Success Metrics

Clinical Success Rate
94.4%

Based on 17 completed trials

Completion Rate
94%(17/18)
Active Trials
0(0%)
Results Posted
100%(17 trials)
Terminated
1(6%)

Phase Distribution

Ph phase_2
12
67%
Ph phase_1
4
22%

Phase Distribution

4

Early Stage

12

Mid Stage

0

Late Stage

Phase Distribution16 total trials
Phase 1Safety & dosage
4(25.0%)
Phase 2Efficacy & side effects
12(75.0%)

Highest Phase Reached

Phase 2

Trial Status & Enrollment

Completion Rate

94.4%

17 of 18 finished

Non-Completion Rate

5.6%

1 ended early

Currently Active

0

trials recruiting

Total Trials

18

all time

Status Distribution
Completed(17)
Terminated(1)

Detailed Status

Completed17
Terminated1

Development Timeline

Analytics

Development Status

Total Trials
18
Active
0
Success Rate
94.4%
Most Advanced
Phase 2

Trials by Phase

Phase 14 (25.0%)
Phase 212 (75.0%)

Trials by Status

terminated16%
completed1794%

Recent Activity

Clinical Trials (18)

Showing 18 of 18 trials
NCT01353911Phase 2

Grazoprevir (MK-5172) Administered With Peginterferon and Ribavirin in Treatment-Naïve Participants With Chronic Hepatitis C (MK-5172-003)

Completed
NCT01440595Phase 2

Grazoprevir (MK-5172) With Peg-Interferon and Ribavirin in Participants With Chronic Genotype 2 or 3 Hepatitis C (MK-5172-012)

Terminated
NCT02333292

Efficacy and Safety of Therapy Against HCV Based on Direct-acting Antivirals in Real-life Conditions

Completed
NCT01667081

Durability of Virologic Response and/or Viral Resistance Patterns in Participants With Chronic Hepatitis C Who Have Been Previously Treated With Grazoprevir (MK-5172) (MK-5172-017)

Completed
NCT01717326Phase 2

A Study of the Combination Regimen Grazoprevir (MK-5172) and Elbasvir (MK-8742) ± Ribavirin in Participants With Chronic Hepatitis C (MK-5172-035)

Completed
NCT01932762Phase 2

Efficacy and Safety of Combination Grazoprevir (MK-5172) + Elbasvir (MK-8742) + Ribavirin (RBV) in Genotype 2 Hepatitis C Infection (MK-5172-047)

Completed
NCT01710501Phase 2

A Study of Different Doses of Grazoprevir (MK-5172) Given With Pegylated Interferon Alfa-2b and Ribavirin to Treatment-Naïve Participants With Chronic Hepatitis C (MK-5172-038)

Completed
NCT02601573Phase 2

Elbasvir/Grazoprevir (EBR/GZR) and Sofosbuvir (SOF) With and Without Ribavirin (RBV) in Cirrhotic Subjects With Chronic Hepatitis C Virus (HCV) Genotype 3 (GT3) Infection (MK-5172-083)

Completed
NCT02332720Phase 2

Efficacy and Safety of Grazoprevir (MK-5172) and Uprifosbuvir (MK-3682) With Elbasvir (MK-8742) or Ruzasvir (MK-8408) for Chronic Hepatitis C Virus (HCV) Genotype (GT) 3, GT4, GT5, and GT6 Infection (MK-3682-012)

Completed
NCT02332707Phase 2

Efficacy and Safety of Grazoprevir (MK-5172) and Uprifosbuvir (MK-3682) With Elbasvir (MK-8742) or Ruzasvir (MK-8408) for Chronic Hepatitis C Genotype (GT)1 and GT2 Infection (MK-3682-011)

Completed
NCT02115321Phase 2

Study of Efficacy and Safety of Grazoprevir (MK-5172) + Elbasvir (MK-8742) in Chronic Hepatitis C Participants With Child-Pugh (CP)-B Hepatic Insufficiency (MK-5172-059)

Completed
NCT01937975Phase 1

The Pharmacokinetics of Grazoprevir (MK-5172) and Elbasvir (MK-8742) in Participants With Renal Insufficiency (MK-5172-050)

Completed
NCT02203149Phase 2

Study of Grazoprevir (MK-5172) and Elbasvir (MK-8742) in Japanese Participants With Chronic Hepatitis C (MK-5172-058)

Completed
NCT01716156Phase 2

A Study of Different Durations of Treatment With Grazoprevir (MK-5172) in Combination With Ribavirin in Participants With Chronic Hepatitis C (MK-5172-039)

Completed
NCT02092350Phase 2

Safety and Efficacy of Grazoprevir (MK-5172) + Elbasvir (MK-8742) in Participants With Chronic Hepatitis C and Chronic Kidney Disease (MK-5172-052)

Completed
NCT01390428Phase 1

Study to Investigate the Influence of Hepatic Insufficiency on the Pharmacokinetics of Grazoprevir (MK-5172-013)

Completed
NCT01537900Phase 1

A Multiple Dose Study of Grazoprevir (MK-5172) in Hepatitis C-Infected Participants (MK-5172-010)

Completed
NCT00998985Phase 1

A Study of Grazoprevir (MK-5172) in Hepatitis C-Infected Male Participants (MK-5172-004)

Completed

All 18 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
18