Success Metrics

Clinical Success Rate
25.0%

Based on 1 completed trials

Completion Rate
25%(1/4)
Active Trials
13(59%)
Results Posted
400%(4 trials)
Terminated
3(14%)

Phase Distribution

Ph phase_3
1
5%
Ph phase_1
7
32%
Ph phase_2
13
59%

Phase Distribution

7

Early Stage

13

Mid Stage

1

Late Stage

Phase Distribution21 total trials
Phase 1Safety & dosage
7(33.3%)
Phase 2Efficacy & side effects
13(61.9%)
Phase 3Large-scale testing
1(4.8%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

14.3%

1 of 7 finished

Non-Completion Rate

85.7%

6 ended early

Currently Active

13

trials recruiting

Total Trials

22

all time

Status Distribution
Active(14)
Completed(1)
Terminated(6)
Other(1)

Detailed Status

Recruiting11
Terminated3
Withdrawn3
Active, not recruiting2
unknown1
Not yet recruiting1

Development Timeline

Analytics

Development Status

Total Trials
22
Active
13
Success Rate
25.0%
Most Advanced
Phase 3

Trials by Phase

Phase 17 (33.3%)
Phase 213 (61.9%)
Phase 31 (4.8%)

Trials by Status

terminated314%
unknown15%
not_yet_recruiting15%
recruiting1150%
withdrawn314%
active_not_recruiting29%
completed15%

Recent Activity

Clinical Trials (22)

Showing 20 of 22 trialsScroll for more
NCT07573436Phase 1

Loncastuximab Tesirine and Rituximab as First-line Therapy in Patients With Post-transplant Lymphoproliferative Disorder (PLUTO)

Not Yet Recruiting
NCT04384484Phase 3

Study to Evaluate Loncastuximab Tesirine With Rituximab Versus Immunochemotherapy in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Active Not Recruiting
NCT04998669Phase 2

Loncastuximab Tesirine in Combination With Rituximab in Patients With Relapsed or Refractory Follicular Lymphoma

Recruiting
NCT04970901Phase 1

A Study to Evaluate the Safety and Anti-cancer Activity of Loncastuximab Tesirine in Combination With Other Anti-cancer Agents in Participants With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (LOTIS-7)

Recruiting
NCT06919939Phase 2

Epcoritamab in Combination With Loncastuximab Tesirine in Relapsed/Refractory Large B-cell Lymphoma

Recruiting
NCT05991388Phase 2

A Global Study of Novel Agents in Paediatric and Adolescent Relapsed and Refractory B-cell Non-Hodgkin Lymphoma

Recruiting
NCT05053659Phase 1

Loncastuximab Tesirine and Venetoclax for Relapsed/ Refractory Non-Hodgkin Lymphoma

Active Not Recruiting
NCT05464719Phase 2

A Phase II Study of Loncastuximab Tesirine as Consolidation Strategy in Patients With LBCL in PR After CAR T-cell Therapy

Recruiting
NCT06788964Phase 2

Loncastuximab Tesirine and Rituximab as Bridging Therapy Before Standard-of-care CAR-T Therapy in Patients With Large B-cell Lymphoma (CORAL)

Recruiting
NCT05600686Phase 2

Loncastuximab Tesirine and Rituximab Followed by DA-EPOCH-R for Treating Patients With High-Risk Diffuse Large B-cell Lymphoma

Recruiting
NCT05453396Phase 2

Loncastuximab Tesirine for the Treatment of Relapsed or Refractory B-Cell Malignancies

Recruiting
NCT05672251Phase 2

Loncastuximab Tesirine and Mosunetuzumab for the Treatment of Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Recruiting
NCT05660395Phase 1

A Study to Evaluate the Pharmacokinetics and Safety of Loncastuximab Tesirine in Participants With Relapsed or Refractory Diffuse Large B-cell Lymphoma or High-grade B-cell Lymphoma With Hepatic Impairment (LOTIS-10)

Recruiting
NCT05190705Phase 2

Loncastuximab Tesirine in WM

Recruiting
NCT05144009Phase 2

A Study of Loncastuximab Tesirine and Rituximab (Lonca-R) in Previously Untreated Unfit/Frail Participants With Diffuse Large B-cell Lymphoma (DLBCL)

Terminated
NCT03684694Phase 1

Safety and Efficacy Study of Loncastuximab Tesirine + Ibrutinib in Diffuse Large B-Cell or Mantle Cell Lymphoma

Terminated
NCT05222438Phase 2

Trial of Loncastuximab Tesirine in High Risk Diffuse Large B-cell Lymphoma Post Transplant

Withdrawn
NCT04699461Phase 2

Study to Evaluate the Efficacy and Safety of Loncastuximab Tesirine Versus Idelalisib in Participants With Relapsed or Refractory Follicular Lymphoma

Terminated
NCT03589469Phase 2

Study to Evaluate the Efficacy and Safety of Loncastuximab Tesirine in Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Completed
NCT05228249Phase 1

Loncastuximab Tesirine in Combination With Chemotherapy Prior to Stem Cell Transplant for the Treatment of Recurrent or Refractory Diffuse Large B-Cell Lymphoma

Withdrawn

Drug Details

Intervention Type
DRUG
Total Trials
22