Success Metrics

Clinical Success Rate
100.0%

Based on 8 completed trials

Completion Rate
100%(8/8)
Active Trials
16(53%)
Results Posted
63%(5 trials)

Phase Distribution

Ph phase_2
16
53%
Ph phase_3
3
10%
Ph phase_1
8
27%

Phase Distribution

8

Early Stage

16

Mid Stage

3

Late Stage

Phase Distribution27 total trials
Phase 1Safety & dosage
8(29.6%)
Phase 2Efficacy & side effects
16(59.3%)
Phase 3Large-scale testing
3(11.1%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

100.0%

8 of 8 finished

Non-Completion Rate

0.0%

0 ended early

Currently Active

16

trials recruiting

Total Trials

30

all time

Status Distribution
Active(16)
Completed(8)
Other(6)

Detailed Status

Active, not recruiting8
Recruiting8
Completed8
unknown6

Development Timeline

Analytics

Development Status

Total Trials
30
Active
16
Success Rate
100.0%
Most Advanced
Phase 3

Trials by Phase

Phase 18 (29.6%)
Phase 216 (59.3%)
Phase 33 (11.1%)

Trials by Status

active_not_recruiting827%
unknown620%
recruiting827%
completed827%

Recent Activity

Clinical Trials (30)

Showing 20 of 30 trialsScroll for more
NCT04988295Phase 3

A Study of Amivantamab and Lazertinib in Combination With Platinum-Based Chemotherapy Compared With Platinum-Based Chemotherapy in Patients With Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non- Small Cell Lung Cancer After Osimertinib Failure

Active Not Recruiting
NCT04487080Phase 3

A Study of Amivantamab and Lazertinib Combination Therapy Versus Osimertinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Active Not Recruiting
NCT05663866Phase 2

Premedication to Reduce Amivantamab Associated Infusion Related Reactions

Active Not Recruiting
NCT06667076Phase 2

A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

Recruiting
NCT02609776Phase 1

Study of Amivantamab, a Human Bispecific EGFR and cMet Antibody, in Participants With Advanced Non-Small Cell Lung Cancer

Active Not Recruiting
NCT04077463Phase 1

A Study of Lazertinib as Monotherapy or in Combination With Amivantamab in Participants With Advanced Non-small Cell Lung Cancer

Active Not Recruiting
NCT05388669Phase 3

A Study of Lazertinib With Subcutaneous Amivantamab Compared With Intravenous Amivantamab in Participants With Epidermal Growth Factor Receptor (EGFR)-Mutated Advanced or Metastatic Non-small Cell Lung Cancer

Active Not Recruiting
NCT05498428Phase 2

A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer

Recruiting
NCT06120140Phase 2

Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus Lazertinib

Recruiting
NCT06106802Phase 2

Lazertinib & Tepotinib for EGFR Mutant NSCLC in MET Overexpressed or Amplified Who Progressed After Lazertinib Treatment

Recruiting
NCT06268210Phase 2

Neoadjuvant Lazertinib With or Without Chemotherapy for Patients With EGFR-mutated Resectable Non-small Cell Lung Cancer

Recruiting
NCT05601973Phase 2

Amivantamab, Lazertinib and Bevacizumab in Patients With EGFR-mutant Advanced Non-small Cell Lung Cancer With Progression on Previous Third-generation EGFR-TKI

Active Not Recruiting
NCT04965090Phase 2

A Study of Amivantamab and Lazertinib in People With Non-Small Cell Lung Cancer (NSCLC)

Completed
NCT05299125Phase 2

Amivantamab, Lazertinib, and Pemetrexed for First-line Treatment of Recurrent/Metastatic Non-small Cell Lung Cancers With Epidermal Growth Factor Receptor Mutations

Active Not Recruiting
NCT05541822Phase 2

To Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetic Profile of ABN401 in Patients With Advanced Solid Tumors Harboring c-MET Dysregulation

Recruiting
NCT04075396Phase 1

A Study of Lazertinib in Participants With Epidermal Growth Factor Receptor (EGFR) Mutation Positive Advanced Non-Small Cell Lung Cancer (NSCLC)

Completed
NCT05112952Phase 1

A Study to Evaluate the Effect of Hepatic Impairment on Lazertinib (JNJ-73841937)

Completed
NCT05896683Phase 1

A Study of Lazertinib (JNJ-73841937) Tablet in Healthy Adult Participants

Completed
NCT06156527Phase 2

A Randomized Phase II Study of LAZE rtiNib Alone Versus Lazertinib Plus bevaCizumab for NSCLC With EGFR + & Smoker

Recruiting
NCT06020989Phase 2

Lazertinib and Chemotherapy Combination in EGFR-mutant NSCLC Patients Without ctDNA Clearance After lead-in Lazertinib Monotherapy

Unknown

Drug Details

Intervention Type
DRUG
Total Trials
30