Success Metrics

Clinical Success Rate
69.2%

Based on 45 completed trials

Completion Rate
69%(45/65)
Active Trials
54(36%)
Results Posted
82%(37 trials)
Terminated
20(13%)

Phase Distribution

Ph phase_4
4
3%
Ph early_phase_1
3
2%
Ph phase_1
43
28%
Ph phase_2
79
52%
Ph phase_3
15
10%

Phase Distribution

46

Early Stage

79

Mid Stage

19

Late Stage

Phase Distribution144 total trials
Early Phase 1First-in-human
3(2.1%)
Phase 1Safety & dosage
43(29.9%)
Phase 2Efficacy & side effects
79(54.9%)
Phase 3Large-scale testing
15(10.4%)
Phase 4Post-market surveillance
4(2.8%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

59.2%

45 of 76 finished

Non-Completion Rate

40.8%

31 ended early

Currently Active

54

trials recruiting

Total Trials

152

all time

Status Distribution
Active(58)
Completed(45)
Terminated(31)
Other(18)

Detailed Status

Completed45
Active, not recruiting32
Recruiting22
Terminated20
unknown18
Withdrawn11

Development Timeline

Analytics

Development Status

Total Trials
152
Active
54
Success Rate
69.2%
Most Advanced
Phase 4

Trials by Phase

Early Phase 13 (2.1%)
Phase 143 (29.9%)
Phase 279 (54.9%)
Phase 315 (10.4%)
Phase 44 (2.8%)

Trials by Status

completed4530%
active_not_recruiting3221%
recruiting2214%
unknown1812%
not_yet_recruiting43%
withdrawn117%
terminated2013%

Recent Activity

Clinical Trials (152)

Showing 20 of 152 trialsScroll for more
NCT06747845Phase 2

Maintenance Niraparib Plus Ipilimumab in Patients With Metastatic Pancreatic Adenocarcinoma Whose Disease Has Not Progressed on Platinum-Based Chemotherapy

Recruiting
NCT06141265Phase 2

Niraparib Maintenance in HRD-Positive Advanced Ovarian Cancer Following Front-Line Chemotherapy + Bevacizumab

Recruiting
NCT04577833Phase 1

A Study of Comparative Formulations of Niraparib and Abiraterone Acetate (AA) in Men With Prostate Cancer

Active Not Recruiting
NCT03748641Phase 3

A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Participants With Metastatic Prostate Cancer

Active Not Recruiting
NCT04584255Phase 2

Niraparib + Dostarlimab In BRCA Mutated Breast Cancer

Active Not Recruiting
NCT03891615Phase 1

Niraparib in Combination With Osimertinib in EGFR-Mutated Advanced Lung Cancer

Terminated
NCT06915025Phase 3

Phase 3 Trial Evaluating the Safety & Efficacy of IMNN-001 Administered in Combination w/ Standard NACT & Adjuvant Chemotherapy in Newly Diagnosed Patients w/ Advanced EOC, Fallopian Tube or Primary Peritoneal Cancer

Recruiting
NCT06433219Phase 2

Tuvusertib Combined With Niraparib or Lartesertib in Participants With Epithelial Ovarian Cancer (DDRiver EOC 302)

Completed
NCT04592237Phase 2

Cabazitaxel, Carboplatin, and Cetrelimab Followed by Niraparib With or Without Cetrelimab for the Treatment of Aggressive Variant Metastatic Prostate Cancer

Active Not Recruiting
NCT03651206Phase 2

Recurrent Ovarian CarcinoSarcoma Anti-pd-1 Niraparib

Recruiting
NCT04493060Phase 2

Niraparib and Dostarlimab for the Treatment of Germline or Somatic BRCA1/2 and PALB2 Mutated Metastatic Pancreatic Cancer

Completed
NCT05515575Phase 2

A Study of Niraparib in People With Soft Tissue Sarcoma Who Have Changes in Their Tumor DNA

Active Not Recruiting
NCT06682780Phase 1

A Phase I/II Study of LM-2417 in Subjects With Advanced Solid Tumours

Recruiting
NCT04673448Phase 1

Niraparib and TSR-042 for the Treatment of BRCA-Mutated Unresectable or Metastatic Breast, Pancreas, Ovary, Fallopian Tube, or Primary Peritoneal Cancer

Active Not Recruiting
NCT04170153Phase 1

Tuvusertib (M1774) in Participants With Metastatic or Locally Advanced Unresectable Solid Tumors (DDRiver Solid Tumors 301)

Active Not Recruiting
NCT06412120Phase 4

Study Evaluating Safety, Tolerability, and Metabolism of Niraparib

Recruiting
NCT03869190Phase 1

Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatments and Combinations in Patients With Urothelial Carcinoma (MORPHEUS-UC)

Terminated
NCT05406700Early Phase 1

Niraparib In Recurrent IDH 1/2 Gliomas

Active Not Recruiting
NCT03768063Phase 3

A Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study

Active Not Recruiting
NCT03586661Phase 1

Niraparib and Copanlisib in Treating Patients With Recurrent Endometrial, Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Completed

Drug Details

Intervention Type
DRUG
Total Trials
152