Success Metrics

Clinical Success Rate
86.2%

Based on 112 completed trials

Completion Rate
86%(112/130)
Active Trials
129(35%)
Results Posted
70%(78 trials)
Terminated
18(5%)

Phase Distribution

Ph phase_2
198
54%
Ph phase_3
49
13%
Ph phase_4
5
1%
Ph early_phase_1
3
1%
Ph phase_1
75
20%
Ph not_applicable
18
5%

Phase Distribution

78

Early Stage

198

Mid Stage

54

Late Stage

Phase Distribution348 total trials
Early Phase 1First-in-human
3(0.9%)
Phase 1Safety & dosage
75(21.6%)
Phase 2Efficacy & side effects
198(56.9%)
Phase 3Large-scale testing
49(14.1%)
Phase 4Post-market surveillance
5(1.4%)
N/ANon-phased studies
18(5.2%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

75.2%

112 of 149 finished

Non-Completion Rate

24.8%

37 ended early

Currently Active

129

trials recruiting

Total Trials

368

all time

Status Distribution
Active(170)
Completed(112)
Terminated(37)
Other(49)

Detailed Status

Completed112
Recruiting80
Active, not recruiting49
unknown46
Not yet recruiting40
Withdrawn19

Development Timeline

Analytics

Development Status

Total Trials
368
Active
129
Success Rate
86.2%
Most Advanced
Phase 4

Trials by Phase

Early Phase 13 (0.9%)
Phase 175 (21.6%)
Phase 2198 (56.9%)
Phase 349 (14.1%)
Phase 45 (1.4%)
N/A18 (5.2%)

Trials by Status

suspended31%
terminated185%
enrolling_by_invitation10%
recruiting8022%
completed11230%
active_not_recruiting4913%
not_yet_recruiting4011%
unknown4613%
withdrawn195%

Recent Activity

Clinical Trials (368)

Showing 20 of 368 trialsScroll for more
NCT03486873Phase 3

Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

Recruiting
NCT04736706Phase 3

A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)

Active Not Recruiting
NCT05319730Phase 1

A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)

Recruiting
NCT07849660

Real-World Lenvatinib Sequencing in Unresectable Hepatocellular Carcinoma (uHCC)

Active Not Recruiting
NCT07847359Phase 2

Cryoablation Combined With Hepatic Arterial Infusion of Iparomlimab and Tuvonralimab (QL1706), Intravenous Dacarbazine, and Oral Lenvatinib in Patients With Liver Metastases From Malignant Melanoma: a Single-arm, Phase II, Prospective Trial

Recruiting
NCT05273554Phase 1

A Pilot Study to Assess Changes in Tumor Biology Following Second-line Treatment With Pembrolizumab Plus Lenvatinib in Patients With Advanced Pancreatic Ductal Adenocarcinoma

Completed
NCT06110793Phase 1

A Study of Lenvatinib, Pembrolizumab, and Fulvestrant in People With Breast Cancer

Active Not Recruiting
NCT07843901Phase 2

Lenvatinib in Patients With Advanced Parathyroid Carcinoma

Not Yet Recruiting
NCT05007106Phase 2

MK-7684A With or Without Other Anticancer Therapies in Participants With Selected Solid Tumors (MK-7684A-005) (KEYVIBE-005)

Completed
NCT04626518Phase 1

Substudy 03B: A Study of Immune and Targeted Combination Therapies in Participants With Second Line Plus (2L+) Renal Cell Carcinoma (MK-3475-03B/KEYMAKER-U03)

Completed
NCT04626479Phase 1

Substudy 03A: A Study of Immune and Targeted Combination Therapies in Participants With First Line (1L) Renal Cell Carcinoma (MK-3475-03A)

Completed
NCT07594015Phase 2

Pembrolizumab and Lenvatinib in Mismatch Repair Proficient Recurrent Endometrial Cancer After Progression on or Following First-Line Immunotherapy Maintenance

Recruiting
NCT05188118Early Phase 1

Rapid Sequencing of Approved Therapies in Patients With Metastatic or Unresectable Clear Cell Renal Cell Carcinoma

Completed
NCT07405164Phase 3

Extension Study for Participants in Studies That Include Belzutifan (MK-6482-043/LITESPARK-043)

Recruiting
NCT07835893Phase 2

Lenvatinib Plus Chemotherapy for pNET Liver Metastases

Recruiting
NCT07219459Phase 2

Visugromab, Nivolumab and Lenvatinib Compared to Double Placebo and Lenvatinib in Unresectable or Metastatic Hepatocellular Carcinoma Post Anti-PD-(L)1 Failure

Recruiting
NCT07836530Phase 3

Study Comparing BGB-B2033 With Sorafenib or Lenvatinib in Relapsed Hepatocellular Carcinoma

Not Yet Recruiting
NCT06858813Phase 1

A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused ABBV-324 in Adult Participants With Hepatocellular Cancer (HCC) or Squamous-Cell Non-Small Cell Lung Cancer (LUSC)

Recruiting
NCT07829926Phase 2

Lenvatinib Plus Tislelizumab With or Without Gefitinib for Advanced Liver Cancer

Not Yet Recruiting
NCT07829874Phase 2

Cryoablation Combined With QL1706 (Iparomlimab/Tuvonralimab) Plus Lenvatinib in Patients With Advanced Biliary Tract Cancer.

Not Yet Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
368