Success Metrics

Clinical Success Rate
72.7%

Based on 8 completed trials

Completion Rate
73%(8/11)
Active Trials
16(46%)
Results Posted
100%(8 trials)
Terminated
3(9%)

Phase Distribution

Ph early_phase_1
3
9%
Ph not_applicable
1
3%
Ph phase_1
14
40%
Ph phase_2
15
43%
Ph phase_3
2
6%

Phase Distribution

17

Early Stage

15

Mid Stage

2

Late Stage

Phase Distribution35 total trials
Early Phase 1First-in-human
3(8.6%)
Phase 1Safety & dosage
14(40.0%)
Phase 2Efficacy & side effects
15(42.9%)
Phase 3Large-scale testing
2(5.7%)
N/ANon-phased studies
1(2.9%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

57.1%

8 of 14 finished

Non-Completion Rate

42.9%

6 ended early

Currently Active

16

trials recruiting

Total Trials

35

all time

Status Distribution
Active(18)
Completed(8)
Terminated(6)
Other(3)

Detailed Status

Recruiting10
Completed8
Active, not recruiting6
Terminated3
Withdrawn3
unknown3

Development Timeline

Analytics

Development Status

Total Trials
35
Active
16
Success Rate
72.7%
Most Advanced
Phase 3

Trials by Phase

Early Phase 13 (8.6%)
Phase 114 (40.0%)
Phase 215 (42.9%)
Phase 32 (5.7%)
N/A1 (2.9%)

Trials by Status

terminated39%
not_yet_recruiting26%
withdrawn39%
active_not_recruiting617%
unknown39%
completed823%
recruiting1029%

Recent Activity

Clinical Trials (35)

Showing 20 of 35 trialsScroll for more
NCT06172296Phase 3

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

Recruiting
NCT04214249Phase 2

BLAST MRD AML-1: BLockade of PD-1 Added to Standard Therapy to Target Measurable Residual Disease in Acute Myeloid Leukemia 1- A Randomized Phase 2 Study of Anti-PD-1 Pembrolizumab in Combination With Intensive Chemotherapy as Frontline Therapy in Patients With Acute Myeloid Leukemia

Active Not Recruiting
NCT06859424Phase 2

A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation

Recruiting
NCT04375631Phase 1

CLAG-M or FLAG-Ida Chemotherapy and Reduced-Intensity Conditioning Donor Stem Cell Transplant for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelomonocytic Leukemia

Recruiting
NCT04708054Phase 2

Venetoclax to Improve Outcomes of Fractionated Busulfan Regimen in Patients With High-Risk AML and MDS

Recruiting
NCT04262843Phase 2

Total Marrow and Lymphoid Irradiation as Conditioning Regimen Before Hematopoietic Cell Transplantation in Patients With Myelodysplastic Syndrome or Acute Leukemia

Active Not Recruiting
NCT04994808Phase 2

Treosulfan-Based Versus Clofarabine-Based Conditioning Before Donor Hematopoietic Stem Cell Transplant for the Treatment of Myelodysplastic Syndromes or Acute Myeloid Leukemia

Active Not Recruiting
NCT07358195Early Phase 1

Addition of Venetoclax to Combined Hematopoietic Stem Cell and Kidney Transplantation

Not Yet Recruiting
NCT05384756Phase 1

TMLI and Alemtuzumab for Treatment of Sickle Cell Disease

Active Not Recruiting
NCT04083183Phase 1

Total Body Irradiation and Astatine-211-Labeled BC8-B10 Monoclonal Antibody for the Treatment of Nonmalignant Diseases

Recruiting
NCT03317899Phase 2

Stem Cell Transplant With or Without Tbo-filgrastim in Treating Patients With Multiple Myeloma or Non-Hodgkin Lymphoma

Completed
NCT06928662Phase 1

Chemotherapy (Decitabine in Combination With FLAG-Ida) and Total-Body Irradiation Followed by Donor Stem Cell Transplant for the Treatment of Adults With Myeloid Malignancies at High Risk of Relapse

Recruiting
NCT06128070Phase 2

Ruxolitinib With Tacrolimus and Methotrexate for the Prevention of Graft Versus Host Disease in Pediatric and Young Adult Patients Undergoing Allogeneic Hematopoietic Cell Transplant for Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndrome

Recruiting
NCT05031897Phase 2

Two Step Haplo With Radiation Conditioning

Recruiting
NCT04281199Phase 1

TBI Using IMRT (VMAT or Tomotherapy) for the Prevention of Pul Toxicities in Patients Undergoing Donor SCT

Active Not Recruiting
NCT05039073Phase 2

Brentuximab Vedotin and Nivolumab for the Treatment of Relapsed/Refractory Classic Hodgkin Lymphoma Previously Treated With Brentuximab Vedotin or Checkpoint Inhibitors

Recruiting
NCT06287944Phase 1

225Ac-DOTA-Anti-CD38 Daratumumab Monoclonal Antibody With Fludarabine, Melphalan and Total Marrow and Lymphoid Irradiation as Conditioning Treatment for Donor Stem Cell Transplant in Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia and Myelodysplastic Syndrome

Recruiting
NCT06996119Phase 1

Emapalumab With Post-Transplant Cyclophosphamide, Tacrolimus and Mycophenolate Mofetil for the Prevention of Graft-versus-Host Disease After Donor Reduced-Intensity Hematopoietic Cell Transplant

Not Yet Recruiting
NCT03583424Phase 1

Venetoclax, Carmustine, Etoposide, Cytarabine, and Melphalan Before Stem Cell Transplant in Treating Participants With Relapsed or Refractory Non-Hodgkin Lymphoma

Completed
NCT04521946Phase 1

Chemotherapy and Donor Stem Transplant for the Treatment of Patients With High Grade Brain Cancer

Withdrawn

Drug Details

Intervention Type
PROCEDURE
Total Trials
35