Success Metrics

Clinical Success Rate
85.7%

Based on 6 completed trials

Completion Rate
86%(6/7)
Active Trials
5(38%)
Results Posted
33%(2 trials)
Terminated
1(8%)

Phase Distribution

Ph phase_2
1
8%
Ph phase_1
8
62%
Ph phase_3
2
15%

Phase Distribution

8

Early Stage

1

Mid Stage

2

Late Stage

Phase Distribution11 total trials
Phase 1Safety & dosage
8(72.7%)
Phase 2Efficacy & side effects
1(9.1%)
Phase 3Large-scale testing
2(18.2%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

75.0%

6 of 8 finished

Non-Completion Rate

25.0%

2 ended early

Currently Active

5

trials recruiting

Total Trials

13

all time

Status Distribution
Active(5)
Completed(6)
Terminated(2)

Detailed Status

Completed6
Recruiting3
Active, not recruiting2
Withdrawn1
Terminated1

Development Timeline

Analytics

Development Status

Total Trials
13
Active
5
Success Rate
85.7%
Most Advanced
Phase 3

Trials by Phase

Phase 18 (72.7%)
Phase 21 (9.1%)
Phase 32 (18.2%)

Trials by Status

withdrawn18%
completed646%
terminated18%
recruiting323%
active_not_recruiting215%

Recent Activity

Clinical Trials (13)

Showing 13 of 13 trials
NCT04282187Phase 2

Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms

Recruiting
NCT04446650Phase 1

A Study of Fedratinib in Japanese Subjects With DIPSS (Dynamic International Prognostic Scoring System)- Intermediate or High-risk Primary Myelofibrosis (PMF), Post-polycythemia Vera Myelofibrosis (Post-PV MF), or Post-essential Thrombocythemia Myelofibrosis (Post-ET MF)

Active Not Recruiting
NCT04817007Phase 1

A Study to Assess the Safety and Tolerability of BMS-986158 Alone and in Combination With Either Ruxolitinib or Fedratinib in Participants With Blood Cancer (Myelofibrosis)

Active Not Recruiting
NCT03952039Phase 3

An Efficacy and Safety Study of Fedratinib Compared to Best Available Therapy in Subjects With DIPSS-intermediate or High-risk Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, or Post-essential Thrombocythemia Myelofibrosis and Previously Treated With Ruxolitinib

Completed
NCT03755518Phase 3

A Trial of Fedratinib in Subjects With DIPSS, Intermediate or High-Risk Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis and Previously Treated With Ruxolitinib

Terminated
NCT06073847

A Post-Marketing Surveillance Study to Assess the Safety of Fedratinib in Korean Patients With Myelofibrosis

Recruiting
NCT04955938Phase 1

A Study of Fedratinib With IDH Inhibition in Advanced-Phase, IDH-Mutated Ph-Negative Myeloproliferative Neoplasms

Withdrawn
NCT05883904

Real World Evidence of Fedratinib Effectiveness in MF

Recruiting
NCT03983161Phase 1

A Pharmacokinetics and Tolerability Study of Fedratinib in Subjects With Moderate and Severe Hepatic Impairment

Completed
NCT05051553Phase 1

A Study to Evaluate the Bioavailability of Fedratinib When Administered in Different Ways to Healthy Adult Participants

Completed
NCT04702464Phase 1

A Study to Evaluate the Effect of a Dual CYP2C19 and CYP3A4 Inhibitor, Fluconazole, on the Pharmacokinetics of Fedratinib in Healthy Adult Subjects

Completed
NCT03983239Phase 1

Effect of Rifampin and Efavirenz on the Pharmacokinetics of Fedratinib in Healthy Adult Subjects

Completed
NCT04231435Phase 1

Influence of Fedratinib on the Pharmacokinetics of the Transporter Probe Substrates Digoxin, Rosuvastatin, and Metformin

Completed

All 13 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
13