Success Metrics

Clinical Success Rate
85.7%

Based on 6 completed trials

Completion Rate
86%(6/7)
Active Trials
5(36%)
Results Posted
33%(2 trials)
Terminated
1(7%)

Phase Distribution

Ph phase_1
9
64%
Ph phase_2
1
7%
Ph phase_3
2
14%

Phase Distribution

9

Early Stage

1

Mid Stage

2

Late Stage

Phase Distribution12 total trials
Phase 1Safety & dosage
9(75.0%)
Phase 2Efficacy & side effects
1(8.3%)
Phase 3Large-scale testing
2(16.7%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

75.0%

6 of 8 finished

Non-Completion Rate

25.0%

2 ended early

Currently Active

5

trials recruiting

Total Trials

14

all time

Status Distribution
Active(6)
Completed(6)
Terminated(2)

Detailed Status

Completed6
Recruiting3
Active, not recruiting2
Not yet recruiting1
Withdrawn1
Terminated1

Development Timeline

Analytics

Development Status

Total Trials
14
Active
5
Success Rate
85.7%
Most Advanced
Phase 3

Trials by Phase

Phase 19 (75.0%)
Phase 21 (8.3%)
Phase 32 (16.7%)

Trials by Status

completed643%
not_yet_recruiting17%
recruiting321%
withdrawn17%
active_not_recruiting214%
terminated17%

Recent Activity

Clinical Trials (14)

Showing 14 of 14 trials
NCT07734077Phase 1

Revumenib in Patients With Myelofibrosis

Not Yet Recruiting
NCT04817007Phase 1

A Study to Assess the Safety and Tolerability of BMS-986158 Alone and in Combination With Either Ruxolitinib or Fedratinib in Participants With Blood Cancer (Myelofibrosis)

Active Not Recruiting
NCT04282187Phase 2

Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms

Recruiting
NCT04446650Phase 1

A Study of Fedratinib in Japanese Subjects With DIPSS (Dynamic International Prognostic Scoring System)- Intermediate or High-risk Primary Myelofibrosis (PMF), Post-polycythemia Vera Myelofibrosis (Post-PV MF), or Post-essential Thrombocythemia Myelofibrosis (Post-ET MF)

Active Not Recruiting
NCT03952039Phase 3

An Efficacy and Safety Study of Fedratinib Compared to Best Available Therapy in Subjects With DIPSS-intermediate or High-risk Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, or Post-essential Thrombocythemia Myelofibrosis and Previously Treated With Ruxolitinib

Completed
NCT03755518Phase 3

A Trial of Fedratinib in Subjects With DIPSS, Intermediate or High-Risk Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis and Previously Treated With Ruxolitinib

Terminated
NCT06073847

A Post-Marketing Surveillance Study to Assess the Safety of Fedratinib in Korean Patients With Myelofibrosis

Recruiting
NCT04955938Phase 1

A Study of Fedratinib With IDH Inhibition in Advanced-Phase, IDH-Mutated Ph-Negative Myeloproliferative Neoplasms

Withdrawn
NCT05883904

Real World Evidence of Fedratinib Effectiveness in MF

Recruiting
NCT03983161Phase 1

A Pharmacokinetics and Tolerability Study of Fedratinib in Subjects With Moderate and Severe Hepatic Impairment

Completed
NCT05051553Phase 1

A Study to Evaluate the Bioavailability of Fedratinib When Administered in Different Ways to Healthy Adult Participants

Completed
NCT04702464Phase 1

A Study to Evaluate the Effect of a Dual CYP2C19 and CYP3A4 Inhibitor, Fluconazole, on the Pharmacokinetics of Fedratinib in Healthy Adult Subjects

Completed
NCT03983239Phase 1

Effect of Rifampin and Efavirenz on the Pharmacokinetics of Fedratinib in Healthy Adult Subjects

Completed
NCT04231435Phase 1

Influence of Fedratinib on the Pharmacokinetics of the Transporter Probe Substrates Digoxin, Rosuvastatin, and Metformin

Completed

All 14 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
14