Success Metrics

Clinical Success Rate
84.6%

Based on 22 completed trials

Completion Rate
85%(22/26)
Active Trials
19(39%)
Results Posted
91%(20 trials)
Terminated
4(8%)

Phase Distribution

Ph phase_1
23
47%
Ph phase_3
5
10%
Ph phase_2
21
43%

Phase Distribution

23

Early Stage

21

Mid Stage

5

Late Stage

Phase Distribution49 total trials
Phase 1Safety & dosage
23(46.9%)
Phase 2Efficacy & side effects
21(42.9%)
Phase 3Large-scale testing
5(10.2%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

81.5%

22 of 27 finished

Non-Completion Rate

18.5%

5 ended early

Currently Active

19

trials recruiting

Total Trials

49

all time

Status Distribution
Active(19)
Completed(22)
Terminated(5)
Other(3)

Detailed Status

Completed22
Active, not recruiting12
Recruiting7
Terminated4
unknown2
Suspended1

Development Timeline

Analytics

Development Status

Total Trials
49
Active
19
Success Rate
84.6%
Most Advanced
Phase 3

Trials by Phase

Phase 123 (46.9%)
Phase 221 (42.9%)
Phase 35 (10.2%)

Trials by Status

recruiting714%
suspended12%
unknown24%
active_not_recruiting1224%
terminated48%
withdrawn12%
completed2245%

Recent Activity

Clinical Trials (49)

Showing 20 of 49 trialsScroll for more
NCT05862285Phase 3

A Rollover Study for Participants Previously Enrolled in a Genentech and/or F. Hoffman-La Roche Sponsored Study

Recruiting
NCT05564377Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

Recruiting
NCT04802759Phase 1

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer

Recruiting
NCT04931342Phase 2

A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors

Active Not Recruiting
NCT02465060Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

Active Not Recruiting
NCT06400251Phase 2

Testing Ipatasertib as Potentially Targeted Treatment in Cancers With AKT Genetic Changes (MATCH - Subprotocol Z1K)

Active Not Recruiting
NCT05554380Phase 2

Study of Chemotherapy Plus Ipatasertib for People With Solid Tumors With PTEN/AKT Mutations, A ComboMATCH Treatment Trial

Suspended
NCT05172245Phase 1

Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer

Recruiting
NCT05172258Phase 2

Testing the Addition of an Anti-cancer Drug, Ipatasertib, to the Usual Immunotherapy Treatment (Pembrolizumab) in Patients With Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck

Active Not Recruiting
NCT05538897Phase 1

Testing the Addition of the AKT Inhibitor, Ipatasertib, to Treatment With the Hormonal Agent Megestrol Acetate for Recurrent or Metastatic Endometrial Cancers

Active Not Recruiting
NCT03337698Phase 1

A Study Of Multiple Immunotherapy-Based Treatment Combinations In Participants With Metastatic Non-Small Cell Lung Cancer (Morpheus- Non-Small Cell Lung Cancer)

Terminated
NCT05498896Phase 2

Investigate the Contribution of Ipatasertib to Neoadjuvant Chemotherapy Plus Atezolizumab in TNBC

Active Not Recruiting
NCT04589845Phase 2

Tumor-agnostic Precision Immuno-oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study

Active Not Recruiting
NCT04650581Phase 3

Fulvestrant and Ipatasertib for Advanced HER-2 Negative and Estrogen Receptor Positive (ER+) Breast Cancer Following Progression on First Line CDK 4/6 Inhibitor and Aromatase Inhibitor

Active Not Recruiting
NCT04486352Phase 1

A Study of Targeted Agents for Patients With Recurrent or Persistent Endometrial Cancer

Recruiting
NCT03424005Phase 1

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer

Recruiting
NCT04253561Phase 1

Ipatasertib + Pertuzumab +Trastuzumab in Advanced HER2+ PI3KCA-mutant Breast Cancer Patients

Completed
NCT05276973Phase 1

Testing the Addition of Ipatasertib to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) for Stage III or IV Epithelial Ovarian Cancer

Active Not Recruiting
NCT03498521Phase 2

A Phase II Randomized Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Versus Platinum-Based Chemotherapy in Patients With Cancer of Unknown Primary Site

Completed
NCT03280563Phase 1

A Study of Multiple Immunotherapy-Based Treatment Combinations in Hormone Receptor (HR)-Positive Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Breast Cancer

Completed

Drug Details

Intervention Type
DRUG
Total Trials
49