Success Metrics

Clinical Success Rate
50.0%

Based on 7 completed trials

Completion Rate
50%(7/14)
Active Trials
12(34%)
Results Posted
171%(12 trials)
Terminated
7(20%)

Phase Distribution

Ph phase_3
1
3%
Ph phase_1
18
51%
Ph phase_2
16
46%

Phase Distribution

18

Early Stage

16

Mid Stage

1

Late Stage

Phase Distribution35 total trials
Phase 1Safety & dosage
18(51.4%)
Phase 2Efficacy & side effects
16(45.7%)
Phase 3Large-scale testing
1(2.9%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

35.0%

7 of 20 finished

Non-Completion Rate

65.0%

13 ended early

Currently Active

12

trials recruiting

Total Trials

35

all time

Status Distribution
Active(14)
Completed(7)
Terminated(13)
Other(1)

Detailed Status

Recruiting8
Completed7
Terminated7
Withdrawn6
Active, not recruiting4
Enrolling by invitation1

Development Timeline

Analytics

Development Status

Total Trials
35
Active
12
Success Rate
50.0%
Most Advanced
Phase 3

Trials by Phase

Phase 118 (51.4%)
Phase 216 (45.7%)
Phase 31 (2.9%)

Trials by Status

completed720%
enrolling_by_invitation13%
recruiting823%
active_not_recruiting411%
suspended13%
not_yet_recruiting13%
withdrawn617%
terminated720%

Recent Activity

Clinical Trials (35)

Showing 20 of 35 trialsScroll for more
NCT05642195Phase 1

Evaluation of a Cancer Lysate Vaccine and Montanide (Registered Trademark) ISA-51 VG With or Without the IL-15 Super-Agonist N-803 as Adjuvant Therapy for PD-L1 Negative Non-Small Cell Lung Cancer

Suspended
NCT06765902Phase 2

Immunotherapy Before and After Surgery

Withdrawn
NCT06745908Phase 3

Clinical Trial of N-803 Plus Tislelizumab or Prior Failed Immune Checkpoint Inhibitor and Docetaxel Versus Docetaxel Monotherapy in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Acquired Resistance to Immune Checkpoint In

Recruiting
NCT06149481Phase 1

Phase I/II Study of the Combination Immunotherapy Regimen: SX-682, TriAdeno Vaccine, Retifanlimab and IL-15 Agonist N-803 (STAR15) for Metastatic Colorectal Cancer (mCRC)

Recruiting
NCT06253494Phase 1

Pembrolizumab, Lenvatinib and IL-15 Superagonist N-803 in Combination With HER2 Targeting Autologous Dendritic Cell (AdHER2DC) Vaccine in Participants With Advanced or Metastatic Endometrial Cancer

Recruiting
NCT06161545Phase 2

Pembrolizumab + N-803 Alone or in Combination With PD-L1 t-haNK Cells for Resectable Head and Neck Squamous Cell Carcinoma

Recruiting
NCT04847466Phase 2

Immunotherapy Combination: Irradiated PD-L1 CAR-NK Cells Plus Pembrolizumab Plus N-803 for Subjects With Recurrent/Metastatic Gastric or Head and Neck Cancer

Active Not Recruiting
NCT05618925Phase 1

Study for Subjects With Relapsed/Refractory Non- Hodgkin Lymphoma

Recruiting
NCT07049432Phase 1

N-803 Maintenance Therapy Post CAR T-cell Therapy in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphomas

Withdrawn
NCT05245292Phase 1

3BNC117-LS and 10-1074-LS Plus N-803 (bNAb+N-803)

Completed
NCT07477366Phase 2

Study of CD19 t-haNK and NAI With Rituximab in Participants With Indolent Non-Hodgkin Lymphoma

Not Yet Recruiting
NCT07085338Phase 2

A Phase II Study With a Safety Run-In of the Addition of N-803 to a Chemoimmunotherapy Backbone for the Treatment of Patients With Relapsed or Refractory Neuroblastoma

Recruiting
NCT06061809Phase 2

N-803 and PD-L1 t-haNK Combined With Bevacizumab for Recurrent or Progressive Glioblastoma

Recruiting
NCT07145164Phase 2

Interleukin-15 to Promote Post-ART Control of HIV

Enrolling By Invitation
NCT04390399Phase 2

Combination Immunotherapy Plus Standard-of-Care Chemotherapy Versus Standard-of-Care Chemotherapy for the Treatment of Locally Advanced or Metastatic Pancreatic Cancer

Active Not Recruiting
NCT06710288Phase 2

A Phase 2, Open-label, Single-arm Study Of Autologous M-CENK Adoptive Cell Therapy And N-803 (IL-15 Superagonist) In Combination With Gemcitabine In Participants With Recurrent Platinum-Resistant High-Grade Ovarian Cancer

Recruiting
NCT03022825Phase 2

QUILT-3.032: A Multicenter Clinical Trial of Intravesical Bacillus Calmette-Guerin (BCG) in Combination With ALT-803 (N-803) in Patients With BCG Unresponsive High Grade Non-Muscle Invasive Bladder Cancer

Active Not Recruiting
NCT06040918Phase 1

Single Center Study Of N-803 Stimulation On Expansion, Enrichment, Proliferation Of Natural Killer Cells Collected By Apheresis

Completed
NCT03493945Phase 1

Phase I/II Study of Immunotherapy Combination BN-Brachyury Vaccine, M7824, N-803 and Epacadostat (QuEST1)

Completed
NCT04247282Phase 1

Anti-PD-L1/TGF-beta Trap (M7824) Alone and in Combination With TriAd Vaccine and N-803 for Resectable Head and Neck Squamous Cell Carcinoma Not Associated With Human Papillomavirus Infection

Completed

Drug Details

Intervention Type
DRUG
Total Trials
35