Success Metrics

Clinical Success Rate
57.1%

Based on 4 completed trials

Completion Rate
57%(4/7)
Active Trials
23(72%)
Results Posted
150%(6 trials)
Terminated
3(9%)

Phase Distribution

Ph phase_3
2
6%
Ph not_applicable
2
6%
Ph phase_2
13
41%
Ph phase_1
14
44%

Phase Distribution

14

Early Stage

13

Mid Stage

2

Late Stage

Phase Distribution31 total trials
Phase 1Safety & dosage
14(45.2%)
Phase 2Efficacy & side effects
13(41.9%)
Phase 3Large-scale testing
2(6.5%)
N/ANon-phased studies
2(6.5%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

44.4%

4 of 9 finished

Non-Completion Rate

55.6%

5 ended early

Currently Active

23

trials recruiting

Total Trials

32

all time

Status Distribution
Active(23)
Completed(4)
Terminated(5)

Detailed Status

Recruiting18
Active, not recruiting5
Completed4
Terminated3
Withdrawn2

Development Timeline

Analytics

Development Status

Total Trials
32
Active
23
Success Rate
57.1%
Most Advanced
Phase 3

Trials by Phase

Phase 114 (45.2%)
Phase 213 (41.9%)
Phase 32 (6.5%)
N/A2 (6.5%)

Trials by Status

recruiting1856%
active_not_recruiting516%
withdrawn26%
terminated39%
completed413%

Recent Activity

Clinical Trials (32)

Showing 20 of 32 trialsScroll for more
NCT06265545Not Applicable

Multicenter, Platform-type Clinical Study of Refractory/Recurrent Acute Myeloid Leukemia

Recruiting
NCT06465953Phase 3

Ivosidenib (IVO) Monotherapy and Azacitidine (AZA) Monotherapy in Patients With Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS) With an IDH1 Mutation

Recruiting
NCT07548710Phase 2

Study of SA+X in the Treatment of Newly Diagnosed AML

Recruiting
NCT03155620Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

Active Not Recruiting
NCT07392242Phase 2

A Study of the Combination of Ivosidenib, Azacitidine, and Venetoclax Followed by Ivosidenib Alone in People With Acute Myeloid Leukemia

Recruiting
NCT05010772Phase 1

Decitabine Alone or in Combination With Venetoclax, Gilteritinib, Enasidenib, or Ivosidenib as Maintenance Therapy for the Treatment of Acute Myeloid Leukemia in Remission

Recruiting
NCT04195555Phase 2

Ivosidenib in Treating Patients With Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With IDH1 Mutations (A Pediatric MATCH Treatment Trial)

Active Not Recruiting
NCT05401097Phase 2

IDH Targeted/Non- Targeted vs Non-targeted/IDH-targeted Approaches in the Treatment of Newly Diagnosed IDH Mutated AML Patients Not Candidates for Intensive Induction Therapy (I- DATA Study)

Recruiting
NCT05756777Phase 1

A Study of Gilteritinib in Combination With Ivosidenib or Enasidenib in People With Acute Myeloid Leukemia (AML)

Recruiting
NCT06707493Phase 2

Ivosidenib as Post-HSCT Maintenance for AML

Recruiting
NCT04493164Phase 2

CPX-351 and Ivosidenib for the Treatment of IDH1 Mutated Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

Recruiting
NCT07260175Phase 2

Phase II Study Evaluating Ivosidenib Maintenance After SOC Adjuvant Chemotherapy in Curative mIDH1 Cholangiocarcinoma

Recruiting
NCT04250051Phase 1

Ivosidenib and Combination Chemotherapy for the Treatment of IDH1 Mutant Relapsed or Refractory Acute Myeloid Leukemia

Terminated
NCT07607418Phase 2

Ivosidenib as Maintenance Therapy in Transplant-Ineligible IDH1-mutated AML and HR-MDS

Recruiting
NCT04774393Phase 1

Decitabine/Cedazuridine and Venetoclax in Combination With Ivosidenib or Enasidenib for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

Recruiting
NCT05615818Phase 3

Personalized Medicine for Advanced Biliary Cancer Patients

Recruiting
NCT06501625Phase 1

Ivosidenib Plus Durvalumab and Gemcitabine/Cisplatin as First-Line Therapy in Participants With Locally Advanced or Metastatic Cholangiocarcinoma With an IDH1 Mutation

Recruiting
NCT05921760Phase 1

Ivosidenib, Nivolumab, and Ipilimumab Combination in Previously Treated Subjects With Nonresectable or Metastatic IDH1 Mutant Cholangiocarcinoma

Terminated
NCT03471260Phase 1

Ivosidenib and Venetoclax With or Without Azacitidine in Treating Patients With IDH1 Mutated Hematologic Malignancies

Recruiting
NCT06181734

Ivosidenib (TIBSOVO®) Combined With Azacitidine According to Current SmPC

Completed

Drug Details

Intervention Type
DRUG
Total Trials
32