Success Metrics

Clinical Success Rate
85.7%

Based on 6 completed trials

Completion Rate
86%(6/7)
Active Trials
10(56%)
Results Posted
83%(5 trials)
Terminated
1(6%)

Phase Distribution

Ph phase_2
1
6%
Ph phase_3
1
6%
Ph early_phase_1
1
6%
Ph phase_1
15
83%

Phase Distribution

16

Early Stage

1

Mid Stage

1

Late Stage

Phase Distribution18 total trials
Early Phase 1First-in-human
1(5.6%)
Phase 1Safety & dosage
15(83.3%)
Phase 2Efficacy & side effects
1(5.6%)
Phase 3Large-scale testing
1(5.6%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

75.0%

6 of 8 finished

Non-Completion Rate

25.0%

2 ended early

Currently Active

10

trials recruiting

Total Trials

18

all time

Status Distribution
Active(10)
Completed(6)
Terminated(2)

Detailed Status

Active, not recruiting7
Completed6
Recruiting3
Withdrawn1
Terminated1

Development Timeline

Analytics

Development Status

Total Trials
18
Active
10
Success Rate
85.7%
Most Advanced
Phase 3

Trials by Phase

Early Phase 11 (5.6%)
Phase 115 (83.3%)
Phase 21 (5.6%)
Phase 31 (5.6%)

Trials by Status

completed633%
recruiting317%
withdrawn16%
active_not_recruiting739%
terminated16%

Recent Activity

Clinical Trials (18)

Showing 18 of 18 trials
NCT05249426Phase 1

A Study to Test Whether Different Combinations of BI 765063, Ezabenlimab, Chemotherapy, Cetuximab, and BI 836880 Help People With Head and Neck Cancer or Liver Cancer

Active Not Recruiting
NCT04958239Phase 1

A Study to Test BI 765179 Alone and in Combination With Ezabenlimab in Patients With Advanced Cancer (Solid Tumors) and BI 765179 in Combination With Pembrolizumab in Patients With Advanced Head and Neck Cancer

Active Not Recruiting
NCT05879978Phase 1

A Study to Test How Well Different Doses of Obrixtamig (BI 764532) in Combination With Ezabenlimab Are Tolerated by People With Small Cell Lung Cancer and Other Neuroendocrine Tumours That Are Positive for DLL3

Active Not Recruiting
NCT03383978Phase 1

Intracranial Injection of NK-92/5.28.z Cells in Combination With Intravenous Ezabenlimab in Patients With Recurrent HER2-positive Glioblastoma

Recruiting
NCT05068102Phase 1

A Study to Test How BI 765063 and BI 770371 Are Taken up in Tumours of People With Different Types of Advanced Cancer Who Are Also Taking Ezabenlimab

Active Not Recruiting
NCT07395258Phase 1

A Study to Test Different Doses of BI 3923948 Alone and in Combination With an Anti-PD-1 Antibody in People With Different Types of Advanced Cancer (Solid Tumors)

Recruiting
NCT06091930Phase 1

A Study to Test Different Doses of BI 765049 Alone and in Combination With Ezabenlimab in Asian People With Advanced Cancer (Solid Tumours) Positive for B7-H6

Active Not Recruiting
NCT05846516Phase 1

A Study to Test KISIMA-02 Vaccine-based Immunotherapy and Ezabenlimab in People With Pancreatic Cancer

Active Not Recruiting
NCT03964233Phase 1

A Study in Patients With Different Types of Advanced Cancer (Solid Tumors) to Test Different Doses of BI 907828 (Brigimadlin) in Combination With BI 754091 (Ezabenlimab) and BI 754111 or BI 907828 (Brigimadlin) in Combination With BI 754091 (Ezabenlimab)

Completed
NCT04752215Phase 1

A Study Evaluating Different Doses of BI 765049 When Given Alone and When Given With Ezabenlimab to Patients With Advanced Solid Tumors Expressing the Protein B7-H6 on the Cell Surface

Completed
NCT03697304Phase 2

Platform Trial Evaluating Safety and Efficacy of Ezabenlimab Anti- PD-1 Based Combination Therapies in PD-(L)1 naïve and PD- (L)1 Pretreated Patient Populations With Advanced/Metastatic Solid Tumours

Completed
NCT03156114Phase 1

This Study Tests the New Medicine BI 754111 Alone or in Combination With Another New Substance BI 754091 in Patients With Advanced Cancer. The Study Tests Different Doses to Find the Best Dose for Continuous Treatment.

Completed
NCT03433898Early Phase 1

This Study Aims to Find a Safe and Effective Dose of BI 754091. The Study Also Aims to Find Safe and Effective Doses of BI 754091 and BI 754111 in Combination. This Study is Done in Asian Patients With Different Types of Cancer

Completed
NCT05471856Phase 1

A Study to Test How Different Doses of BI 1703880 in Combination With Ezabenlimab Are Tolerated in People With Different Types of Advanced Cancer (Solid Tumours)

Recruiting
NCT03468426Phase 1

A Study to Test Different Doses of BI 836880 Combined With Ezabenlimab in Patients With Advanced Non-small Cell Lung Cancer Followed by Other Types of Advanced Solid Tumours

Completed
NCT05327946Phase 1

A Study in People With Advanced Cancer to Test How Well Different Doses of BI 770371 Alone or in Combination With Ezabenlimab Are Tolerated

Active Not Recruiting
NCT05446129Phase 1

A Study in People With Colorectal Cancer to Test Whether Ezabenlimab or Pembrolizumab in Combination With BI 765063 Lead to Side Effects or Delays in Surgery

Terminated
NCT06370871Phase 3

Brightline-3: A Study to Find Out Whether Brigimadlin in Combination With Ezabenlimab Helps People With Advanced Soft Tissue Sarcoma

Withdrawn

All 18 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
18