Success Metrics

Clinical Success Rate
66.7%

Based on 4 completed trials

Completion Rate
67%(4/6)
Active Trials
22(73%)
Results Posted
150%(6 trials)
Terminated
2(7%)

Phase Distribution

Ph phase_2
12
40%
Ph not_applicable
1
3%
Ph phase_1
14
47%
Ph phase_3
2
7%

Phase Distribution

14

Early Stage

12

Mid Stage

2

Late Stage

Phase Distribution29 total trials
Phase 1Safety & dosage
14(48.3%)
Phase 2Efficacy & side effects
12(41.4%)
Phase 3Large-scale testing
2(6.9%)
N/ANon-phased studies
1(3.4%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

50.0%

4 of 8 finished

Non-Completion Rate

50.0%

4 ended early

Currently Active

22

trials recruiting

Total Trials

30

all time

Status Distribution
Active(22)
Completed(4)
Terminated(4)

Detailed Status

Recruiting16
Active, not recruiting6
Completed4
Terminated2
Withdrawn2

Development Timeline

Analytics

Development Status

Total Trials
30
Active
22
Success Rate
66.7%
Most Advanced
Phase 3

Trials by Phase

Phase 114 (48.3%)
Phase 212 (41.4%)
Phase 32 (6.9%)
N/A1 (3.4%)

Trials by Status

terminated27%
recruiting1653%
active_not_recruiting620%
completed413%
withdrawn27%

Recent Activity

Clinical Trials (30)

Showing 20 of 30 trialsScroll for more
NCT03155620Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

Active Not Recruiting
NCT04195555Phase 2

Ivosidenib in Treating Patients With Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With IDH1 Mutations (A Pediatric MATCH Treatment Trial)

Active Not Recruiting
NCT06707493Phase 2

Ivosidenib as Post-HSCT Maintenance for AML

Recruiting
NCT07548710Phase 2

Study of SA+X in the Treatment of Newly Diagnosed AML

Recruiting
NCT05921760Phase 1

Ivosidenib, Nivolumab, and Ipilimumab Combination in Previously Treated Subjects With Nonresectable or Metastatic IDH1 Mutant Cholangiocarcinoma

Terminated
NCT05756777Phase 1

A Study of Gilteritinib in Combination With Ivosidenib or Enasidenib in People With Acute Myeloid Leukemia (AML)

Recruiting
NCT07260175Phase 2

Phase II Study Evaluating Ivosidenib Maintenance After SOC Adjuvant Chemotherapy in Curative mIDH1 Cholangiocarcinoma

Recruiting
NCT03471260Phase 1

Ivosidenib and Venetoclax With or Without Azacitidine in Treating Patients With IDH1 Mutated Hematologic Malignancies

Recruiting
NCT07392242Phase 2

A Study of the Combination of Ivosidenib, Azacitidine, and Venetoclax Followed by Ivosidenib Alone in People With Acute Myeloid Leukemia

Recruiting
NCT06465953Phase 3

Ivosidenib (IVO) Monotherapy and Azacitidine (AZA) Monotherapy in Patients With Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS) With an IDH1 Mutation

Recruiting
NCT06181734

Ivosidenib (TIBSOVO®) Combined With Azacitidine According to Current SmPC

Completed
NCT05010772Phase 1

Decitabine Alone or in Combination With Venetoclax, Gilteritinib, Enasidenib, or Ivosidenib as Maintenance Therapy for the Treatment of Acute Myeloid Leukemia in Remission

Recruiting
NCT06501625Phase 1

Ivosidenib Plus Durvalumab and Gemcitabine/Cisplatin as First-Line Therapy in Participants With Locally Advanced or Metastatic Cholangiocarcinoma With an IDH1 Mutation

Recruiting
NCT07282262Phase 2

An Exploratory Study on the Use of Ivosidenib for the Precise Treatment of Advanced Biliary Tract Malignancies With IDH1 Mutations in the Later Line of Therapy.

Recruiting
NCT06081829Phase 2

A Phase 2 Study of Ivosidenib in Previously Treated Japanese Subjects With Nonresectable or Metastatic Cholangiocarcinoma With an IDH1 Mutation

Active Not Recruiting
NCT04493164Phase 2

CPX-351 and Ivosidenib for the Treatment of IDH1 Mutated Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

Recruiting
NCT03498521Phase 2

A Phase II Randomized Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Versus Platinum-Based Chemotherapy in Patients With Cancer of Unknown Primary Site

Completed
NCT04774393Phase 1

Decitabine/Cedazuridine and Venetoclax in Combination With Ivosidenib or Enasidenib for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

Recruiting
NCT06291987Phase 1

Ivosidenib and Ruxolitinib in Patients With Advanced Myeloproliferative Neoplasms (MPNs) That Have an IDH1 Gene Mutation

Recruiting
NCT03564821Phase 1

IDH1 Inhibition Using Ivosidenib as Maintenance Therapy for IDH1-mutant Myeloid Neoplasms Following Allogeneic Stem Cell Transplantation

Completed

Drug Details

Intervention Type
DRUG
Total Trials
30