Success Metrics

Clinical Success Rate
53.8%

Based on 7 completed trials

Completion Rate
54%(7/13)
Active Trials
0(0%)
Results Posted
71%(5 trials)
Terminated
6(43%)

Phase Distribution

Ph phase_1
11
79%
Ph phase_2
3
21%

Phase Distribution

11

Early Stage

3

Mid Stage

0

Late Stage

Phase Distribution14 total trials
Phase 1Safety & dosage
11(78.6%)
Phase 2Efficacy & side effects
3(21.4%)

Highest Phase Reached

Phase 2

Trial Status & Enrollment

Completion Rate

50.0%

7 of 14 finished

Non-Completion Rate

50.0%

7 ended early

Currently Active

0

trials recruiting

Total Trials

14

all time

Status Distribution
Completed(7)
Terminated(7)

Detailed Status

Completed7
Terminated6
Withdrawn1

Development Timeline

Analytics

Development Status

Total Trials
14
Active
0
Success Rate
53.8%
Most Advanced
Phase 2

Trials by Phase

Phase 111 (78.6%)
Phase 23 (21.4%)

Trials by Status

completed750%
terminated643%
withdrawn17%

Recent Activity

Clinical Trials (14)

Showing 14 of 14 trials
NCT01217411Phase 1

RO4929097 and Whole-Brain Radiation Therapy or Stereotactic Radiosurgery in Treating Patients With Brain Metastases From Breast Cancer

Terminated
NCT01196416Phase 1

Gamma-secretase/Notch Signalling Pathway Inhibitor RO4929097 in Combination With Cisplatin, Vinblastine, and Temozolomide in Treating Patients With Recurrent or Metastatic Melanoma

Completed
NCT01154452Phase 1

Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma

Completed
NCT01251172Phase 2

RO4929097 After Autologous Stem Cell Transplant in Treating Patients With Multiple Myeloma

Withdrawn
NCT01175343Phase 2

RO4929097 in Treating Patients With Recurrent and/or Metastatic Epithelial Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer

Completed
NCT01141569Phase 2

A Study of RO4929097 in Patients With Advanced Renal Cell Carcinoma That Have Failed Vascular Endothelial Growth Factor (VEGF)/Vascular Endothelial Growth Factor Receptor (VEGFR) Therapy

Completed
NCT01119599Phase 1

RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma

Completed
NCT01193881Phase 1

RO4929097 and Erlotinib Hydrochloride in Treating Patients With Stage IV or Recurrent Non-small Cell Lung Cancer

Terminated
NCT01238133Phase 1

Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097, Paclitaxel, and Carboplatin Before Surgery in Treating Patients With Stage II or Stage III Triple-Negative Breast Cancer

Terminated
NCT01149356Phase 1

RO4929097 And Exemestane in Treating Pre- and Postmenopausal Patients With Advanced or Metastatic Breast Cancer

Terminated
NCT01198535Phase 1

Phase I Study of Cetuximab With RO4929097 in Metastatic Colorectal Cancer

Terminated
NCT01071564Phase 1

RO4929097 and Vismodegib in Treating Patients With Breast Cancer That is Metastatic or Cannot Be Removed By Surgery

Terminated
NCT01131234Phase 1

Gamma-Secretase Inhibitor RO4929097 and Cediranib Maleate in Treating Patients With Advanced Solid Tumors

Completed
NCT01218620Phase 1

Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced Solid Tumors

Completed

All 14 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
14