Success Metrics

Clinical Success Rate
85.4%

Based on 35 completed trials

Completion Rate
85%(35/41)
Active Trials
15(22%)
Results Posted
74%(26 trials)
Terminated
6(9%)

Phase Distribution

Ph phase_2
30
43%
Ph phase_3
3
4%
Ph phase_1
31
45%

Phase Distribution

31

Early Stage

30

Mid Stage

3

Late Stage

Phase Distribution64 total trials
Phase 1Safety & dosage
31(48.4%)
Phase 2Efficacy & side effects
30(46.9%)
Phase 3Large-scale testing
3(4.7%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

76.1%

35 of 46 finished

Non-Completion Rate

23.9%

11 ended early

Currently Active

15

trials recruiting

Total Trials

69

all time

Status Distribution
Active(18)
Completed(35)
Terminated(11)
Other(5)

Detailed Status

Completed35
Recruiting11
Terminated6
unknown5
Withdrawn5
Active, not recruiting4

Development Timeline

Analytics

Development Status

Total Trials
69
Active
15
Success Rate
85.4%
Most Advanced
Phase 3

Trials by Phase

Phase 131 (48.4%)
Phase 230 (46.9%)
Phase 33 (4.7%)

Trials by Status

completed3551%
recruiting1116%
active_not_recruiting46%
terminated69%
unknown57%
not_yet_recruiting34%
withdrawn57%

Recent Activity

Clinical Trials (69)

Showing 20 of 69 trialsScroll for more
NCT01042379Phase 2

I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

Recruiting
NCT04374305Phase 2

Innovative Trial for Understanding the Impact of Targeted Therapies in NF2-Related Schwannomatosis (INTUITT-NF2)

Recruiting
NCT03919292Phase 1

Neratinib + Valproate in Advanced Solid Tumors, w/Expansion Cohort in Ras-Mutated Ca

Recruiting
NCT03377387Phase 1

Capecitabine 7/7 Schedule With Neratinib in Patients With Metastatic HER2-Positive Breast Cancer

Active Not Recruiting
NCT04886531Phase 2

Trial of Pre-operative Neratinib and Endocrine Therapy With Trastuzumab in ER-Positive, HER-2 Positive Breast Cancers

Recruiting
NCT03101748Phase 1

Neratinib and Paclitaxel With or Without Pertuzumab and Trastuzumab Before Combination Chemotherapy in Treating Patients With Metastatic or Locally Advanced Breast Cancer

Terminated
NCT06109467Phase 2

Neratinib In Combination With Chemotherapy/Trastuzumab/Pembrolizumab In HER2 Gastroesophageal Cancer

Recruiting
NCT03289039Phase 2

Neratinib +/- Fulvestrant in HER2+, ER+ Metastatic Breast Cancer

Terminated
NCT05933395Phase 2

Genetically-informed Therapy for ER+ Breast Cancer Post-CDK4/6 Inhibitor

Recruiting
NCT03065387Phase 1

Neratinib and Everolimus, Palbociclib, or Trametinib in Treating Participants With Refractory and Advanced or Metastatic Solid Tumors With EGFR Mutation/Amplification, HER2 Mutation/Amplification, or HER3/4 Mutation or KRAS Mutation

Active Not Recruiting
NCT02932280Phase 1

Safety and Dose Finding Study of Neratinib in Children and Young Adults With Cancer That Has Returned or Not Responded to Treatment

Active Not Recruiting
NCT02977780Phase 2

INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)

Recruiting
NCT05919108Phase 2

Neoadjuvant Neratinib in Stage I-III HER2-Mutated Lobular Breast Cancers

Recruiting
NCT07152782Phase 2

T-DXd With or Without Neratinib for HER2 Positive Breast Cancer With Brain Metastasis

Not Yet Recruiting
NCT04388384

Real-life Pan-HER-blockade With Neratinib

Completed
NCT03094052Phase 2

Incidence and Severity of Diarrhea in Patients With HER2 Positive Breast Cancer Treated With Trastuzumab and Neratinib

Completed
NCT05243641Phase 1

Neratinib and Capmatinib Combination (Phase Ib/II) in Metastatic Breast Cancer and Inflammatory Breast Cancer Patients With Abnormal HER-family and c-Met Pathway Activity as Measured by the CELsignia Signaling Analysis Test

Terminated
NCT05615818Phase 3

Personalized Medicine for Advanced Biliary Cancer Patients

Recruiting
NCT05252988Phase 2

Three Antidiarrheal Strategies in HER2+/HR+ Early Breast Cancer Patients Treated With Extended Adjuvant Neratinib

Active Not Recruiting
NCT06813079Phase 2

Using Tumor Models to Determine Treatments

Not Yet Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
69