Success Metrics

Clinical Success Rate
84.2%

Based on 16 completed trials

Completion Rate
84%(16/19)
Active Trials
23(43%)
Results Posted
69%(11 trials)
Terminated
3(6%)

Phase Distribution

Ph phase_4
3
6%
Ph phase_1
2
4%
Ph phase_2
24
45%
Ph phase_3
8
15%
Ph not_applicable
3
6%

Phase Distribution

2

Early Stage

24

Mid Stage

11

Late Stage

Phase Distribution40 total trials
Phase 1Safety & dosage
2(5.0%)
Phase 2Efficacy & side effects
24(60.0%)
Phase 3Large-scale testing
8(20.0%)
Phase 4Post-market surveillance
3(7.5%)
N/ANon-phased studies
3(7.5%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

76.2%

16 of 21 finished

Non-Completion Rate

23.8%

5 ended early

Currently Active

23

trials recruiting

Total Trials

53

all time

Status Distribution
Active(29)
Completed(16)
Terminated(5)
Other(3)

Detailed Status

Completed16
Recruiting12
Active, not recruiting11
Not yet recruiting6
Terminated3
unknown2

Development Timeline

Analytics

Development Status

Total Trials
53
Active
23
Success Rate
84.2%
Most Advanced
Phase 4

Trials by Phase

Phase 12 (5.0%)
Phase 224 (60.0%)
Phase 38 (20.0%)
Phase 43 (7.5%)
N/A3 (7.5%)

Trials by Status

recruiting1223%
completed1630%
not_yet_recruiting611%
unknown24%
suspended12%
terminated36%
withdrawn24%
active_not_recruiting1121%

Recent Activity

Clinical Trials (53)

Showing 20 of 53 trialsScroll for more
NCT05564390Phase 2

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

Recruiting
NCT07725497Phase 2

A Study of Luspatercept in People With Anemia

Recruiting
NCT04539236Phase 1

Luspatercept and Lenalidomide (L2) in Lower-risk, Non-del(5q) MDS Patients

Suspended
NCT07681440

A Study to Evaluate Luspatercept Utilization in Patients With Lower Risk Myelodysplastic Syndromes or Beta-thalassemia

Terminated
NCT04064060Phase 3

A Study to Evaluate Long-term Safety in Participants Who Have Participated in Other Luspatercept (ACE-536) Clinical Trials

Recruiting
NCT05949684Phase 3

ELEMENT-MDS: A Study to Compare the Efficacy and Safety of Luspatercept in Participants With Myelodysplastic Syndrome (MDS) and Anemia Not Receiving Blood Transfusions

Active Not Recruiting
NCT05664737Phase 2

A Study to Determine the Efficacy and Safety of Luspatercept in Adult Participants and to Evaluate the Safety and Pharmacokinetics in and Adolescent Participants With Alpha (α)-Thalassemia

Recruiting
NCT06113302Phase 2

A Pilot, Open-Label Study of Luspatercept for Patients With Lower Risk Myelodysplastic Syndromes (MDS)

Active Not Recruiting
NCT06045689Phase 3

A Study to Assess Luspatercept in Lower-risk Myelodysplastic Syndrome Participants

Active Not Recruiting
NCT07636486Phase 2

Luspatercept vs Epoetin in Treating Poor Erythroid Engraftment for Hematological Malignancies

Not Yet Recruiting
NCT06424639Phase 4

Luspatercept Plus CsA vs CsA for the Treatment of Newly Diagnosed Non-Transfusion-Dependent NSAA

Withdrawn
NCT07215975

A Real-World Study to Evaluate Luspatercept in Adults With Transfusion-Dependent Beta-Thalassemia in the Middle East

Recruiting
NCT07073690

Treatment Patterns and Outcomes in Patients With Lower-risk Myelodysplastic Syndromes Treated With Luspatercept in China

Completed
NCT07463820Phase 2

A Trial Comparing Three Different Treatment Options for Adults With Low-Risk Myelodysplasia and Anemia (A MyeloMATCH Treatment Trial)

Not Yet Recruiting
NCT05732961Phase 2

Luspatercept for Anemia in Lower Risk MDS or Non-proliferative MDS/MPN Neoplasms

Active Not Recruiting
NCT04477850Phase 2

A Study to Evaluate the Efficacy, Drug Levels and Safety of Luspatercept (ACE-536) for the Treatment of Anemia Due to IPSS-R Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes in Chinese and Japanese Participants With Ring Sideroblasts Who Require Red Blood Cell Transfusions

Completed
NCT07539779Phase 2

Luspatercept in Preventing Poor Erythroid Engraftment for Hematological Malignancies With Moderate to Severe Myelofibrosis

Not Yet Recruiting
NCT06517875Phase 2

Study of Momelotinib in Combination With Luspatercept in Participants With Transfusion Dependent Myelofibrosis

Recruiting
NCT06788691Phase 2

Luspatercept for Clonal Cytopenias of Uncertain Significance

Recruiting
NCT07096297Phase 2

Luspatercept + Darbepoetin in MDS

Recruiting

Drug Details

Intervention Type
BIOLOGICAL
Total Trials
53