Success Metrics

Clinical Success Rate
77.8%

Based on 7 completed trials

Completion Rate
78%(7/9)
Active Trials
11(42%)
Results Posted
71%(5 trials)
Terminated
2(8%)

Phase Distribution

Ph phase_3
2
8%
Ph phase_1
17
65%
Ph phase_2
5
19%

Phase Distribution

17

Early Stage

5

Mid Stage

2

Late Stage

Phase Distribution24 total trials
Phase 1Safety & dosage
17(70.8%)
Phase 2Efficacy & side effects
5(20.8%)
Phase 3Large-scale testing
2(8.3%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

58.3%

7 of 12 finished

Non-Completion Rate

41.7%

5 ended early

Currently Active

11

trials recruiting

Total Trials

26

all time

Status Distribution
Active(12)
Completed(7)
Terminated(5)
Other(2)

Detailed Status

Active, not recruiting11
Completed7
Withdrawn3
Terminated2
unknown2
Not yet recruiting1

Development Timeline

Analytics

Development Status

Total Trials
26
Active
11
Success Rate
77.8%
Most Advanced
Phase 3

Trials by Phase

Phase 117 (70.8%)
Phase 25 (20.8%)
Phase 32 (8.3%)

Trials by Status

not_yet_recruiting14%
completed727%
withdrawn312%
terminated28%
unknown28%
active_not_recruiting1142%

Recent Activity

Clinical Trials (26)

Showing 20 of 26 trialsScroll for more
NCT02079740Phase 1

Trametinib and Navitoclax in Treating Patients With Advanced or Metastatic Solid Tumors

Active Not Recruiting
NCT05222984Phase 1

Navitoclax, Venetoclax, and Decitabine for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia Previously Treated With Venetoclax

Active Not Recruiting
NCT01989585Phase 1

Testing the Addition of Navitoclax to the Combination of Dabrafenib and Trametinib in People Who Have BRAF Mutant Melanoma

Active Not Recruiting
NCT04472598Phase 3

Study of Oral Navitoclax Tablet In Combination With Oral Ruxolitinib Tablet When Compared With Oral Ruxolitinib Tablet To Assess Change In Spleen Volume In Adult Participants With Myelofibrosis

Completed
NCT05455294Phase 1

Combination Navitoclax, Venetoclax and Decitabine for Advanced Myeloid Neoplasms

Active Not Recruiting
NCT03222609Phase 2

A Study Evaluating Tolerability and Efficacy of Navitoclax Alone or in Combination With Ruxolitinib in Participants With Myelofibrosis

Completed
NCT04468984Phase 3

Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet Versus Best Available Therapy to Assess Change in Spleen Volume in Adult Participants With Relapsed/Refractory Myelofibrosis

Active Not Recruiting
NCT05564650Phase 1

Navitoclax in Relapsed or Refractory High-Risk Myelodysplastic Syndrome

Active Not Recruiting
NCT05192889Phase 1

Trial Treating Relapsed Acute Lymphoblastic Leukemia With Venetoclax and Navitoclax

Active Not Recruiting
NCT04454658Phase 1

Safety and Tolerability Study of Oral ABBV-744 Tablet Alone or in Combination With Oral Ruxolitinib Tablet or Oral Navitoclax Tablet in Adult Participants With Myelofibrosis

Active Not Recruiting
NCT04041050Phase 1

A Study Evaluating Safety and Tolerability, and Pharmacokinetics of Navitoclax Monotherapy and in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasm

Active Not Recruiting
NCT05215405

Expanded Access Program of Venetoclax and Navitoclax for Pediatric Patients with Relapsed or Refractory ALL or LL

Unknown
NCT02143401Phase 1

Navitoclax and Sorafenib Tosylate in Treating Patients With Relapsed or Refractory Solid Tumors

Completed
NCT05358639Phase 1

Combination of Olaparib and Navitoclax in Women with HGSC and TNBC

Active Not Recruiting
NCT02520778Phase 1

Osimertinib and Navitoclax in Treating Patients With EGFR-Positive Previously Treated Advanced or Metastatic Non-small Cell Lung Cancer

Completed
NCT05864742Phase 2

Genetically Risk-Stratified Venetoclax, Ibrutinib, Rituximab (± Navitoclax) in Relapsed/Refractory Mantle Cell Lymphoma

Active Not Recruiting
NCT05740449Phase 1

HEM-iSMART-A: Decitabine / Venetoclax and Navitoclax in Pediatric Patients With Relapsed or Refractory Hematological Malignancies

Withdrawn
NCT06210750Phase 2

Adding Targeted Drugs to Usual Chemotherapy for Adults With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (T-ALL) and T-Cell Lymphoblastic Lymphoma (T-LBL)

Withdrawn
NCT03592576

Expanded Access to Navitoclax

Unknown
NCT03366103Phase 1

Navitoclax and Vistusertib in Treating Patients With Relapsed Small Cell Lung Cancer and Other Solid Tumors

Terminated

Drug Details

Intervention Type
BIOLOGICAL
Total Trials
26