Success Metrics

Completion Rate
0%(0/2)
Active Trials
1(9%)
Terminated
2(18%)

Phase Distribution

Ph phase_1
7
64%
Ph phase_2
4
36%

Phase Distribution

7

Early Stage

4

Mid Stage

0

Late Stage

Phase Distribution11 total trials
Phase 1Safety & dosage
7(63.6%)
Phase 2Efficacy & side effects
4(36.4%)

Highest Phase Reached

Phase 2

Trial Status & Enrollment

Completion Rate

0.0%

0 of 2 finished

Non-Completion Rate

100.0%

2 ended early

Currently Active

1

trials recruiting

Total Trials

11

all time

Status Distribution
Active(1)
Terminated(2)
Other(8)

Detailed Status

unknown8
Terminated2
Recruiting1

Development Timeline

Analytics

Development Status

Total Trials
11
Active
1
Success Rate
0.0%
Most Advanced
Phase 2

Trials by Phase

Phase 17 (63.6%)
Phase 24 (36.4%)

Trials by Status

unknown873%
recruiting19%
terminated218%

Recent Activity

Clinical Trials (11)

Showing 11 of 11 trials
NCT04113616Phase 1

An Open-Label, Multicenter, Phase 1b/2 Study of the Safety and Efficacy of KRT-232 When Administered Alone and in Combination With Low-Dose Cytarabine (LDAC) or Decitabine in Patients With Acute Myeloid Leukemia (AML)

Terminated
NCT05027867Phase 2

KRT-232 in Subjects With Relapsed or Refractory Small Cell Lung Cancer

Terminated
NCT03662126Phase 2

KRT-232 Versus Best Available Therapy for the Treatment of Subjects With Myelofibrosis Who Are Relapsed or Refractory to JAK Inhibitor Treatment

Unknown
NCT03787602Phase 1

Navtemadlin (KRT-232) With or Without Anti-PD-1/Anti-PD-L1 for the Treatment of Patients With Merkel Cell Carcinoma

Unknown
NCT04669067Phase 1

TL-895 and KRT-232 Study in Acute Myeloid Leukemia

Unknown
NCT04502394Phase 1

Safety and Efficacy of KRT-232 in Combination With Acalabrutinib in Subjects With R/R DLBCL or R/R CLL

Unknown
NCT04878003Phase 2

Study of KRT-232 or TL-895 in Janus Associated Kinase Inhibitor Treatment-Naïve Myelofibrosis

Unknown
NCT04640532Phase 1

KRT-232 in Combination With TL-895 for the Treatment of R/R MF and KRT-232 for the Treatment of JAKi Intolerant MF

Unknown
NCT04485260Phase 1

An Open-Label, Multicenter, Phase 1b/2 Study of the Safety and Efficacy of KRT-232 Combined With Ruxolitinib in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera MF (Post-PV-MF), Or Post-Essential Thrombocythemia MF (Post ET-MF) Who Have a Suboptimal Response to Ruxolitinib

Unknown
NCT04835584Phase 1

KRT-232 and TKI Study in Chronic Myeloid Leukemia

Recruiting
NCT03669965Phase 2

KRT-232 Compared to Ruxolitinib in Patients With Phlebotomy-Dependent Polycythemia Vera

Unknown

All 11 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
11