense Oligonucleotide for Spinal Muscular Atrophy

Unknown
NCT04591678

Adults With SMA Treated With Nusinersen

Completed
NCT01703988Phase 1

An Open-label Safety, Tolerability and Dose-Range Finding Study of Multiple Doses of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy

Completed
NCT02865109

Expanded Access Program (EAP) for Nusinersen in Participants With Infantile-onset (Consistent With Type 1) Spinal Muscular Atrophy (SMA)

Unknown
NCT04825119

Hyperkinetic Movements in Patients With Disease of Motor Neurons and Their Response to Treatment With Nusinersen

Unknown
NCT01494701Phase 1

An Open-label Safety, Tolerability, and Dose-range Finding Study of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy (SMA)

Completed
NCT02462759Phase 2

A Study to Assess the Safety and Tolerability of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy (SMA).

Terminated
NCT02292537Phase 3

A Study to Assess the Efficacy and Safety of Nusinersen (ISIS 396443) in Participants With Later-onset Spinal Muscular Atrophy (SMA)

Completed
NCT02193074Phase 3

A Study to Assess the Efficacy and Safety of Nusinersen (ISIS 396443) in Infants With Spinal Muscular Atrophy

Terminated

Drug Details

Intervention Type
DRUG
Total Trials
23