Success Metrics

Clinical Success Rate
68.4%

Based on 39 completed trials

Completion Rate
68%(39/57)
Active Trials
45(36%)
Results Posted
62%(24 trials)
Terminated
18(15%)

Phase Distribution

Ph early_phase_1
4
3%
Ph phase_3
5
4%
Ph phase_4
1
1%
Ph not_applicable
11
9%
Ph phase_1
70
56%
Ph phase_2
25
20%

Phase Distribution

74

Early Stage

25

Mid Stage

6

Late Stage

Phase Distribution116 total trials
Early Phase 1First-in-human
4(3.4%)
Phase 1Safety & dosage
70(60.3%)
Phase 2Efficacy & side effects
25(21.6%)
Phase 3Large-scale testing
5(4.3%)
Phase 4Post-market surveillance
1(0.9%)
N/ANon-phased studies
11(9.5%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

59.1%

39 of 66 finished

Non-Completion Rate

40.9%

27 ended early

Currently Active

45

trials recruiting

Total Trials

124

all time

Status Distribution
Active(49)
Completed(39)
Terminated(27)
Other(9)

Detailed Status

Completed39
Recruiting36
Terminated18
Active, not recruiting9
Withdrawn9
unknown5

Development Timeline

Analytics

Development Status

Total Trials
124
Active
45
Success Rate
68.4%
Most Advanced
Phase 4

Trials by Phase

Early Phase 14 (3.4%)
Phase 170 (60.3%)
Phase 225 (21.6%)
Phase 35 (4.3%)
Phase 41 (0.9%)
N/A11 (9.5%)

Trials by Status

terminated1815%
completed3931%
enrolling_by_invitation11%
recruiting3629%
not_yet_recruiting32%
active_not_recruiting97%
suspended43%
unknown54%
withdrawn97%

Recent Activity

Clinical Trials (124)

Showing 20 of 124 trialsScroll for more
NCT03577431Phase 1

Liver Transplantation With Tregs at MGH

Active Not Recruiting
NCT06172296Phase 3

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

Recruiting
NCT07544992Phase 1

Locoregional Administration of Genetically Engineered Cells (EGFR/IL13Rα2 Pool-CAR T Cells) for the Treatment of Recurrent or Progressive High-Grade Gliomas

Recruiting
NCT06784726Phase 2

Odronextamab for Relapsed and Refractory Large B-cell Lymphomas Before CAR-T

Recruiting
NCT07261657Early Phase 1

N-803 in Patients With Progressive Synovial Sarcoma and Myxoid/Round Cell Liposarcoma Previously Treated With Adoptive Cellular Therapy

Recruiting
NCT06724237Phase 3

Testing Whether High Dose Chemotherapy and Infusion of the Patients' Own Stem Cells Improves Survival in Patients With Peripheral T-cell Lymphoma Who Achieved a Complete Response at the End of the Initial Chemotherapy

Recruiting
NCT01087294Phase 1

Administration of Anti-CD19-chimeric-antigen-receptor-transduced T Cells From the Original Transplant Donor to Patients With Recurrent or Persistent B-cell Malignancies After Allogeneic Stem Cell Transplantation

Completed
NCT01161199

The Use of Leukapheresis to Support HIV Pathogenesis Studies

Recruiting
NCT03226704

Leukapheresis for CAR or Adoptive Cell Therapy Manufacturing

Enrolling By Invitation
NCT07316010Phase 2

Phase 2 Trial of Lisocabtagene Maraleucel for Minimal Residual Disease in Patients With Large B-cell Lymphoma

Recruiting
NCT06735690Early Phase 1

Allogeneic CMV-Specific CD19-CAR T Cells Plus CMV-MVA Triplex Vaccine After Matched Related Donor Hematopoietic Cell Transplant for the Treatment of Patients With High-Risk Acute Lymphoblastic Leukemia

Recruiting
NCT03068819Phase 1

Cytokine Induced Memory-like NK Cell Adoptive Therapy for Relapsed AML After Allogeneic Hematopoietic Cell Transplant

Completed
NCT05707273Phase 1

CD19-Car T Cell Therapy for the Treatment of Older Adults With Acute Lymphoblastic Leukemia in First Remission

Active Not Recruiting
NCT03623373Phase 2

Acalabrutinib With Bendamustine / Rituximab Followed by Cytarabine / Rituximab for Untreated Mantle Cell Lymphoma

Completed
NCT07219147Phase 1

177^Lu-PSMA-617 in Combination With Sipuleucel-T for the Treatment of Metastatic Castration-Resistant Prostate Cancer

Recruiting
NCT06968195Phase 1

Autologous CAR T Cells Targeting GPC3 (RPCAR01) for the Treatment of Advanced or Metastatic GPC3 Expressing Hepatocellular Carcinoma

Suspended
NCT03710421Phase 1

CS1-CAR T Therapy Following Chemotherapy in Treating Patients With Relapsed or Refractory CS1 Positive Multiple Myeloma

Recruiting
NCT06435351Early Phase 1

Personalized Dendritic Cell Vaccine Pilot for High Risk TNBC After Neoadjuvant Therapy

Recruiting
NCT06871410Phase 1

Genetically Engineered Cells (CD83 CAR T Cells) for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

Recruiting
NCT06483048Phase 1

MUC1-Activated T Cells for the Treatment of Relapsed and Resistant Ovarian Cancer

Recruiting

Drug Details

Intervention Type
PROCEDURE
Total Trials
124