Success Metrics

Clinical Success Rate
78.6%

Based on 11 completed trials

Completion Rate
79%(11/14)
Active Trials
3(17%)
Results Posted
118%(13 trials)
Terminated
3(17%)

Phase Distribution

Ph phase_1
8
44%
Ph phase_3
2
11%
Ph phase_2
8
44%

Phase Distribution

8

Early Stage

8

Mid Stage

2

Late Stage

Phase Distribution18 total trials
Phase 1Safety & dosage
8(44.4%)
Phase 2Efficacy & side effects
8(44.4%)
Phase 3Large-scale testing
2(11.1%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

73.3%

11 of 15 finished

Non-Completion Rate

26.7%

4 ended early

Currently Active

3

trials recruiting

Total Trials

18

all time

Status Distribution
Active(3)
Completed(11)
Terminated(4)

Detailed Status

Completed11
Terminated3
Active, not recruiting3
Withdrawn1

Development Timeline

Analytics

Development Status

Total Trials
18
Active
3
Success Rate
78.6%
Most Advanced
Phase 3

Trials by Phase

Phase 18 (44.4%)
Phase 28 (44.4%)
Phase 32 (11.1%)

Trials by Status

terminated317%
active_not_recruiting317%
completed1161%
withdrawn16%

Recent Activity

Clinical Trials (18)

Showing 18 of 18 trials
NCT02496663Phase 1

Osimertinib and Necitumumab in Treating Patients With EGFR-Mutant Stage IV or Recurrent Non-small Cell Lung Cancer Who Have Progressed on a Previous EGFR Tyrosine Kinase Inhibitor

Active Not Recruiting
NCT04285671Phase 1

Necitumumab and Trastuzumab in Combination With Osimertinib for the Treatment of Refractory Epidermal Growth Factor Receptor (EGFR)-Mutated Stage IV Non-small Cell Lung Cancer

Active Not Recruiting
NCT00981058Phase 3

First-line Treatment of Participants With Stage IV Squamous Non-Small Cell Lung Cancer With Necitumumab and Gemcitabine-Cisplatin

Completed
NCT03944772Phase 2

Phase 2 Platform Study in Patients With Advanced Non-Small Lung Cancer Who Progressed on First-Line Osimertinib Therapy (ORCHARD)

Active Not Recruiting
NCT03387111Phase 1

QUILT-3.090: NANT Squamous Cell Carcinoma (SCC) Vaccine: Subjects With SCC Who Have Progressed

Terminated
NCT02789345Phase 1

A Study of Ramucirumab (LY3009806) or Necitumumab (LY3012211) Plus Osimertinib in Participants With Lung Cancer

Completed
NCT03054038Phase 1

Afatinib and Necitumumab in Patients With EGFR Mutation Positive Advanced or Metastatic Non-small Cell Lung Cancer

Terminated
NCT00982111Phase 3

First-line Treatment of Patients With Stage IV Nonsquamous Non-Small Cell Lung Cancer With Necitumumab (IMC-11F8) and Pemetrexed-Cisplatin

Completed
NCT02443337Phase 2

A Study of LY3023414 and Necitumumab in Squamous Lung Cancer

Terminated
NCT02392507Phase 2

A Study of Nab-Paclitaxel and Carboplatin Plus Necitumumab (LY3012211) in Participants With Stage IV Squamous NSCLC

Completed
NCT02451930Phase 1

A Study of the Combination of Necitumumab (LY3012211) and Pembrolizumab (MK3475) in Participants With NSCLC

Completed
NCT02411591Phase 1

A Study of Necitumumab and Abemaciclib in Participants With Non-Small Cell Lung Cancer (NSCLC)

Completed
NCT01763788Phase 1

A Study of Necitumumab in the First-Line Treatment of Stage IV Squamous Non-Small Cell Lung Cancer (NSCLC)

Completed
NCT01606748Phase 2

A Drug-Interaction Study of Necitumumab (IMC-11F8) in Combination With Gemcitabine-Cisplatin

Completed
NCT02941601Phase 2

A Study of Gemcitabine-Carboplatin Plus Necitumumab (LY3012211) in Chemotherapy-Naïve Participants With Locally Advanced or Metastatic Squamous Non-Small Cell Lung Cancer (NSCLC)

Withdrawn
NCT01769391Phase 2

A Study of Necitumumab and Chemotherapy in Participants With Stage IV Squamous Non-Small Cell Lung Cancer

Completed
NCT01624467Phase 2

A Study of Necitumumab Monotherapy and the QT/QTc Interval in Patient With Advanced Solid Tumors

Completed
NCT01788566Phase 2

A Study of Gemcitabine-Cisplatin Chemotherapy Plus Necitumumab in the First-Line Treatment of Participants With Squamous Lung Cancer

Completed

All 18 trials loaded

Drug Details

Intervention Type
BIOLOGICAL
Total Trials
18