Success Metrics

Clinical Success Rate
75.0%

Based on 3 completed trials

Completion Rate
75%(3/4)
Active Trials
1(14%)
Results Posted
0%(0 trials)
Terminated
1(14%)

Phase Distribution

Ph phase_1
5
71%
Ph phase_2
2
29%

Phase Distribution

5

Early Stage

2

Mid Stage

0

Late Stage

Phase Distribution7 total trials
Phase 1Safety & dosage
5(71.4%)
Phase 2Efficacy & side effects
2(28.6%)

Highest Phase Reached

Phase 2

Trial Status & Enrollment

Completion Rate

75.0%

3 of 4 finished

Non-Completion Rate

25.0%

1 ended early

Currently Active

1

trials recruiting

Total Trials

7

all time

Status Distribution
Active(1)
Completed(3)
Terminated(1)
Other(2)

Detailed Status

Completed3
unknown2
Recruiting1
Terminated1

Development Timeline

Analytics

Development Status

Total Trials
7
Active
1
Success Rate
75.0%
Most Advanced
Phase 2

Trials by Phase

Phase 15 (71.4%)
Phase 22 (28.6%)

Trials by Status

recruiting114%
terminated114%
unknown229%
completed343%

Recent Activity

1 active trials
Showing 5 of 7
completedphase_1

Study on [14C]HMPL-453（FGFR Inhibitor） in Healthy Chinese Adult Male Subjects

NCT07644442
completedphase_1

A Phase Ib/II Clinical Study Evaluating HMPL-453 Tartrate as Monotherapy and in Combination With Chemotherapy or Toripalimab in Advanced Solid Tumors

NCT05173142
recruitingphase_2

HMPL-453 Tartrate in Advanced Intrahepatic Cholangiocarcinoma

NCT04353375
completedphase_1

HMPL-453 Food Effect and PPI Study in Healthy Volunteer Study

NCT05930119
unknownphase_2

HMPL-453 in Advanced Malignant Mesothelioma

NCT04290325
View all 7 trials

Clinical Trials (7)

Showing 7 of 7 trials
NCT07644442Phase 1

Study on [14C]HMPL-453（FGFR Inhibitor） in Healthy Chinese Adult Male Subjects

Completed
NCT05173142Phase 1

A Phase Ib/II Clinical Study Evaluating HMPL-453 Tartrate as Monotherapy and in Combination With Chemotherapy or Toripalimab in Advanced Solid Tumors

Completed
NCT04353375Phase 2

HMPL-453 Tartrate in Advanced Intrahepatic Cholangiocarcinoma

Recruiting
NCT05930119Phase 1

HMPL-453 Food Effect and PPI Study in Healthy Volunteer Study

Completed
NCT04290325Phase 2

HMPL-453 in Advanced Malignant Mesothelioma

Unknown
NCT03160833Phase 1

A Study of HMPL-453 in Patients With Advanced Solid Malignancies

Unknown
NCT02966171Phase 1

A Dose Escalation Study to Assess the Safety and Tolerability of HMPL-453 in Patients With Advanced Solid Malignancies

Terminated

All 7 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
7