Success Metrics

Clinical Success Rate
77.8%

Based on 7 completed trials

Completion Rate
78%(7/9)
Active Trials
4(17%)
Results Posted
14%(1 trials)
Terminated
2(9%)

Phase Distribution

Ph early_phase_1
1
4%
Ph phase_2
5
22%
Ph phase_1
17
74%

Phase Distribution

18

Early Stage

5

Mid Stage

0

Late Stage

Phase Distribution23 total trials
Early Phase 1First-in-human
1(4.3%)
Phase 1Safety & dosage
17(73.9%)
Phase 2Efficacy & side effects
5(21.7%)

Highest Phase Reached

Phase 2

Trial Status & Enrollment

Completion Rate

77.8%

7 of 9 finished

Non-Completion Rate

22.2%

2 ended early

Currently Active

4

trials recruiting

Total Trials

23

all time

Status Distribution
Active(7)
Completed(7)
Terminated(2)
Other(7)

Detailed Status

unknown7
Completed7
Not yet recruiting3
Recruiting3
Terminated2
Active, not recruiting1

Development Timeline

Analytics

Development Status

Total Trials
23
Active
4
Success Rate
77.8%
Most Advanced
Phase 2

Trials by Phase

Early Phase 11 (4.3%)
Phase 117 (73.9%)
Phase 25 (21.7%)

Trials by Status

not_yet_recruiting313%
unknown730%
terminated29%
active_not_recruiting14%
completed730%
recruiting313%

Recent Activity

Clinical Trials (23)

Showing 20 of 23 trialsScroll for more
NCT00720785Phase 1

Natural Killer Cells and Bortezomib to Treat Cancer

Completed
NCT07411599Phase 1

Dual Administration Of Intraperitoneal And Intravenous TROP2-Directed CAR-NK With TGF-Beta Receptor 2 (TGFBR2) Knock Out (KO) Therapy For Colorectal Cancer-Related Peritoneal Carcinomatosis: A Phase 1/2 Trial ("Chip-CRC Trial")

Recruiting
NCT07551778Phase 1

Allogeneic NK Cell Therapy Combined With Standard Maintenance Treatment in Advanced Solid Tumors

Not Yet Recruiting
NCT05834244Phase 1

A Phase Ib Trial of Azacitidine, Venetoclax and Allogeneic NK Cells for Acute Myeloid Leukemia (ADVENT-AML)

Recruiting
NCT07579208Phase 1

A Phase1 Clinical Trial Evaluating Locoregional Delivery Of Engineered NK Cells Containing IL13Ra And EGFvIII Chimeric Antigen Receptor (CAR), IL-21 Secretion And Deleted TGF-BetaR2 And NR3C1 In Recurrent Glioblastoma

Not Yet Recruiting
NCT02573896Phase 1

Immunotherapy of Relapsed Refractory Neuroblastoma With Expanded NK Cells

Active Not Recruiting
NCT05385705Phase 1

A Study of Allogenic Natural Killer Cells in Combination With Trastuzumab and Pertuzumab in Adult Patients With Refractory Metastatic Her2 Positive Breast Cancer. NK-ACT-BC_2020

Terminated
NCT02650648Phase 1

Humanized Anti-GD2 Antibody Hu3F8 and Allogeneic Natural Killer Cells for High-Risk Neuroblastoma

Completed
NCT04254419Phase 1

Phase 1 Study of Locoregional Injections of Ex Vivo Expanded Natural Killer Cells

Recruiting
NCT05319249Phase 1

Natural Killer Cell Immunotherapy in Combination With PARP-inhibition in Acute Myeloid Leukemia

Not Yet Recruiting
NCT04280224Phase 1

NK Cells Treatment for COVID-19

Completed
NCT02280525Phase 1

Cord Blood Natural Killer (NK) Cells in Leukemia/Lymphoma

Completed
NCT02229266Phase 2

Randomised Controlled Phase-2 Trial to Determine the Efficacy of Adoptive Immunotherapy With NK Cells in High-risk AML

Terminated
NCT01370213Phase 2

NK Cell Based Non-Myeloablative Transplantation in Acute Myeloid Diseases

Completed
NCT03662477Early Phase 1

Effect of NK Cell Immunotherapy on Advanced Lung Adenocarcinoma Adenocarcinoma With EGFR Mutation

Unknown
NCT02718859Phase 1

Combination of Irreversible Electroporation and NK Immunotherapy for Advanced Pancreatic Cancer

Completed
NCT02123836Phase 1

Natural Killer Cells in Acute Leukaemia and Myelodysplastic Syndrome

Unknown
NCT03410368Phase 2

NK Cell-based Immunotherapy as Maintenance Therapy for Small-Cell Lung Cancer.

Unknown
NCT02734524Phase 2

A Clinical Research of NK Cell Infusion Combined With Chemotherapy in the Treatment of Non-small Cell Lung Cancer

Unknown
NCT02118285Phase 1

Intraperitoneal Natural Killer Cells and INCB024360 for Recurrent Ovarian, Fallopian Tube, and Primary Peritoneal Cancer

Completed

Drug Details

Intervention Type
BIOLOGICAL
Total Trials
23