Success Metrics

Clinical Success Rate
93.1%

Based on 27 completed trials

Completion Rate
93%(27/29)
Active Trials
5(14%)
Results Posted
67%(18 trials)
Terminated
2(6%)

Phase Distribution

Ph phase_1
22
63%
Ph phase_3
5
14%
Ph phase_2
8
23%

Phase Distribution

22

Early Stage

8

Mid Stage

5

Late Stage

Phase Distribution35 total trials
Phase 1Safety & dosage
22(62.9%)
Phase 2Efficacy & side effects
8(22.9%)
Phase 3Large-scale testing
5(14.3%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

90.0%

27 of 30 finished

Non-Completion Rate

10.0%

3 ended early

Currently Active

5

trials recruiting

Total Trials

35

all time

Status Distribution
Active(5)
Completed(27)
Terminated(3)

Detailed Status

Completed27
Active, not recruiting5
Terminated2
Withdrawn1

Development Timeline

Analytics

Development Status

Total Trials
35
Active
5
Success Rate
93.1%
Most Advanced
Phase 3

Trials by Phase

Phase 122 (62.9%)
Phase 28 (22.9%)
Phase 35 (14.3%)

Trials by Status

withdrawn13%
completed2777%
terminated26%
active_not_recruiting514%

Recent Activity

Clinical Trials (35)

Showing 20 of 35 trialsScroll for more
NCT02734004Phase 1

A Phase I/II Study of MEDI4736 in Combination With Olaparib in Patients With Advanced Solid Tumors.

Active Not Recruiting
NCT02617277Phase 1

Safety, Tolerability and Pharmacokinetics of AZD1775 (Adavosertib) Plus MEDI4736 (Durvalumab) in Patients With Advanced Solid Tumours

Completed
NCT02499328Phase 1

Study to Assess MEDI4736 With Either AZD9150 or AZD5069 in Advanced Solid Tumors & Relapsed Metastatic Squamous Cell Carcinoma of Head & Neck

Completed
NCT02546661Phase 1

Open-Label, Randomised, Multi-Drug, Biomarker-Directed, Phase 1b Study in Pts w/ Muscle Invasive Bladder Cancer

Active Not Recruiting
NCT02639026Phase 1

Trial Of Hypofractionated Radiotherapy In Combination With MEDI4736 And Tremelimumab For Patients With Metastatic Melanoma And Lung, Breast And Pancreatic Cancers

Completed
NCT02273375Phase 3

Double Blind Placebo Controlled Controlled Study of Adjuvant MEDI4736 In Completely Resected NSCLC

Active Not Recruiting
NCT02087423Phase 2

A Global Study to Assess the Effects of MEDI4736 (Durvalumab) in Patients With Locally Advanced or Metastatic Non Small Cell Lung Cancer

Completed
NCT02299999Phase 2

SAFIR02_Breast - Efficacy of Genome Analysis as a Therapeutic Decision Tool for Patients With Metastatic Breast Cancer

Active Not Recruiting
NCT03616886Phase 1

Paclitaxel + Carboplatin + Durvalumab With or Without Oleclumab for Previously Untreated Locally Recurrent Inoperable or Metastatic TNBC

Active Not Recruiting
NCT02819596Phase 2

MEDI4736 Combinations in Metastatic Renal Cell Carcinoma

Completed
NCT02454933Phase 3

Study of AZD9291 Plus MEDI4736 Versus AZD9291 Monotherapy in NSCLC After Previous EGFR TKI Therapy in T790M Mutation Positive Tumours

Completed
NCT02125461Phase 3

A Global Study to Assess the Effects of MEDI4736 Following Concurrent Chemoradiation in Patients With Stage III Unresectable Non-Small Cell Lung Cancer

Completed
NCT02291055Phase 1

A Study of ADXS11-001 or MEDI4736 Alone or Combination In Cervical or Human Papillomavirus (HPV)+ Head & Neck Cancer

Terminated
NCT02489448Phase 1

Neoadjuvant MEDI4736 Concomitant With Weekly Nab-paclitaxel and Dose-dense AC for Stage I-III Triple Negative Breast Cancer

Completed
NCT02592551Phase 2

MEDI4736 Or MEDI4736 + Tremelimumab In Surgically Resectable Malignant Pleural Mesothelioma

Completed
NCT02088112Phase 1

MEDI4736 (Anti PD-L1) Combined With Gefitinib in Subjects With Non-Small Cell Lung Cancer(NSCLC).

Completed
NCT02318277Phase 1

A Study of Epacadostat (INCB024360) in Combination With Durvalumab (MEDI4736) in Subjects With Selected Advanced Solid Tumors (ECHO-203)

Completed
NCT02551159Phase 3

Phase III Open Label Study of MEDI 4736 With/Without Tremelimumab Versus Standard of Care (SOC) in Recurrent/Metastatic Head and Neck Cancer

Completed
NCT02227667Phase 2

Evaluate the Efficacy of MEDI4736 in Immunological Subsets of Advanced Colorectal Cancer

Completed
NCT01693562Phase 1

A Phase 1/2 Study to Evaluate MEDI4736

Completed

Drug Details

Intervention Type
DRUG
Total Trials
35