Success Metrics

Clinical Success Rate
83.3%

Based on 10 completed trials

Completion Rate
83%(10/12)
Active Trials
2(12%)
Results Posted
50%(5 trials)
Terminated
2(12%)

Phase Distribution

Ph early_phase_1
2
12%
Ph not_applicable
6
35%
Ph phase_4
3
18%
Ph phase_1
6
35%

Phase Distribution

8

Early Stage

0

Mid Stage

3

Late Stage

Phase Distribution17 total trials
Early Phase 1First-in-human
2(11.8%)
Phase 1Safety & dosage
6(35.3%)
Phase 4Post-market surveillance
3(17.6%)
N/ANon-phased studies
6(35.3%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

76.9%

10 of 13 finished

Non-Completion Rate

23.1%

3 ended early

Currently Active

2

trials recruiting

Total Trials

17

all time

Status Distribution
Active(3)
Completed(10)
Terminated(3)
Other(1)

Detailed Status

Completed10
Recruiting2
Terminated2
unknown1
Withdrawn1
Not yet recruiting1

Development Timeline

Analytics

Development Status

Total Trials
17
Active
2
Success Rate
83.3%
Most Advanced
Phase 4

Trials by Phase

Early Phase 12 (11.8%)
Phase 16 (35.3%)
Phase 43 (17.6%)
N/A6 (35.3%)

Trials by Status

recruiting212%
unknown16%
terminated212%
withdrawn16%
completed1059%
not_yet_recruiting16%

Recent Activity

Clinical Trials (17)

Showing 17 of 17 trials
NCT07799298Not Applicable

Spleen Preservation Versus Splenectomy in Left Pancreatectomy for Pancreatic Ductal Adenocarcinoma (SPLENDID)

Not Yet Recruiting
NCT04751331Phase 1

Neural Response to Inflammatory Challenge in Major Depressive Disorder

Recruiting
NCT06624436Phase 4

Immunomodulatory Effects of Dexamethasone, Tocilizumab and Anakinra During Experimental Human Endotoxemia

Recruiting
NCT03953196Early Phase 1

A Study Exploring the Use of Vaccine and Antigen Challenges for Immune Monitoring in Healthy Participants

Completed
NCT04057807Early Phase 1

Peripheral Benzodiazepine Receptors (PBR28) Brain PET Imaging With Lipopolysaccharide Challenge for the Study of Microglia Function in Alzheimer's Disease

Completed
NCT03271814Phase 1

Brain Biomarker on Inflammation Response

Withdrawn
NCT05570643Not Applicable

The Effects of Human Endotoxemia on Functional Capacity of Hematopoietic Stem and Progenitor Cells

Completed
NCT03426995Phase 1

First-time-in-Human (FTIH) Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single (in Both Fed and Fasted States) or Repeat Doses of GSK3358699

Terminated
NCT02875028Phase 4

Vorapaxar in the Human Endotoxemia Model

Completed
NCT01587807Phase 1

A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Doses of Inhaled GSK1995057

Completed
NCT02642237Not Applicable

The Effects of Preceding LPS Administration on the Fluenz-induced Immune Response

Completed
NCT01965600Phase 1

A Study To Evaluate The Safety And Effects On The Body Of An Investigational Drug Using An Endotoxin-Induced Inflammatory Response Model

Terminated
NCT02246543Not Applicable

Whey Protein Study - Identification of Sustainable Satiety

Completed
NCT02157155Not Applicable

A Study of Intracellular Signaling in Muscle and Fat Cells During Ketosis

Completed
NCT01091571Phase 4

The Effects of Oral Dipyridamole Treatment on the Innate Immune Response During Human Endotoxemia

Completed
NCT01081392Not Applicable

Inflammatory Markers in Sputum After LPS Inhalation

Unknown
NCT00284869Phase 1

Ethnic Differences in the Inflammatory Response in Systemic Inflammation

Completed

All 17 trials loaded

Drug Details

Intervention Type
PROCEDURE
Total Trials
17