Success Metrics

Clinical Success Rate
84.5%

Based on 49 completed trials

Completion Rate
84%(49/58)
Active Trials
14(15%)
Results Posted
57%(28 trials)
Terminated
9(9%)

Phase Distribution

Ph phase_2
28
29%
Ph phase_3
17
18%
Ph phase_4
14
15%
Ph early_phase_1
5
5%
Ph not_applicable
3
3%
Ph phase_1
27
28%

Phase Distribution

32

Early Stage

28

Mid Stage

31

Late Stage

Phase Distribution94 total trials
Early Phase 1First-in-human
5(5.3%)
Phase 1Safety & dosage
27(28.7%)
Phase 2Efficacy & side effects
28(29.8%)
Phase 3Large-scale testing
17(18.1%)
Phase 4Post-market surveillance
14(14.9%)
N/ANon-phased studies
3(3.2%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

76.6%

49 of 64 finished

Non-Completion Rate

23.4%

15 ended early

Currently Active

14

trials recruiting

Total Trials

95

all time

Status Distribution
Active(17)
Completed(49)
Terminated(15)
Other(14)

Detailed Status

Completed49
unknown13
Terminated9
Recruiting8
Withdrawn6
Active, not recruiting6

Development Timeline

Analytics

Development Status

Total Trials
95
Active
14
Success Rate
84.5%
Most Advanced
Phase 4

Trials by Phase

Early Phase 15 (5.3%)
Phase 127 (28.7%)
Phase 228 (29.8%)
Phase 317 (18.1%)
Phase 414 (14.9%)
N/A3 (3.2%)

Trials by Status

completed4952%
unknown1314%
not_yet_recruiting33%
terminated99%
withdrawn66%
suspended11%
active_not_recruiting66%
recruiting88%

Recent Activity

Clinical Trials (95)

Showing 20 of 95 trialsScroll for more
NCT06638671Phase 4

Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity

Active Not Recruiting
NCT01905046Phase 3

Metformin Hydrochloride in Preventing Breast Cancer in Patients With Atypical Hyperplasia or In Situ Breast Cancer

Active Not Recruiting
NCT02874430Phase 2

Metformin Hydrochloride and Doxycycline in Treating Patients With Localized Breast or Uterine Cancer

Terminated
NCT04545736Phase 1

Oral Metformin for Treatment of ABCA4 Retinopathy

Recruiting
NCT04530383Phase 2

Metformin for People With CFRD on CFTR Modulator Therapy to Improve Ion Channel Function

Recruiting
NCT07368569Phase 1

A Study in Healthy People to Test Whether BI 764198 Influences the Amount of Metformin in the Body

Completed
NCT02581137Phase 2

Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion

Active Not Recruiting
NCT05445791Phase 3

Metformin Plus Tyrosine Kinase Inhibitors for Treatment of Patients With Non-small Cell Lung Cancer With EGFR Mutations

Recruiting
NCT06899061Phase 1

Modular Clinical Pharmacology Study to Evaluate the Drug-drug Interaction Potential and Relative Bioavailability of Saruparib

Active Not Recruiting
NCT02122185Phase 2

Metformin and Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Completed
NCT06611501Phase 2

Glycemic Regulation as Endometriosis Adjunct Treatment

Recruiting
NCT03514108Phase 4

DANHEART (H-HeFT and Met-HeFT)

Completed
NCT07387900Phase 2

Evaluation of the Chemo-preventive Effect of Combined Topical and Systemic Metformin on Oral Leukoplakia

Recruiting
NCT02336087Phase 1

Gemcitabine Hydrochloride, Paclitaxel Albumin-Stabilized Nanoparticle Formulation, Metformin Hydrochloride, and a Standardized Dietary Supplement in Treating Patients With Pancreatic Cancer That Cannot be Removed by Surgery

Active Not Recruiting
NCT07380841Not Applicable

Metformin vs Inositol vs Diet vs Combination Therapy in PCOS

Completed
NCT03076281Phase 2

Metformin Hydrochloride and Doxycycline in Treating Patients With Head and Neck Squamous Cell Carcinoma

Terminated
NCT06504862Phase 1

A Study in Healthy Men to Test Whether Zongertinib Influences the Amount of 4 Other Medicines (Dabigatran, Rosuvastatin, Metformin, and Furosemide) in the Blood

Completed
NCT04221750Phase 3

Diet and Exercise Plus Metformin to Treat Frailty in Obese Seniors

Completed
NCT03109847Phase 2

Metformin to Mitigate Sequelae of Radioactive Iodine Treatment for Thyroid Cancers

Terminated
NCT06707012Phase 4

Efficacy of Metformin as an Adjunct to Standard Antidepressant Therapy in Treating Depression Among Obese Patients

Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
95