Success Metrics

Clinical Success Rate
100.0%

Based on 7 completed trials

Completion Rate
100%(7/7)
Active Trials
12(60%)
Results Posted
0%(0 trials)

Phase Distribution

Ph phase_3
3
15%
Ph phase_1
11
55%
Ph phase_2
6
30%

Phase Distribution

11

Early Stage

6

Mid Stage

3

Late Stage

Phase Distribution20 total trials
Phase 1Safety & dosage
11(55.0%)
Phase 2Efficacy & side effects
6(30.0%)
Phase 3Large-scale testing
3(15.0%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

100.0%

7 of 7 finished

Non-Completion Rate

0.0%

0 ended early

Currently Active

12

trials recruiting

Total Trials

20

all time

Status Distribution
Active(13)
Completed(7)

Detailed Status

Completed7
Recruiting7
Active, not recruiting5
Not yet recruiting1

Development Timeline

Analytics

Development Status

Total Trials
20
Active
12
Success Rate
100.0%
Most Advanced
Phase 3

Trials by Phase

Phase 111 (55.0%)
Phase 26 (30.0%)
Phase 33 (15.0%)

Trials by Status

completed735%
not_yet_recruiting15%
active_not_recruiting525%
recruiting735%

Recent Activity

Clinical Trials (20)

Showing 20 of 20 trials
NCT04728893Phase 2

Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)

Recruiting
NCT07194980Phase 2

Nemtabrutinib and Lisocabtagene Maraleucel for the Treatment of Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Recruiting
NCT05347225Phase 1

A Study of Nemtabrutinib (MK-1026) in China Participants With Relapsed or Refractory Hematologic Malignancies (MK-1026-005)

Active Not Recruiting
NCT07557056Phase 2

Nemtabrutinib and Venetoclax for the Treatment of Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Not Yet Recruiting
NCT06136559Phase 3

A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)

Recruiting
NCT07232589Phase 1

A Study of the Effect of Diltiazem on the Plasma Levels of Nemtabrutinib (MK-1026-022)

Active Not Recruiting
NCT06863402Phase 2

Nemtabrutinib and Pembrolizumab for the Treatment of Richter Transformation, Diffuse Large B-cell Lymphoma Subtype

Recruiting
NCT05624554Phase 3

A Study of Nemtabrutinib vs Chemoimmunotherapy for Participants With Previously Untreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) Without TP53 Aberrations (MK-1026-008, BELLWAVE-008)

Active Not Recruiting
NCT05947851Phase 3

A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010).

Recruiting
NCT06572618Phase 2

Nemtabrutinib With Rituximab for the Treatment of Patients With Mantle Cell Lymphoma

Recruiting
NCT05458297Phase 2

A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006)

Active Not Recruiting
NCT06442436Phase 1

A Study of Nemtabrutinib in Participants With Moderate Hepatic Impairment (MK-1026-015)

Recruiting
NCT05673460Phase 1

A Clinical Study of Nemtabrutinib in Japanese Participants With Hematological Malignancies (MK-1026-002)

Completed
NCT03162536Phase 1

A Study of Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001)

Active Not Recruiting
NCT06772818Phase 1

A Study to Evaluate the Effect of Food on Nemtabrutinib (MK-1026) in Healthy Participants (MK-1026-017)

Completed
NCT06772805Phase 1

A Study to Evaluate the Effect of Food on Nemtabrutinib (MK-1026) in Healthy Participants (MK-1026-016)

Completed
NCT06698016Phase 1

A Study of the Effect of Efavirenz on the Plasma Levels of Nemtabrutinib (MK-1026-014)

Completed
NCT06688045Phase 1

A Study of the Effects of Itraconazole on the Plasma Levels of Nemtabrutinib (MK-1026-013)

Completed
NCT06625827Phase 1

A Study of the Effect of Nemtabrutinib (MK-1026) on the Plasma Levels of Digoxin in Healthy Participants (MK-1026-012)

Completed
NCT06586671Phase 1

A Study to Compare Forms of Nemtabrutinib (MK-1026) in Healthy Adult Participants (MK-1026-007)

Completed

All 20 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
20