Success Metrics

Clinical Success Rate
71.4%

Based on 45 completed trials

Completion Rate
71%(45/63)
Active Trials
56(37%)
Results Posted
80%(36 trials)
Terminated
18(12%)

Phase Distribution

Ph phase_1
43
28%
Ph phase_2
79
52%
Ph phase_3
16
10%
Ph phase_4
4
3%
Ph early_phase_1
3
2%

Phase Distribution

46

Early Stage

79

Mid Stage

20

Late Stage

Phase Distribution145 total trials
Early Phase 1First-in-human
3(2.1%)
Phase 1Safety & dosage
43(29.7%)
Phase 2Efficacy & side effects
79(54.5%)
Phase 3Large-scale testing
16(11.0%)
Phase 4Post-market surveillance
4(2.8%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

60.8%

45 of 74 finished

Non-Completion Rate

39.2%

29 ended early

Currently Active

56

trials recruiting

Total Trials

153

all time

Status Distribution
Active(60)
Completed(45)
Terminated(29)
Other(19)

Detailed Status

Completed45
Active, not recruiting34
Recruiting22
unknown19
Terminated18
Withdrawn11

Development Timeline

Analytics

Development Status

Total Trials
153
Active
56
Success Rate
71.4%
Most Advanced
Phase 4

Trials by Phase

Early Phase 13 (2.1%)
Phase 143 (29.7%)
Phase 279 (54.5%)
Phase 316 (11.0%)
Phase 44 (2.8%)

Trials by Status

recruiting2214%
unknown1912%
withdrawn117%
not_yet_recruiting43%
terminated1812%
active_not_recruiting3422%
completed4529%

Recent Activity

Clinical Trials (153)

Showing 20 of 153 trialsScroll for more
NCT03748641Phase 3

A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Participants With Metastatic Prostate Cancer

Active Not Recruiting
NCT05406700Early Phase 1

Niraparib In Recurrent IDH 1/2 Gliomas

Active Not Recruiting
NCT03768063Phase 3

A Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study

Active Not Recruiting
NCT03586661Phase 1

Niraparib and Copanlisib in Treating Patients With Recurrent Endometrial, Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Completed
NCT04992013Phase 2

Niraparib in Tumors Metastatic to the CNS

Active Not Recruiting
NCT06915025Phase 3

Phase 3 Trial Evaluating the Safety & Efficacy of IMNN-001 Administered in Combination w/ Standard NACT & Adjuvant Chemotherapy in Newly Diagnosed Patients w/ Advanced EOC, Fallopian Tube or Primary Peritoneal Cancer

Recruiting
NCT04037254Phase 1

Testing the Addition of a New Anti-Cancer Drug, Niraparib, to the Usual Treatment (Hormone and Radiation Therapy) for Prostate Cancer With a High Chance of Recurring

Completed
NCT04577833Phase 1

A Study of Comparative Formulations of Niraparib and Abiraterone Acetate (AA) in Men With Prostate Cancer

Active Not Recruiting
NCT04497844Phase 3

A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-Mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC)

Active Not Recruiting
NCT06388733Phase 3

A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma

Active Not Recruiting
NCT04926324Phase 1

A Safety Study Adding Niraparib and Dostarlimab to Radiation Therapy for Rectal Cancers

Terminated
NCT04641247Phase 2

A Long-term Treatment Extension Study of Niraparib in Participants Who Completed a Prior GlaxoSmithKline/TESARO-sponsored Niraparib Study

Recruiting
NCT04947254Phase 2

Androgen Ablation Therapy With or Without Niraparib After Radiation Therapy for the Treatment of High-Risk Localized or Locally Advanced Prostate Cancer

Recruiting
NCT03016338Phase 2

Study of Niraparib and TSR-042 in Recurrent Endometrial Cancer

Active Not Recruiting
NCT06412120Phase 4

Study Evaluating Safety, Tolerability, and Metabolism of Niraparib

Recruiting
NCT04475939Phase 3

Placebo-controlled Study Comparing Niraparib Plus Pembrolizumab Versus Placebo Plus Pembrolizumab as Maintenance Therapy in Participants With Advanced/Metastatic Non-Small Cell Lung Cancer

Completed
NCT05694715Phase 1

Combination Therapy in Cancers With Mutations in DNA Repair Genes

Recruiting
NCT04837209Phase 2

Radiation, Immunotherapy and PARP Inhibitor in Triple Negative Breast Cancer

Active Not Recruiting
NCT03945721Phase 1

A Phase I Study of Niraparib Administered Concurrently With Postoperative RT in Triple Negative Breast Cancer Patients

Active Not Recruiting
NCT04592237Phase 2

Cabazitaxel, Carboplatin, and Cetrelimab Followed by Niraparib With or Without Cetrelimab for the Treatment of Aggressive Variant Metastatic Prostate Cancer

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
153