Success Metrics

Clinical Success Rate
87.2%

Based on 34 completed trials

Completion Rate
87%(34/39)
Active Trials
16(24%)
Results Posted
50%(17 trials)
Terminated
5(8%)

Phase Distribution

Ph early_phase_1
1
2%
Ph not_applicable
8
12%
Ph phase_1
13
20%
Ph phase_3
14
21%
Ph phase_4
14
21%
Ph phase_2
13
20%

Phase Distribution

14

Early Stage

13

Mid Stage

28

Late Stage

Phase Distribution63 total trials
Early Phase 1First-in-human
1(1.6%)
Phase 1Safety & dosage
13(20.6%)
Phase 2Efficacy & side effects
13(20.6%)
Phase 3Large-scale testing
14(22.2%)
Phase 4Post-market surveillance
14(22.2%)
N/ANon-phased studies
8(12.7%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

82.9%

34 of 41 finished

Non-Completion Rate

17.1%

7 ended early

Currently Active

16

trials recruiting

Total Trials

66

all time

Status Distribution
Active(17)
Completed(34)
Terminated(7)
Other(8)

Detailed Status

Completed34
Recruiting12
unknown8
Terminated5
Active, not recruiting4
Withdrawn2

Development Timeline

Analytics

Development Status

Total Trials
66
Active
16
Success Rate
87.2%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (1.6%)
Phase 113 (20.6%)
Phase 213 (20.6%)
Phase 314 (22.2%)
Phase 414 (22.2%)
N/A8 (12.7%)

Trials by Status

recruiting1218%
terminated58%
completed3452%
not_yet_recruiting12%
withdrawn23%
active_not_recruiting46%
unknown812%

Recent Activity

Clinical Trials (66)

Showing 20 of 66 trialsScroll for more
NCT04508790Phase 2

Leflunomide, Pomalidomide, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma

Recruiting
NCT05014646Phase 2

Leflunomide for the Treatment of High-Risk Smoldering Multiple Myeloma in African-American and European-American Patients

Active Not Recruiting
NCT06714461

A Study of the Effectiveness of Additional Risk Minimization Measures Related to ARAVA® (Leflunomide) in Saudi Arabia

Active Not Recruiting
NCT06454383Phase 1

Gemcitabine and Leflunomide in Patients With Advanced Unresectable Pancreatic Cancer

Recruiting
NCT03709446Phase 1

Leflunomide in Previously Treated Metastatic Triple Negative Cancers

Completed
NCT04370483Early Phase 1

Leflunomide for the Treatment of High-Risk Smoldering Multiple Myeloma

Active Not Recruiting
NCT03739853Phase 4

Severe Psoriatic Arthritis - Early intervEntion to Control Disease: the SPEED Trial

Completed
NCT07138898Phase 2

Immunosuppressant Management in Rheumatology Patients Undergoing Elective Total Shoulder Arthroplasty

Not Yet Recruiting
NCT03414502Phase 3

Treatment of Rheumatoid Arthritis With DMARDs: Predictors of Response

Recruiting
NCT04212416Phase 1

Leflunomide in Treating Patients With Steroid Dependent Chronic Graft Versus Host Disease

Active Not Recruiting
NCT05443425Phase 1

Leflunomide in Combination With Steroids for the Treatment of Acute Graft-versus-Host Disease After Donor Stem Cell Transplant for Hematologic Malignancies

Recruiting
NCT04997993Phase 1

Leflunomide in Patients With PTEN-Altered Advanced Solid Malignancies and HER2 Negative Breast Cancer

Recruiting
NCT04725422

CHronic Nonbacterial Osteomyelitis International Registry

Recruiting
NCT02451748Phase 4

IL-7 and IL-7R Expression in RA Patients With Active vs. Inactive Disease Treated With DMARD or CIMZIA

Completed
NCT04532372Phase 1

Leflunomide for the Treatment of Severe COVID-19 in Patients With a Concurrent Malignancy

Completed
NCT05789017Not Applicable

Treatment Strategies for IgG4-RD Patients With Internal Organ Involvement

Recruiting
NCT04361214Phase 1

Leflunomide in Mild COVID-19 Patients

Terminated
NCT06229340Phase 2

Leflunomide or Combination of MEK Inhibitor and Hydroxychloroquine for Refractory Patients With RAS Mutations

Recruiting
NCT04463615Phase 2

Leflunomide for the Treatment of Relapsed or Refractory CD30+ Lymphoproliferative Disorders

Completed
NCT01619176Not Applicable

Acupuncture Study on Rheumatoid Arthritis, Monitoring Microbiome and Blood

Completed

Drug Details

Intervention Type
DRUG
Total Trials
66