Success Metrics

Clinical Success Rate

80.4%

Based on 111 completed trials

Completion Rate

80%(111/138)

Active Trials

25(10%)

Results Posted

36%(40 trials)

Terminated

27(11%)

Phase Distribution

Ph phase_1

11%

Ph phase_4

10%

Ph phase_2

29%

Ph early_phase_1

Ph not_applicable

31%

Ph phase_3

13%

Phase Distribution

Early Stage

Mid Stage

Late Stage

Phase Distribution241 total trials

Early Phase 1First-in-human

12(5.0%)

Phase 1Safety & dosage

26(10.8%)

Phase 2Efficacy & side effects

71(29.5%)

Phase 3Large-scale testing

32(13.3%)

Phase 4Post-market surveillance

24(10.0%)

N/ANon-phased studies

76(31.5%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

72.5%

111 of 153 finished

Non-Completion Rate

27.5%

42 ended early

Currently Active

trials recruiting

Total Trials

243

all time

Status Distribution

Active(40)

Completed(111)

Terminated(42)

Other(50)

Detailed Status

Completed111

unknown49

Terminated27

Recruiting19

Withdrawn15

Not yet recruiting14

Development Timeline

Analytics

Development Status

Total Trials

243

Active

Success Rate

80.4%

Most Advanced

Phase 4

Trials by Phase

Early Phase 112 (5.0%)

Phase 126 (10.8%)

Phase 271 (29.5%)

Phase 332 (13.3%)

Phase 424 (10.0%)

N/A76 (31.5%)

Trials by Status

recruiting198%

withdrawn156%

unknown4920%

completed11146%

enrolling_by_invitation10%

terminated2711%

not_yet_recruiting146%

suspended10%

active_not_recruiting62%

Recent Activity

25 active trials

Showing 5 of 243

completedphase_2

Effects of Hydrocortisone, Melatonin, and Placebo on Jet Lag

NCT00097474

not_yet_recruitingphase_3

The Effect of Adjunctive Melatonin With Colistin in Patients With Multidrug-Resistant Gram-Negative Bacterial Infections

NCT07503600

recruitingphase_2

Melatonin for Treatment of Delirium in Critically Ill Adult Patients

NCT05713877

not_yet_recruitingphase_2

Melatonin Versus Placebo for Bipolar Disorder

NCT07472075

completedphase_4

The Effect of Dexmedetomidine Infusion Alone Versus the Combination of Dexmedetomidine and Melatonin on Reduction of Post-operative Delirium (POD) After Open Brain Surgeries

NCT07475156

View all 243 trials

Clinical Trials (243)

Showing 20 of 243 trialsScroll for more

NCT00097474Phase 2

Effects of Hydrocortisone, Melatonin, and Placebo on Jet Lag

Completed

NCT07503600Phase 3

The Effect of Adjunctive Melatonin With Colistin in Patients With Multidrug-Resistant Gram-Negative Bacterial Infections

Not Yet Recruiting

NCT05713877Phase 2

Melatonin for Treatment of Delirium in Critically Ill Adult Patients

Recruiting

NCT07472075Phase 2

Melatonin Versus Placebo for Bipolar Disorder

Not Yet Recruiting

NCT07475156Phase 4

The Effect of Dexmedetomidine Infusion Alone Versus the Combination of Dexmedetomidine and Melatonin on Reduction of Post-operative Delirium (POD) After Open Brain Surgeries

Completed

NCT03540485Phase 1

Safety and Efficacy of Melatonin in Patients With Multiple Progressive Primary Sclerosis

Terminated

NCT07336277Phase 3

Sleep Quality and the Efficacy of a Multimodal Sleep Pathway in Hospitalized Orthopedic Trauma Patients

Not Yet Recruiting

NCT02642640Not Applicable

Interaction of Melatonin and MTNR1B Genotype on Glucose Control - Study 1

Completed

NCT04588233Not Applicable

Melatonin Adolescent Research Study

Recruiting

NCT07375342Not Applicable

Melatonin for Post Tonsillectomy Emergence Agitation in Pediatric

Enrolling By Invitation

NCT07369284Phase 2

Melatonin for Glycemic Control in Gestational Diabetes Mellitus

Not Yet Recruiting

NCT06404086Phase 2

RECOVER-SLEEP: Platform Protocol

Completed

NCT06404112Phase 2

RECOVER-SLEEP: Platform Protocol, Appendix_B (CPSD)

Active Not Recruiting

NCT07305350Phase 2

EFFICACY OF MELATONIN IN MANAGEMENT OF HYPOXIC ISCHEMIC ENCEPHALOPATHY (HIE) IN NEONATES

Active Not Recruiting

NCT05084196Phase 3

Melatonin for Prevention of Kidney Injury

Recruiting

NCT06012175Not Applicable

Melatonin for Knee Osteoarthritis Patients

Completed

NCT05474846Phase 2

Combination Therapy for Treatment of Sleep Disturbance in Patients With Advanced Cancer

Recruiting

NCT07221968Phase 2

Melatonin for the Treatment of DEE-SWAS

Not Yet Recruiting

NCT06226025Phase 2

Correcting Circadian Rhythms to Breakthrough in Bipolar Disorder

Recruiting

NCT00262470Phase 1

Treatment of Orthostatic Intolerance

Active Not Recruiting

Drug Details

Intervention Type: DRUG
Total Trials: 243