Success Metrics

Clinical Success Rate
73.5%

Based on 280 completed trials

Completion Rate
73%(280/381)
Active Trials
191(30%)
Results Posted
88%(247 trials)
Terminated
101(16%)

Phase Distribution

Ph early_phase_1
9
1%
Ph phase_1
268
42%
Ph not_applicable
3
0%
Ph phase_2
287
45%
Ph phase_3
53
8%
Ph phase_4
6
1%

Phase Distribution

277

Early Stage

287

Mid Stage

59

Late Stage

Phase Distribution626 total trials
Early Phase 1First-in-human
9(1.4%)
Phase 1Safety & dosage
268(42.8%)
Phase 2Efficacy & side effects
287(45.8%)
Phase 3Large-scale testing
53(8.5%)
Phase 4Post-market surveillance
6(1.0%)
N/ANon-phased studies
3(0.5%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

68.1%

280 of 411 finished

Non-Completion Rate

31.9%

131 ended early

Currently Active

191

trials recruiting

Total Trials

638

all time

Status Distribution
Active(197)
Completed(280)
Terminated(131)
Other(30)

Detailed Status

Completed280
Active, not recruiting113
Terminated101
Recruiting78
Withdrawn30
unknown26

Development Timeline

Analytics

Development Status

Total Trials
638
Active
191
Success Rate
73.5%
Most Advanced
Phase 4

Trials by Phase

Early Phase 19 (1.4%)
Phase 1268 (42.8%)
Phase 2287 (45.8%)
Phase 353 (8.5%)
Phase 46 (1.0%)
N/A3 (0.5%)

Trials by Status

suspended41%
not_yet_recruiting61%
unknown264%
recruiting7812%
terminated10116%
withdrawn305%
active_not_recruiting11318%
completed28044%

Recent Activity

Clinical Trials (638)

Showing 20 of 638 trialsScroll for more
NCT03104439Phase 2

Nivolumab and Ipilimumab and Radiation Therapy in MSS and MSI High Colorectal and Pancreatic Cancer

Active Not Recruiting
NCT05904080Phase 2

Testing Nivolumab and Ipilimumab Immunotherapy With or Without the Targeted Drug Cabozantinib in Recurrent, Metastatic, or Incurable Nasopharyngeal Cancer

Recruiting
NCT05112601Phase 2

Testing Nivolumab With or Without Ipilimumab in Deficient Mismatch Repair System (dMMR) Recurrent Endometrial Carcinoma

Recruiting
NCT05896839Phase 1

Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer

Recruiting
NCT04495257Phase 1

A Study of APX005M in Combination With Nivolumab and Ipilimumab in Treatment Naïve Patients With Advanced Melanoma or Renal Cell Carcinoma (RCC)

Completed
NCT04290546Phase 1

CIML NK Cell in Head & Neck Cancer

Completed
NCT03816345Phase 1

Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

Recruiting
NCT07383441Phase 3

Adding Biotherapy or Placebo to Standard Treatment for Advanced Kidney Cancer

Recruiting
NCT03866382Phase 2

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

Recruiting
NCT06743126Phase 3

SUPRAME-ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma

Recruiting
NCT04500548Phase 1

Testing the Combination of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) in Children, Adolescent, and Young Adult Patients With Relapsed/Refractory Cancers That Have an Increased Number of Genetic Changes, The 3CI Study

Withdrawn
NCT02785952Phase 3

Lung-MAP: Nivolumab With or Without Ipilimumab as Second-Line Therapy in Treating Patients With Recurrent Stage IV Squamous Cell Lung Cancer and No Matching Biomarkers

Active Not Recruiting
NCT06097728Phase 3

MEDI5752 in Combination With Carboplatin Plus Pemetrexed in Unresectable Pleural Mesothelioma

Active Not Recruiting
NCT06377111Phase 1

A Study to Test the Benefit of Vitamin B5 in Patients With Melanoma

Active Not Recruiting
NCT07510334Phase 2

VSV-IFNβ-NIS With Ipilimumab and Nivolumab for the Treatment of Advanced or Metastatic Clear Cell Renal Cell Carcinoma

Recruiting
NCT07227012Phase 1

Symbiotic-GI-13: A Study to Learn About Study Medicine Called PF-08634404 as a Single Treatment and Combination Treatment in Adult Participants With a Liver Cancer Called Hepatocellular Carcinoma, That is Too Advanced to be Removed by Surgery and May Have Spread to Other Parts of the Body.

Recruiting
NCT07227415Phase 1

Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer

Recruiting
NCT03899155Phase 2

Pan Tumor Rollover Study

Recruiting
NCT02834013Phase 2

Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

Active Not Recruiting
NCT03958383Phase 1

IT-hu14.18-IL2 With Radiation, Nivolumab and Ipilimumab for Melanoma

Terminated

Drug Details

Intervention Type
DRUG
Total Trials
638