Success Metrics

Clinical Success Rate
74.0%

Based on 290 completed trials

Completion Rate
74%(290/392)
Active Trials
185(29%)
Results Posted
86%(250 trials)
Terminated
102(16%)

Phase Distribution

Ph phase_3
52
8%
Ph phase_2
289
45%
Ph phase_4
5
1%
Ph phase_1
272
42%
Ph early_phase_1
9
1%
Ph not_applicable
3
0%

Phase Distribution

281

Early Stage

289

Mid Stage

57

Late Stage

Phase Distribution630 total trials
Early Phase 1First-in-human
9(1.4%)
Phase 1Safety & dosage
272(43.2%)
Phase 2Efficacy & side effects
289(45.9%)
Phase 3Large-scale testing
52(8.3%)
Phase 4Post-market surveillance
5(0.8%)
N/ANon-phased studies
3(0.5%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

68.7%

290 of 422 finished

Non-Completion Rate

31.3%

132 ended early

Currently Active

185

trials recruiting

Total Trials

642

all time

Status Distribution
Active(190)
Completed(290)
Terminated(132)
Other(30)

Detailed Status

Completed290
Active, not recruiting112
Terminated102
Recruiting73
Withdrawn30
unknown24

Development Timeline

Analytics

Development Status

Total Trials
642
Active
185
Success Rate
74.0%
Most Advanced
Phase 4

Trials by Phase

Early Phase 19 (1.4%)
Phase 1272 (43.2%)
Phase 2289 (45.9%)
Phase 352 (8.3%)
Phase 45 (0.8%)
N/A3 (0.5%)

Trials by Status

not_yet_recruiting51%
unknown244%
withdrawn305%
suspended61%
active_not_recruiting11217%
completed29045%
recruiting7311%
terminated10216%

Recent Activity

Clinical Trials (642)

Showing 20 of 642 trialsScroll for more
NCT03719131Phase 2

Rituximab and Hyaluronidase Human in Patients With Advanced Melanoma Undergoing Nivolumab and Ipilimumab Therapy

Completed
NCT00586391Phase 1

CD19 Chimeric Receptor Expressing T Lymphocytes In B-Cell Non Hodgkin's Lymphoma, ALL & CLL

Active Not Recruiting
NCT06049576Phase 1

Nivolumab and Ipilimumab With and Without Camu Camu for the Treatment of Patients With Metastatic Renal Cell Carcinoma

Suspended
NCT06747845Phase 2

Maintenance Niraparib Plus Ipilimumab in Patients With Metastatic Pancreatic Adenocarcinoma Whose Disease Has Not Progressed on Platinum-Based Chemotherapy

Recruiting
NCT07852325Phase 1

Comparative Pharmacokinetics of SHR-8068 and Ipilimumab in Healthy Chinese Men

Completed
NCT04929041Phase 2

Testing the Addition of Radiation Therapy to the Usual Treatment (Immunotherapy With or Without Chemotherapy) for Advanced Stage Non-small Cell Lung Cancer Patients Who Are PD-L1 Negative

Active Not Recruiting
NCT01134614Phase 2

Ipilimumab With or Without Sargramostim in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery

Active Not Recruiting
NCT01274338Phase 3

Ipilimumab or High-Dose Interferon Alfa-2b in Treating Patients With High-Risk Stage III-IV Melanoma That Has Been Removed by Surgery

Active Not Recruiting
NCT02224781Phase 3

Dabrafenib and Trametinib Followed by Ipilimumab and Nivolumab or Ipilimumab and Nivolumab Followed by Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAFV600 Melanoma

Active Not Recruiting
NCT06365619Phase 2

Neoadjuvant Ipilimumab/Nivolumab for Patients With Recurrent, High Risk, Resectable Melanoma

Recruiting
NCT05176483Phase 1

Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors

Recruiting
NCT02339571Phase 2

A Phase II/III Trial of Nivolumab, Ipilimumab, and GM-CSF in Patients With Advanced Melanoma

Active Not Recruiting
NCT02506153Phase 3

Physician/Patient Choice of Either High-Dose Recombinant Interferon Alfa-2B or Ipilimumab, Versus Pembrolizumab in Treating Patients With Stage III-IV High Risk Melanoma That Has Been Removed by Surgery

Active Not Recruiting
NCT03793166Phase 3

Immunotherapy With Nivolumab and Ipilimumab Followed by Nivolumab or Nivolumab With Cabozantinib for Patients With Advanced Kidney Cancer, The PDIGREE Study

Active Not Recruiting
NCT03604991Phase 2

Nivolumab and Ipilimumab in Treating Patients With Esophageal and Gastroesophageal Junction Adenocarcinoma Undergoing Surgery

Suspended
NCT03026140Phase 2

Neoadjuvant Immune Checkpoint Inhibition and Novel IO Combinations in Early-stage Colon Cancer

Recruiting
NCT03866382Phase 2

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

Recruiting
NCT04751370Phase 2

Testing Nivolumab and Ipilimumab With Short-Course Radiation in Locally Advanced Rectal Cancer

Active Not Recruiting
NCT01896999Phase 1

Brentuximab Vedotin and Nivolumab With or Without Ipilimumab in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma

Active Not Recruiting
NCT07227012Phase 1

Symbiotic-GI-13: A Study to Learn About Study Medicine Called PF-08634404 as a Single Treatment and Combination Treatment in Adult Participants With a Liver Cancer Called Hepatocellular Carcinoma, That is Too Advanced to be Removed by Surgery and May Have Spread to Other Parts of the Body.

Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
642