Success Metrics

Clinical Success Rate
87.8%

Based on 108 completed trials

Completion Rate
88%(108/123)
Active Trials
128(36%)
Results Posted
69%(75 trials)
Terminated
15(4%)

Phase Distribution

Ph early_phase_1
3
1%
Ph phase_1
74
21%
Ph phase_4
5
1%
Ph phase_2
189
53%
Ph not_applicable
18
5%
Ph phase_3
48
13%

Phase Distribution

77

Early Stage

189

Mid Stage

53

Late Stage

Phase Distribution337 total trials
Early Phase 1First-in-human
3(0.9%)
Phase 1Safety & dosage
74(22.0%)
Phase 2Efficacy & side effects
189(56.1%)
Phase 3Large-scale testing
48(14.2%)
Phase 4Post-market surveillance
5(1.5%)
N/ANon-phased studies
18(5.3%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

76.1%

108 of 142 finished

Non-Completion Rate

23.9%

34 ended early

Currently Active

128

trials recruiting

Total Trials

356

all time

Status Distribution
Active(164)
Completed(108)
Terminated(34)
Other(50)

Detailed Status

Completed108
Recruiting77
Active, not recruiting51
unknown47
Not yet recruiting35
Withdrawn19

Development Timeline

Analytics

Development Status

Total Trials
356
Active
128
Success Rate
87.8%
Most Advanced
Phase 4

Trials by Phase

Early Phase 13 (0.9%)
Phase 174 (22.0%)
Phase 2189 (56.1%)
Phase 348 (14.2%)
Phase 45 (1.5%)
N/A18 (5.3%)

Trials by Status

unknown4713%
not_yet_recruiting3510%
recruiting7722%
withdrawn195%
enrolling_by_invitation10%
terminated154%
completed10830%
active_not_recruiting5114%
suspended31%

Recent Activity

Clinical Trials (356)

Showing 20 of 356 trialsScroll for more
NCT04626479Phase 1

Substudy 03A: A Study of Immune and Targeted Combination Therapies in Participants With First Line (1L) Renal Cell Carcinoma (MK-3475-03A)

Active Not Recruiting
NCT04626518Phase 1

Substudy 03B: A Study of Immune and Targeted Combination Therapies in Participants With Second Line Plus (2L+) Renal Cell Carcinoma (MK-3475-03B/KEYMAKER-U03)

Active Not Recruiting
NCT05603910Phase 1

Phase 1 Clinical Trial of Lenvatinib, Pembrolizumab and Hypofractionated Pelvic Radiation Therapy for pMMR Recurrent/Unresectable Endometrial Carcinoma

Recruiting
NCT03486873Phase 3

Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

Recruiting
NCT05188118Early Phase 1

Rapid Sequencing of Approved Therapies in Patients With Metastatic or Unresectable Clear Cell Renal Cell Carcinoma

Completed
NCT05081180Phase 1

Study of Avelumab in Combination With Lenvatinib for Children With Primary CNS Tumors

Terminated
NCT05258279Phase 2

Lenvatinib in Combination With Carboplatin Pemetrexed and Pembrolizumab for NSCLC With EGFR Mutations

Completed
NCT05621499Not Applicable

HAIC or Lenvatinib Combined With Sintilimab for High Recurrence Risk Resectable Solitary Hepatocellular Carcinoma

Active Not Recruiting
NCT07405164Phase 3

Extension Study for Participants in Studies That Include Belzutifan (MK-6482-043/LITESPARK-043)

Recruiting
NCT06187961Phase 2

HAIC, Lenvatinib, and Cadonilimab as Conversion Therapy for Initially Unresectable Hepatocellular Carcinoma

Active Not Recruiting
NCT07219459Phase 2

Visugromab, Nivolumab and Lenvatinib Compared to Double Placebo and Lenvatinib in Unresectable or Metastatic Hepatocellular Carcinoma Post Anti-PD-(L)1 Failure

Recruiting
NCT07715565Phase 2

Ipilimumab N01 Plus Sintilimab and Lenvatinib as First-line Therapy for Locally Advanced or Metastatic TFE3-Rearranged Renal Cell Carcinoma: A Prospective, Multicenter, Single-Arm, Phase II Clinical Trial

Not Yet Recruiting
NCT04949256Phase 3

Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) Plus Chemotherapy in Participants With Metastatic Esophageal Carcinoma (MK-7902-014/E7080-G000-320/LEAP-014)

Completed
NCT05114421Phase 2

Pembrolizumab and Lenvatinib for the Treatment of Serous Ovarian Cancer Patients

Active Not Recruiting
NCT05041153Early Phase 1

Pembrolizumab and Lenvatinib for the Treatment of Advanced, Unresectable, or Metastatic Gastroesophageal Adenocarcinoma

Active Not Recruiting
NCT05273554Phase 1

A Pilot Study to Assess Changes in Tumor Biology Following Second-line Treatment With Pembrolizumab Plus Lenvatinib in Patients With Advanced Pancreatic Ductal Adenocarcinoma

Active Not Recruiting
NCT07686926Phase 2

Becotatug Vedotin Plus Tislelizumab and Low-Dose Lenvatinib for Advanced Esophageal Squamous Cell Carcinoma, Phase II

Not Yet Recruiting
NCT07704177Phase 2

Phase II Study of Trastuzumab Rezetecan Combined With Adebrelimab and Lenvatinib in Advanced HER2-Positive/Low-Expression Biliary Tract Cancer

Recruiting
NCT07691515Phase 3

Intraarterial Therapies Plus Tislelizumab Plus Lenvatinib Versus Tislelizumab Plus Gemcitabine-Cisplatin in Unresectable Intrahepatic Cholangiocarcinoma

Not Yet Recruiting
NCT06880523Phase 2

STRIDE (Durvalumab + Tremelimumab) With Lenvatinib vs STRIDE Alone in Unresectable Hepatocellular Carcinoma

Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
356