Success Metrics

Clinical Success Rate
80.0%

Based on 4 completed trials

Completion Rate
80%(4/5)
Active Trials
7(58%)
Results Posted
100%(4 trials)
Terminated
1(8%)

Phase Distribution

Ph phase_1
5
42%
Ph phase_2
7
58%

Phase Distribution

5

Early Stage

7

Mid Stage

0

Late Stage

Phase Distribution12 total trials
Phase 1Safety & dosage
5(41.7%)
Phase 2Efficacy & side effects
7(58.3%)

Highest Phase Reached

Phase 2

Trial Status & Enrollment

Completion Rate

80.0%

4 of 5 finished

Non-Completion Rate

20.0%

1 ended early

Currently Active

7

trials recruiting

Total Trials

12

all time

Status Distribution
Active(7)
Completed(4)
Terminated(1)

Detailed Status

Recruiting6
Completed4
Terminated1
Active, not recruiting1

Development Timeline

Analytics

Development Status

Total Trials
12
Active
7
Success Rate
80.0%
Most Advanced
Phase 2

Trials by Phase

Phase 15 (41.7%)
Phase 27 (58.3%)

Trials by Status

terminated18%
active_not_recruiting18%
recruiting650%
completed433%

Recent Activity

Clinical Trials (12)

Showing 12 of 12 trials
NCT07104331Phase 2

SARC046: A Phase II Trial of Nab-Sirolimus in Patients With Progressing or Symptomatic Epithelioid Hemangioendothelioma

Recruiting
NCT06308419Phase 1

A Phase I Trial of Combination Gemcitabine and Nab-Sirolimus in Advanced Leiomyosarcomas or Advanced Soft-Tissue Sarcomas With TSC2 or TSC1 Loss-of-function Mutations or Deletions

Recruiting
NCT06494150Phase 2

Nab-Sirolimus and Endocrine Therapy in Recurrent Low Grade Serous Ovarian Cancer (NARETO)

Recruiting
NCT05997017Phase 2

Trial of Nab-Sirolimus in Combination With Letrozole in Patients With Advanced or Recurrent Endometrioid Endometrial Cancer

Recruiting
NCT05661461Phase 1

Dose-escalation Study to Assess Safety and Pharmacokinetics of Nab-Sirolimus in Patients With Locally Advanced or Metastatic Solid Tumors and Moderate Liver Impairment

Recruiting
NCT05840510Phase 1

Adagrasib in Combination With Nab-Sirolimus in Patients With Advanced Solid Tumors and Non-Small Cell Lung Cancer With a KRAS G12C Mutation (KRYSTAL -19)

Terminated
NCT02587325Phase 1

Phase 1/1b Study With Nab-sirolimus for Patients With Severe Pulmonary Arterial Hypertension

Completed
NCT05997056Phase 2

Trial of Nab-sirolimus in Patients With Well-differentiated Neuroendocrine Tumors (NETs) of the Gastrointestinal Tract, Lung, or Pancreas Who Have Not Received Prior Treatment With mTOR Inhibitors

Recruiting
NCT05103358Phase 2

Phase 2 Basket Trial of Nab-sirolimus in Patients With Malignant Solid Tumors With Pathogenic Alterations in TSC1/TSC2 Genes (PRECISION 1)

Active Not Recruiting
NCT03439462Phase 1

Nab-Sirolimus in Combination With FOLFOX & BEV as 1st Line Therapy in Patients With Advanced or Metastatic Colorectal Cancer

Completed
NCT03463265Phase 2

Nab-sirolimus in Recurrent High Grade Glioma and Newly Diagnosed Glioblastoma

Completed
NCT02494570Phase 2

A Phase 2 Study of Nab-sirolimus (ABI-009) in Patients With Advanced Malignant PEComa

Completed

All 12 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
12