Success Metrics

Clinical Success Rate
84.9%

Based on 107 completed trials

Completion Rate
85%(107/126)
Active Trials
16(9%)
Results Posted
45%(48 trials)
Terminated
19(11%)

Phase Distribution

Ph phase_2
59
33%
Ph phase_3
28
16%
Ph phase_4
21
12%
Ph early_phase_1
7
4%
Ph not_applicable
30
17%
Ph phase_1
32
18%

Phase Distribution

39

Early Stage

59

Mid Stage

49

Late Stage

Phase Distribution177 total trials
Early Phase 1First-in-human
7(4.0%)
Phase 1Safety & dosage
32(18.1%)
Phase 2Efficacy & side effects
59(33.3%)
Phase 3Large-scale testing
28(15.8%)
Phase 4Post-market surveillance
21(11.9%)
N/ANon-phased studies
30(16.9%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

81.7%

107 of 131 finished

Non-Completion Rate

18.3%

24 ended early

Currently Active

16

trials recruiting

Total Trials

178

all time

Status Distribution
Active(21)
Completed(107)
Terminated(24)
Other(26)

Detailed Status

Completed107
unknown25
Terminated19
Recruiting11
Active, not recruiting5
Withdrawn5

Development Timeline

Analytics

Development Status

Total Trials
178
Active
16
Success Rate
84.9%
Most Advanced
Phase 4

Trials by Phase

Early Phase 17 (4.0%)
Phase 132 (18.1%)
Phase 259 (33.3%)
Phase 328 (15.8%)
Phase 421 (11.9%)
N/A30 (16.9%)

Trials by Status

completed10760%
suspended11%
not_yet_recruiting42%
terminated1911%
active_not_recruiting53%
withdrawn53%
recruiting116%
unknown2514%
enrolling_by_invitation11%

Recent Activity

Clinical Trials (178)

Showing 20 of 178 trialsScroll for more
NCT07737262Phase 3

Prophylactic NAC to Improve Platelet Engraftment After Haploidentical Transplantation in Severe Aplastic Anemia Patients

Not Yet Recruiting
NCT02719392Phase 4

A Pilot Study Investigating the Efficacy of Minocycline and N-Acetyl Cysteine for Bipolar Depression

Withdrawn
NCT06236165Phase 2

Clinical Study Evaluating Efficacy, Safety and Molecular Mechanism of N-acetylcysteine Supplementation in Patients With Hepatic and Post Hepatic Jaundice

Completed
NCT04520139Phase 1

Effect of NAC on Preventing Chemo-Related Cognitive Impairments in Ovarian Ca Pts Treated W/ PBT

Recruiting
NCT05537220Phase 3

Oral N-acetylcysteine for Retinitis Pigmentosa

Active Not Recruiting
NCT05604586Not Applicable

Assessment of the Impact of N-acetylcysteine Supplementation on Physical Performance

Completed
NCT02750319Phase 3

Amiodarone and N-Acetylcysteine or Amiodarone Alone for Preventing Atrial Fibrillation After Thoracic Surgery

Active Not Recruiting
NCT05494398Phase 2

Targeting the Neurobiology of RRB in Autism Using N-acetylcysteine: Open Label

Enrolling By Invitation
NCT04278898Phase 2

Targeting the Neurobiology of RRB in Autism Using N-acetylcysteine: Single-dose

Recruiting
NCT05610072Early Phase 1

Behavioral Effects of Drugs (Inpatient): 43 (Opioids, Cocaine, n-Acetylcysteine)

Completed
NCT04374461Phase 2

A Study of N-acetylcysteine in Patients With COVID-19 Infection

Active Not Recruiting
NCT03652753Phase 4

Pilon Fracture With Intra-articular Injection of N-Acetylcysteine (Pilon NAC)

Recruiting
NCT00775476Phase 2

Treatment of Systemic Lupus Erythematosus (SLE) With N-acetylcysteine

Active Not Recruiting
NCT07543458Phase 3

Therapeutics for Moderate and Severe Dengue

Not Yet Recruiting
NCT05142735Not Applicable

Effects of NAC on Symptoms of CHR Patients

Recruiting
NCT07464886Phase 3

Prefrontal Glutamatergic Modulation by NAC and MBCT for Depression in Youth

Recruiting
NCT05123365Phase 1

An Optimal Dose Finding Study of N-Acetylcysteine in Patients With Myeloproliferative Neoplasms

Recruiting
NCT06260566Phase 1

Tolerability of Enteral NAC in Infants

Not Yet Recruiting
NCT02583672Phase 2

Role of Oxidative Stress and Inflammation in Type 1 Gaucher Disease (GD1)

Completed
NCT05241262Phase 1

Study of N-acetylcysteine in the Treatment of Patients With the m.3243A>G Mutation and Low Brain Glutathione Levels

Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
178