Success Metrics

Clinical Success Rate
76.5%

Based on 13 completed trials

Completion Rate
76%(13/17)
Active Trials
1(5%)
Results Posted
62%(8 trials)
Terminated
4(20%)

Phase Distribution

Ph phase_1
11
55%
Ph phase_2
9
45%

Phase Distribution

11

Early Stage

9

Mid Stage

0

Late Stage

Phase Distribution20 total trials
Phase 1Safety & dosage
11(55.0%)
Phase 2Efficacy & side effects
9(45.0%)

Highest Phase Reached

Phase 2

Trial Status & Enrollment

Completion Rate

68.4%

13 of 19 finished

Non-Completion Rate

31.6%

6 ended early

Currently Active

1

trials recruiting

Total Trials

20

all time

Status Distribution
Active(1)
Completed(13)
Terminated(6)

Detailed Status

Completed13
Terminated4
Withdrawn2
Active, not recruiting1

Development Timeline

Analytics

Development Status

Total Trials
20
Active
1
Success Rate
76.5%
Most Advanced
Phase 2

Trials by Phase

Phase 111 (55.0%)
Phase 29 (45.0%)

Trials by Status

withdrawn210%
completed1365%
active_not_recruiting15%
terminated420%

Recent Activity

Clinical Trials (20)

Showing 20 of 20 trials
NCT03333343Phase 1

Study of EGF816 in Combination With Selected Targeted Agents in EGFR-mutant NSCLC

Active Not Recruiting
NCT01737827Phase 2

Study Efficacy and Safety of INC280 in Patients With Advanced Hepatocellular Carcinoma.

Terminated
NCT03484923Phase 2

Study of Efficacy and Safety of Novel Spartalizumab Combinations in Patients With Previously Treated Unresectable or Metastatic Melanoma

Completed
NCT02159066Phase 2

LGX818 and MEK162 in Combination With a Third Agent (BKM120, LEE011, BGJ398 or INC280) in Advanced BRAF Melanoma

Completed
NCT02386826Phase 1

INC280 Combined With Bevacizumab in Patients With Glioblastoma Multiforme

Completed
NCT02019693Phase 2

A Phase 2 Study of the MET Kinase Inhibitor INC280 in Papillary Renal Cell Cancer

Completed
NCT02323126Phase 2

Study of Efficacy and Safety of Nivolumab in Combination With EGF816 and of Nivolumab in Combination With INC280 in Patients With Previously Treated Non-small Cell Lung Cancer

Terminated
NCT01911507Phase 1

INC280 and Erlotinib Hydrochloride in Treating Patients With Non-small Cell Lung Cancer

Completed
NCT01610336Phase 2

A Safety and Efficacy Study of INC280 and Gefitinib in Patients With EGFR Mutated, c-MET-amplified NSCLC Who Have Progressed After EGFRi Treatment

Completed
NCT01324479Phase 1

Study of INC280 in Patients With c-MET Dependent Advanced Solid Tumors

Completed
NCT02925104Phase 1

A Dose Escalation Study to Assess PK, Safety and Tolerability of INC280 When Taken With Food in cMET Dysregulated Advanced Solid Tumors.

Completed
NCT01546428Phase 1

A Phase I Study of INC280 in Japanese Patients With Advanced Solid Tumors

Completed
NCT02276027Phase 2

A Phase II, Open Label, Multiple Arm Study of AUY922, BYL719, INC280, LDK378 and MEK162 in Chinese Patients With Advanced Non-small Cell Lung Cancer

Completed
NCT02474537Phase 1

INC280 in Healthy Subjects With Impaired Hepatic Function and Subjects With Normal Hepatic Function

Completed
NCT02520752Phase 1

A DDI Study to Assess the Effect of INC280 on the PK of Midazolam and Caffeine in Patients With cMET-dysregulated Advanced Solid Tumors

Completed
NCT02626234Phase 1

A Drug-drug Interaction (DDI) Study to Assess the Effect of INC280 on the Pharmacokinetics of Digoxin and Rosuvastatin in Patients With cMET-dysregulated Advanced Solid Tumors

Completed
NCT02205398Phase 1

Study of Safety and Efficacy of INC280 and Cetuximab, in Adult c-MET Positive mCRC and HNSCC Patients After Progression on Cetuximab or Panitumumab Therapy

Terminated
NCT03240393Phase 2

Study of Oral cMET Inhibitor INC280 in Chinese Patients With EGFR Wild-type Advanced Non-small Cell Lung Cancer (NSCLC)

Withdrawn
NCT01870726Phase 1

Safety and Efficacy of INC280 and Buparlisib (BKM120) in Patients With Recurrent Glioblastoma

Terminated
NCT01964235Phase 2

Study of Efficacy and Safety INC280 in Patients With Advanced Hepatocellular Carcinoma

Withdrawn

All 20 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
20