Success Metrics

Clinical Success Rate
71.7%

Based on 43 completed trials

Completion Rate
72%(43/60)
Active Trials
57(37%)
Results Posted
79%(34 trials)
Terminated
17(11%)

Phase Distribution

Ph early_phase_1
3
2%
Ph phase_1
43
28%
Ph phase_2
79
52%
Ph phase_3
16
10%
Ph phase_4
4
3%

Phase Distribution

46

Early Stage

79

Mid Stage

20

Late Stage

Phase Distribution145 total trials
Early Phase 1First-in-human
3(2.1%)
Phase 1Safety & dosage
43(29.7%)
Phase 2Efficacy & side effects
79(54.5%)
Phase 3Large-scale testing
16(11.0%)
Phase 4Post-market surveillance
4(2.8%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

60.6%

43 of 71 finished

Non-Completion Rate

39.4%

28 ended early

Currently Active

57

trials recruiting

Total Trials

153

all time

Status Distribution
Active(61)
Completed(43)
Terminated(28)
Other(21)

Detailed Status

Completed43
Active, not recruiting33
Recruiting24
unknown21
Terminated17
Withdrawn11

Development Timeline

Analytics

Development Status

Total Trials
153
Active
57
Success Rate
71.7%
Most Advanced
Phase 4

Trials by Phase

Early Phase 13 (2.1%)
Phase 143 (29.7%)
Phase 279 (54.5%)
Phase 316 (11.0%)
Phase 44 (2.8%)

Trials by Status

active_not_recruiting3322%
not_yet_recruiting43%
recruiting2416%
terminated1711%
completed4328%
unknown2114%
withdrawn117%

Recent Activity

Clinical Trials (153)

Showing 20 of 153 trialsScroll for more
NCT04313504Phase 2

Study Evaluating the Efficacy of Niraparib and Dostarlimab (TSR-042) in Recurrent/Metastatic HNSCC

Completed
NCT06915025Phase 3

Phase 3 Trial Evaluating the Safety & Efficacy of IMNN-001 Administered in Combination w/ Standard NACT & Adjuvant Chemotherapy in Newly Diagnosed Patients w/ Advanced EOC, Fallopian Tube or Primary Peritoneal Cancer

Recruiting
NCT04194554Phase 1

A Multi-Center Trial of Androgen Suppression With Abiraterone Acetate, Leuprolide, PARP Inhibition and Stereotactic Body Radiotherapy in Prostate Cancer

Active Not Recruiting
NCT04475939Phase 3

Placebo-controlled Study Comparing Niraparib Plus Pembrolizumab Versus Placebo Plus Pembrolizumab as Maintenance Therapy in Participants With Advanced/Metastatic Non-Small Cell Lung Cancer

Completed
NCT03768063Phase 3

A Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study

Active Not Recruiting
NCT06077877Phase 1

A Study to Investigate the Safety, Tolerability, Pharmacokinetics (PK), and Preliminary Anticancer Activity of GSK4524101 Alone or With Niraparib in Participants With Solid Tumors

Active Not Recruiting
NCT06412120Phase 4

Study Evaluating Safety, Tolerability, and Metabolism of Niraparib

Recruiting
NCT04701307Phase 2

Niraparib and Dostarlimab for the Treatment of Small Cell Lung Cancer and Other High-Grade Neuroendocrine Carcinomas

Active Not Recruiting
NCT04577833Phase 1

A Study of Comparative Formulations of Niraparib and Abiraterone Acetate (AA) in Men With Prostate Cancer

Active Not Recruiting
NCT04497844Phase 3

A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-Mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC)

Active Not Recruiting
NCT05021562

A Study of Niraparib in Patients With Ovarian Cancer in Clinical Practice

Completed
NCT03748641Phase 3

A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Participants With Metastatic Prostate Cancer

Active Not Recruiting
NCT05183984Phase 2

Niraparib With beVAcizumab After Complete cytoreductioN in Patients With ovArian Cancer

Recruiting
NCT06388733Phase 3

A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma

Recruiting
NCT05870761Phase 2

Combination Niraparib and Dostarlimab Therapy for Recurrent or Persistent Uterine Serous Carcinoma

Active Not Recruiting
NCT05601440Phase 2

Liquid-biopsy Informed Platform Trial to Evaluate CDK4/6-inhibitor Resistant ER+/HER2- Metastatic Breast Cancer

Recruiting
NCT03601923Phase 2

Niraparib in Patients With Pancreatic Cancer

Completed
NCT05198804Phase 1

A Study of Azenosertib (ZN-c3) and Niraparib in Subjects With Platinum-Resistant Ovarian Cancer

Completed
NCT05694715Phase 1

Combination Therapy in Cancers With Mutations in DNA Repair Genes

Recruiting
NCT04037254Phase 1

Testing the Addition of a New Anti-Cancer Drug, Niraparib, to the Usual Treatment (Hormone and Radiation Therapy) for Prostate Cancer With a High Chance of Recurring

Completed

Drug Details

Intervention Type
DRUG
Total Trials
153