Success Metrics

Clinical Success Rate
87.2%

Based on 41 completed trials

Completion Rate
87%(41/47)
Active Trials
9(13%)
Results Posted
37%(15 trials)
Terminated
6(9%)

Phase Distribution

Ph not_applicable
21
30%
Ph early_phase_1
5
7%
Ph phase_1
6
9%
Ph phase_2
11
16%
Ph phase_3
8
11%
Ph phase_4
17
24%

Phase Distribution

11

Early Stage

11

Mid Stage

25

Late Stage

Phase Distribution68 total trials
Early Phase 1First-in-human
5(7.4%)
Phase 1Safety & dosage
6(8.8%)
Phase 2Efficacy & side effects
11(16.2%)
Phase 3Large-scale testing
8(11.8%)
Phase 4Post-market surveillance
17(25.0%)
N/ANon-phased studies
21(30.9%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

78.8%

41 of 52 finished

Non-Completion Rate

21.2%

11 ended early

Currently Active

9

trials recruiting

Total Trials

70

all time

Status Distribution
Active(11)
Completed(41)
Terminated(11)
Other(7)

Detailed Status

Completed41
Recruiting9
unknown7
Terminated6
Withdrawn5
Enrolling by invitation1

Development Timeline

Analytics

Development Status

Total Trials
70
Active
9
Success Rate
87.2%
Most Advanced
Phase 4

Trials by Phase

Early Phase 15 (7.4%)
Phase 16 (8.8%)
Phase 211 (16.2%)
Phase 38 (11.8%)
Phase 417 (25.0%)
N/A21 (30.9%)

Trials by Status

completed4159%
recruiting913%
enrolling_by_invitation11%
not_yet_recruiting11%
terminated69%
unknown710%
withdrawn57%

Recent Activity

9 active trials
Showing 5 of 70
recruitingphase_1

NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits

NCT02994433
recruitingearly_phase_1

Nitrous Oxide Neuroimaging

NCT06702631
completedphase_1

Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery

NCT06867068
recruitingphase_4

Self-Adjusted Nitrous Oxide: A Feasibility Study in the Setting of Vasectomy

NCT05895383
completedphase_4

The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial

NCT00430989
View all 70 trials

Clinical Trials (70)

Showing 20 of 70 trialsScroll for more
NCT02994433Phase 1

NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits

Recruiting
NCT06702631Early Phase 1

Nitrous Oxide Neuroimaging

Recruiting
NCT06867068Phase 1

Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery

Completed
NCT05895383Phase 4

Self-Adjusted Nitrous Oxide: A Feasibility Study in the Setting of Vasectomy

Recruiting
NCT00430989Phase 4

The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial

Completed
NCT03736538Phase 1

Nitrous Oxide- Suicidal Ideation

Enrolling By Invitation
NCT07245628Early Phase 1

A Trial of Self-Adjusted Nitrous Versus Placebo During Office Vasectomy

Recruiting
NCT05890898Not Applicable

Virtual Reality vs Nitrous Oxide in Pediatric Dentistry

Completed
NCT01581450Phase 1

Hyperalgesia and Pain

Completed
NCT03826693Phase 2

Efficacy of Nitrous Oxide in OCD: Pilot Study

Recruiting
NCT05383495Phase 3

Anxiolysis for Laceration Repair in Children

Recruiting
NCT06118567Phase 2

Effect of Nitrous Oxide on Aggression.

Recruiting
NCT03869736Phase 2

Nitrous Oxide for the Treatment of Major Depressive Disorder

Completed
NCT06661005Early Phase 1

Nitrous Oxide for Pain Management During In-Office Gynecology Procedures

Terminated
NCT06498908Phase 3

Intracervical Balloon Placement With Nitrous Oxide Administration

Recruiting
NCT06430489Phase 2

Treatment of Suicidal Ideation in the Emergency Department Using Nitrous Oxide

Not Yet Recruiting
NCT01622335Not Applicable

Effect OF Nitrous Oxide On Acute Pain and Opioid Consumption, and Chronic Pain After Hysterectomy

Withdrawn
NCT05510141Not Applicable

Virtual Reality Games in Pediatric Surgery

Recruiting
NCT04305158Early Phase 1

Colonoscopy Using Nitrous Oxide- A Pilot Study in the USA

Completed
NCT04749043Not Applicable

Virtual Reality Compared to Nitrous Oxide for Labor Analgesia

Completed

Drug Details

Intervention Type
DRUG
Total Trials
70