Success Metrics

Clinical Success Rate
90.9%

Based on 10 completed trials

Completion Rate
91%(10/11)
Active Trials
0(0%)
Results Posted
90%(9 trials)
Terminated
1(8%)

Phase Distribution

Ph phase_2
1
8%
Ph phase_1
5
38%
Ph phase_3
4
31%

Phase Distribution

5

Early Stage

1

Mid Stage

4

Late Stage

Phase Distribution10 total trials
Phase 1Safety & dosage
5(50.0%)
Phase 2Efficacy & side effects
1(10.0%)
Phase 3Large-scale testing
4(40.0%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

76.9%

10 of 13 finished

Non-Completion Rate

23.1%

3 ended early

Currently Active

0

trials recruiting

Total Trials

13

all time

Status Distribution
Completed(10)
Terminated(3)

Detailed Status

Completed10
Withdrawn2
Terminated1

Development Timeline

Analytics

Development Status

Total Trials
13
Active
0
Success Rate
90.9%
Most Advanced
Phase 3

Trials by Phase

Phase 15 (50.0%)
Phase 21 (10.0%)
Phase 34 (40.0%)

Trials by Status

withdrawn215%
terminated18%
completed1077%

Recent Activity

Clinical Trials (13)

Showing 13 of 13 trials
NCT02135705

LOWER: Lomitapide Observational Worldwide Evaluation Registry

Completed
NCT04681170Phase 3

Efficacy and Safety of Lomitapide in Paediatric Patients With Homozygous Familial Hypercholesterolaemia (HoFH)

Completed
NCT02399839

Global Lomitapide Pregnancy Exposure Registry

Terminated
NCT01915771Phase 1

Study to Determine the Intra-subject Variability of Pharmacokinetics of Lomitapide in Healthy Subjects

Completed
NCT02080455Phase 1

Evaluate the Effect of Atorvastatin on the Pharmacokinetics of Lomitapide in Healthy Subjects.

Completed
NCT02080468Phase 1

Evaluate the Effect of Ethinyl Estradiol/Norgestimate on the Pharmacokinetics of Lomitapide in Healthy Female Subjects

Completed
NCT01760187Phase 1

Phase I Study of the Safety, Tolerability, PK & PD of Lomitapide in Japanese and Caucasian Subjects With Elevated LDL-C

Completed
NCT02173158Phase 3

Efficacy and Safety of Lomitapide in Japanese Patients With HoFH on Concurrent Lipid-Lowering Therapy

Completed
NCT00943306Phase 3

Long Term, Follow-on Study of Lomitapide in Patients With Homozygous Familial Hypercholesterolemia

Completed
NCT02765841Phase 3

Evaluate the Efficacy and Safety of Lomitapide in Pediatric Patients With Homozygous Familial Hypercholesterolemia on Stable Lipid-lowering Therapy

Withdrawn
NCT02044419Phase 1

A Comparative Bioavailability Study of Lomitapide 20 mg Intact vs Sprinkled

Completed
NCT02399852

Effects of Lomitapide on Carotid and Aortic Atherosclerosis

Withdrawn
NCT01556906Phase 2

Safety, Tolerability and Efficacy of Microsomal Triglyceride Protein (MTP) Inhibitor

Completed

All 13 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
13