Success Metrics

Clinical Success Rate
95.7%

Based on 90 completed trials

Completion Rate
96%(90/94)
Active Trials
4(4%)
Results Posted
42%(38 trials)
Terminated
4(4%)

Phase Distribution

Ph early_phase_1
2
2%
Ph not_applicable
16
14%
Ph phase_1
11
10%
Ph phase_2
11
10%
Ph phase_3
20
18%
Ph phase_4
44
40%

Phase Distribution

13

Early Stage

11

Mid Stage

64

Late Stage

Phase Distribution104 total trials
Early Phase 1First-in-human
2(1.9%)
Phase 1Safety & dosage
11(10.6%)
Phase 2Efficacy & side effects
11(10.6%)
Phase 3Large-scale testing
20(19.2%)
Phase 4Post-market surveillance
44(42.3%)
N/ANon-phased studies
16(15.4%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

90.9%

90 of 99 finished

Non-Completion Rate

9.1%

9 ended early

Currently Active

4

trials recruiting

Total Trials

111

all time

Status Distribution
Active(4)
Completed(90)
Terminated(9)
Other(8)

Detailed Status

Completed90
unknown8
Withdrawn5
Terminated4
Recruiting4

Development Timeline

Analytics

Development Status

Total Trials
111
Active
4
Success Rate
95.7%
Most Advanced
Phase 4

Trials by Phase

Early Phase 12 (1.9%)
Phase 111 (10.6%)
Phase 211 (10.6%)
Phase 320 (19.2%)
Phase 444 (42.3%)
N/A16 (15.4%)

Trials by Status

unknown87%
terminated44%
withdrawn55%
completed9081%
recruiting44%

Recent Activity

Clinical Trials (111)

Showing 20 of 111 trialsScroll for more
NCT03511118

Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants

Recruiting
NCT03892148Phase 4

Protocol of Diuretics Use in Congestive Therapy in Heart Failure

Completed
NCT05125224

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Dihydropyridine Calcium Channel Blockers Versus Hydrochlorothiazide

Completed
NCT04654312Phase 1

Study to Evaluate the Influence of Hydrochlorothiazide on Dermal Photosensitivity and DNA Stability - a Pilot Study (HCTox Study)

Completed
NCT04423627Early Phase 1

Sympathetic Regulation of Large Artery Stiffness in Humans With ISH

Completed
NCT02373163Phase 4

INTERVENCION Trial

Completed
NCT07020104Not Applicable

The Role of Skin Sodium Accumulation in Chronic Kidney Disease

Recruiting
NCT03476551

Bariatric Surgery and Pharmacokinetics of Hydrochlorothiazide

Recruiting
NCT04334824

Hydrochlorothiazide and Risk of Skin Cancer

Completed
NCT03109795Phase 4

Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous System

Terminated
NCT05917275Phase 4

Multi-Omics to Predict the Blood Pressure Response to Antihypertensives

Recruiting
NCT03179163Phase 1

Peripheral Vascular Effects of Sulfhydryl-containing Antihypertensive Pharmacotherapy on Microvessels in Humans

Terminated
NCT05443932Phase 4

Dapagliflozin and Hydrochlorothiazide in Recurring Kidney Stone Patients

Unknown
NCT02711670Not Applicable

Night Time Use of Thiazide Diuretics for Improved Reduction in Stone Risk in Stone Formers With Elevated Urine Calcium

Completed
NCT01983462Phase 2

Vascular Dysfunction in Human Obesity Hypertension

Terminated
NCT01647932Phase 3

Safety and Efficacy of the Combination of Loop With Thiazide-type Diuretics in Patients With Decompensated Heart Failure

Completed
NCT03461003Phase 4

N-of-1 Trials In Children With Hypertension

Completed
NCT03387657Phase 1

A Drug to Drug Interaction Study of Sotagliflozin With Hydrochlorothiazide

Completed
NCT00667719Phase 3

A Long Term Safety Study to Test the Combination of Aliskiren/ Amlodipine / Hydrochlorothiazide in Participants With Essential Hypertension

Completed
NCT02699125Phase 4

Treatment of OSA Associated Hypertension With Alpha 2 Agonist or Diuretic

Completed

Drug Details

Intervention Type
DRUG
Total Trials
111