Success Metrics

Clinical Success Rate
88.1%

Based on 104 completed trials

Completion Rate
88%(104/118)
Active Trials
130(37%)
Results Posted
69%(72 trials)
Terminated
14(4%)

Phase Distribution

Ph phase_3
47
13%
Ph early_phase_1
4
1%
Ph not_applicable
18
5%
Ph phase_1
74
21%
Ph phase_2
182
52%
Ph phase_4
5
1%

Phase Distribution

78

Early Stage

182

Mid Stage

52

Late Stage

Phase Distribution330 total trials
Early Phase 1First-in-human
4(1.2%)
Phase 1Safety & dosage
74(22.4%)
Phase 2Efficacy & side effects
182(55.2%)
Phase 3Large-scale testing
47(14.2%)
Phase 4Post-market surveillance
5(1.5%)
N/ANon-phased studies
18(5.5%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

75.9%

104 of 137 finished

Non-Completion Rate

24.1%

33 ended early

Currently Active

130

trials recruiting

Total Trials

349

all time

Status Distribution
Active(161)
Completed(104)
Terminated(33)
Other(51)

Detailed Status

Completed104
Recruiting79
Active, not recruiting51
unknown48
Not yet recruiting30
Withdrawn19

Development Timeline

Analytics

Development Status

Total Trials
349
Active
130
Success Rate
88.1%
Most Advanced
Phase 4

Trials by Phase

Early Phase 14 (1.2%)
Phase 174 (22.4%)
Phase 2182 (55.2%)
Phase 347 (14.2%)
Phase 45 (1.5%)
N/A18 (5.5%)

Trials by Status

unknown4814%
withdrawn195%
completed10430%
suspended31%
active_not_recruiting5115%
recruiting7923%
enrolling_by_invitation10%
not_yet_recruiting309%
terminated144%

Recent Activity

Clinical Trials (349)

Showing 20 of 349 trialsScroll for more
NCT07405164Phase 3

Extension Study for Participants in Studies That Include Belzutifan (MK-6482-043/LITESPARK-043)

Recruiting
NCT05319730Phase 1

A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)

Recruiting
NCT03486873Phase 3

Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

Recruiting
NCT07383441Phase 3

Adding Biotherapy or Placebo to Standard Treatment for Advanced Kidney Cancer

Recruiting
NCT06318286Phase 2

Study of Pembrolizumab Plus Chemotherapy With Lenvatinib for Malignant Pleural Mesothelioma

Active Not Recruiting
NCT06986785Phase 2

A Study of BL-B01D1 Monotherapy, BL-B01D1 in Combination With Lenvatinib, BL-B01D1 in Combination With PD-1 Monoclonal Antibody, and BL-B01D1 in Combination With PD-1 Monoclonal Antibody and Bevacizumab in Patients With Advanced Hepatocellular Carcinoma

Recruiting
NCT06880523Phase 2

STRIDE (Durvalumab + Tremelimumab) With Lenvatinib vs STRIDE Alone in Unresectable Hepatocellular Carcinoma

Recruiting
NCT07466225

HAIC Plus Lenva and PD-1 for Advanced HCC With Macrovascular or Biliary Invasion

Active Not Recruiting
NCT03516981Phase 2

A Study of Biomarker-Directed, Pembrolizumab (MK-3475) Based Combination Therapy for Advanced Non-Small Cell Lung Cancer (MK-3475-495/KEYNOTE-495)

Completed
NCT04955743Phase 2

Pembrolizumab and Lenvatinib in Patients With Brain Metastases From Melanoma or Renal Cell Carcinoma

Terminated
NCT04300556Phase 1

A Study to Evaluate the Safety, Tolerability, and Efficacy of MORAb-202 (Herein Referred to as Farletuzumab Ecteribulin), a Folate Receptor Alpha (FRα)-Targeting Antibody-drug Conjugate (ADC) in Participants With Selected Tumor Types

Recruiting
NCT04164199Phase 3

Study of Tislelizumab, Pamiparib, and Other Investigational Agents in Participants With Advanced Malignancies

Completed
NCT02780310Phase 2

Testing Lenvatinib in Patients With Adenoid Cystic Carcinoma

Active Not Recruiting
NCT04938817Phase 1

Safety and Efficacy Study of Investigational Agents as Monotherapy or in Combination With Pembrolizumab (MK-3475) for the Treatment of Extensive-Stage Small Cell Lung Cancer (ES-SCLC) in Need of Second-Line Therapy (MK-3475-B98/KEYNOTE-B98)

Active Not Recruiting
NCT04305054Phase 1

Substudy 02B: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With First Line (1L) Advanced Melanoma (MK-3475-02B/KEYMAKER-U02)

Completed
NCT07495579Phase 2

Lenvatinib or Regorafenib for Advanced Hepatocellular Carcinoma After Immunotherapy (REVIVE)

Not Yet Recruiting
NCT05585580Phase 2

Second-line Treatment With Serplulimab, Lenvatinib, and Paclitaxel in Advanced Gastric Cancer After Prior Immunotherapy

Active Not Recruiting
NCT07493668Phase 2

Fostrox Plus Lenvatinib vs Lenvatinib in Advanced Hepatocellular Carcinoma After First-line Immunotherapy

Recruiting
NCT06187961Phase 2

HAIC, Lenvatinib, and Cadonilimab as Conversion Therapy for Initially Unresectable Hepatocellular Carcinoma

Active Not Recruiting
NCT04626479Phase 1

Substudy 03A: A Study of Immune and Targeted Combination Therapies in Participants With First Line (1L) Renal Cell Carcinoma (MK-3475-03A)

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
349