Success Metrics

Clinical Success Rate
82.4%

Based on 89 completed trials

Completion Rate
82%(89/108)
Active Trials
24(16%)
Results Posted
44%(39 trials)
Terminated
19(13%)

Phase Distribution

Ph phase_2
64
42%
Ph phase_3
30
20%
Ph not_applicable
13
9%
Ph phase_4
5
3%
Ph early_phase_1
3
2%
Ph phase_1
31
20%

Phase Distribution

34

Early Stage

64

Mid Stage

35

Late Stage

Phase Distribution146 total trials
Early Phase 1First-in-human
3(2.1%)
Phase 1Safety & dosage
31(21.2%)
Phase 2Efficacy & side effects
64(43.8%)
Phase 3Large-scale testing
30(20.5%)
Phase 4Post-market surveillance
5(3.4%)
N/ANon-phased studies
13(8.9%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

78.1%

89 of 114 finished

Non-Completion Rate

21.9%

25 ended early

Currently Active

24

trials recruiting

Total Trials

152

all time

Status Distribution
Active(24)
Completed(89)
Terminated(25)
Other(14)

Detailed Status

Completed89
Terminated19
Recruiting14
unknown14
Active, not recruiting10
Withdrawn6

Development Timeline

Analytics

Development Status

Total Trials
152
Active
24
Success Rate
82.4%
Most Advanced
Phase 4

Trials by Phase

Early Phase 13 (2.1%)
Phase 131 (21.2%)
Phase 264 (43.8%)
Phase 330 (20.5%)
Phase 45 (3.4%)
N/A13 (8.9%)

Trials by Status

active_not_recruiting107%
completed8959%
recruiting149%
terminated1913%
unknown149%
withdrawn64%

Recent Activity

Clinical Trials (152)

Showing 20 of 152 trialsScroll for more
NCT05548062

Study to Identify and Describe Predictive Factors for Thromboembolic Events in Patients With High-risk Polycythemia Vera

Active Not Recruiting
NCT06871410Phase 1

Genetically Engineered Cells (CD83 CAR T Cells) for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

Recruiting
NCT00350844Phase 1

Hydroxyurea for Children and Young Adults With Sickle Cell Disease and Pulmonary Hypertension

Terminated
NCT07507760Phase 2

Oral Decitabine Plus Ivosidenib as First Line for Older/Unfit Adult AML Patients

Recruiting
NCT05953584Phase 2

A Phase 2 Open-label Study to Evaluate the Activity of Etavopivat on Transcranial Doppler Velocities in Pediatric Patients With Sickle Cell Disease Who Are at Increased Risk for Primary Stroke

Recruiting
NCT06456346Phase 3

Bomedemstat vs Hydroxyurea for Essential Thrombocythemia (MK-3543-007)

Active Not Recruiting
NCT06930352Phase 2

Ziftomenib for the Treatment of Patients With NPM1 Mutated or KMT2A Rearranged Acute Myeloid Leukemia Not Eligible for Standard Therapy

Recruiting
NCT05285917Phase 3

Promoting Utilization and Safety of Hydroxyurea Using Precision in Africa

Recruiting
NCT05853458Phase 4

Evaluation of HU-resistance in Adult Patients With Polycythemia Vera Who Meet PV-AIM Predictors

Terminated
NCT07033598Phase 2

Pacritinib vs. Hydroxyurea in Advanced Proliferative Chronic Myelomonocytic Leukemia

Recruiting
NCT03948867Phase 2

Stroke Prevention With Hydroxyurea Enabled Through Research and Education (SPHERE)

Active Not Recruiting
NCT03653338Phase 1

T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease (SCD) and Other Anemias

Recruiting
NCT03511118

Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants

Recruiting
NCT07616154Phase 2

Haploidentical Donor Hematopoietic Cell Transplant for Sickle Cell Disease

Recruiting
NCT03263559Phase 2

Haploidentical Bone Marrow Transplantation in Sickle Cell Patients (BMTCTN1507)

Completed
NCT04217356

Study of Stem Cell Transplant vs. Non-Transplant Therapies in High-Risk Myelofibrosis

Active Not Recruiting
NCT01966731Phase 1

Realizing Effectiveness Across Continents With Hydroxyurea (REACH)

Active Not Recruiting
NCT03077542Phase 1

Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease

Active Not Recruiting
NCT06171217Phase 2

Realizing Effectiveness Across Continents With Hydroxyurea

Active Not Recruiting
NCT05662098Early Phase 1

Alternative Dosing And Prevention of Transfusions (ADAPT)

Active Not Recruiting

Drug Details

Intervention Type
OTHER
Total Trials
152