Success Metrics

Clinical Success Rate
92.6%

Based on 25 completed trials

Completion Rate
93%(25/27)
Active Trials
1(4%)
Results Posted
92%(23 trials)
Terminated
2(7%)

Phase Distribution

Ph phase_3
18
64%
Ph phase_2
5
18%
Ph phase_4
1
4%
Ph phase_1
4
14%

Phase Distribution

4

Early Stage

5

Mid Stage

19

Late Stage

Phase Distribution28 total trials
Phase 1Safety & dosage
4(14.3%)
Phase 2Efficacy & side effects
5(17.9%)
Phase 3Large-scale testing
18(64.3%)
Phase 4Post-market surveillance
1(3.6%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

92.6%

25 of 27 finished

Non-Completion Rate

7.4%

2 ended early

Currently Active

1

trials recruiting

Total Trials

28

all time

Status Distribution
Active(1)
Completed(25)
Terminated(2)

Detailed Status

Completed25
Terminated2
Recruiting1

Development Timeline

Analytics

Development Status

Total Trials
28
Active
1
Success Rate
92.6%
Most Advanced
Phase 4

Trials by Phase

Phase 14 (14.3%)
Phase 25 (17.9%)
Phase 318 (64.3%)
Phase 41 (3.6%)

Trials by Status

recruiting14%
completed2589%
terminated27%

Recent Activity

Clinical Trials (28)

Showing 20 of 28 trialsScroll for more
NCT07044297Phase 3

A Clinical Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-011)

Recruiting
NCT04652700Phase 3

Oral Islatravir (MK-8591) Once-Monthly as Preexposure Prophylaxis (PrEP) in Men and Transgender Women Who Are at High Risk for HIV-1 Infection (MK-8591-024)

Terminated
NCT04644029Phase 3

Oral ISL QM as PrEP in Cisgender Women at High Risk for HIV-1 Infection (MK-8591-022)

Terminated
NCT06816043Phase 1

A Study of Emtricitabine/Tenofovir Disoproxil Fumarate (FTC/TDF) and MK-8527 in Healthy Participants

Completed
NCT03464266Phase 4

The Kampala Women's Bone Study

Completed
NCT03593655Phase 2

Evaluating the Safety of and Adherence to a Vaginal Matrix Ring Containing Dapivirine and Oral Emtricitabine/Tenofovir Disoproxil Fumarate in an Adolescent and Young Adult Female Population

Completed
NCT02269917Phase 3

Study to Evaluate Efficacy and Safety of Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (D/C/F/TAF) Regimen Versus Boosted Protease Inhibitor (bPI) Along With Emtricitabine/Tenofovir Disoproxil Fumarate (FTC/TDF) Regimen in Virologically-Suppressed, HIV-1 Infected Participants

Completed
NCT01815736Phase 3

Study to Evaluate Switching From a TDF-Containing Combination Regimen to a TAF-Containing Fixed Dose Combination (FDC) in Virologically-Suppressed, HIV-1 Positive Participants

Completed
NCT02603107Phase 3

Study to Evaluate the Safety and Efficacy of Switching From Regimens Consisting of Boosted Atazanavir or Darunavir Plus Either Emtricitabine/Tenofovir or Abacavir/Lamivudine to Bictegravir/Emtricitabine/Tenofovir Alafenamide in Virologically Suppressed HIV-1 Infected Adults

Completed
NCT02121795Phase 3

Switch Study to Evaluate F/TAF in HIV-1 Positive Participants Who Are Virologically Suppressed on Regimens Containing FTC/TDF

Completed
NCT02616783Phase 3

Switching From a Tenofovir Disoproxil Fumarate (TDF) Containing Regimen to Elvitegravir/Cobicistat/Emtricitabine/ Tenofovir Alafenamide (E/C/F/TAF) Fixed-Dose Combination (FDC) in Virologically-Suppressed, HIV-1 Infected Adults Aged ≥ 60 Years

Completed
NCT02652624Phase 3

Safety and Efficacy of Switching to a FDC of B/F/TAF From E/C/F/TAF, E/C/F/TDF, or ATV+RTV+FTC/TDF in Virologically Suppressed HIV-1 Infected Women

Completed
NCT01705574Phase 3

Safety and Efficacy of E/C/F/TDF Versus RTV-Boosted ATV Plus FTC/TDF in HIV-1 Infected, Antiretroviral Treatment-Naive Women

Completed
NCT00936715Phase 2

Rollover Protocol Continued Access to Emtricitabine/Tenofovir Disoproxil Fumarate for Adults in United States

Completed
NCT00116805Phase 3

A Study to Compare Tenofovir Disoproxil Fumarate Versus Adefovir Dipivoxil for the Treatment of HBeAg-Positive Chronic Hepatitis B

Completed
NCT00117676Phase 3

A Study to Compare Tenofovir Disoproxil Fumarate Versus Adefovir Dipivoxil for the Treatment of HBeAg-Negative Chronic Hepatitis B

Completed
NCT01475838Phase 3

Study to Evaluate Switching From Regimens Consisting of a Ritonavir-boosted Protease Inhibitor Plus Emtricitabine/Tenofovir Fixed-Dose Combination to the Elvitegravir/Cobicistat/Emtricitabine/Tenofovir DF Single-Tablet Regimen in Virologically Suppressed, HIV-1 Infected Patients

Completed
NCT01108510Phase 3

Safety and Efficacy of COBI-boosted Atazanavir Versus Ritonavir-boosted Atazanavir Each Administered With Emtricitabine/Tenofovir Disoproxil Fumarate in HIV-1 Infected, Antiretroviral Treatment-Naive Adults

Completed
NCT01565850Phase 2

D/C/F/TAF Versus COBI-boosted DRV Plus FTC/TDF in HIV-1 Infected, Antiretroviral Treatment Naive Adults

Completed
NCT00737568Phase 3

Tenofovir Disoproxil Fumarate (Tenofovir DF) Versus Emtricitabine/Tenofovir DF in Subjects Resistant to Lamivudine

Completed

Drug Details

Intervention Type
DRUG
Total Trials
28