Success Metrics

Clinical Success Rate
66.7%

Based on 8 completed trials

Completion Rate
67%(8/12)
Active Trials
13(46%)
Results Posted
138%(11 trials)
Terminated
4(14%)

Phase Distribution

Ph not_applicable
1
4%
Ph phase_2
16
57%
Ph phase_1
8
29%
Ph phase_3
1
4%
Ph early_phase_1
1
4%

Phase Distribution

9

Early Stage

16

Mid Stage

1

Late Stage

Phase Distribution27 total trials
Early Phase 1First-in-human
1(3.7%)
Phase 1Safety & dosage
8(29.6%)
Phase 2Efficacy & side effects
16(59.3%)
Phase 3Large-scale testing
1(3.7%)
N/ANon-phased studies
1(3.7%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

61.5%

8 of 13 finished

Non-Completion Rate

38.5%

5 ended early

Currently Active

13

trials recruiting

Total Trials

28

all time

Status Distribution
Active(13)
Completed(8)
Terminated(5)
Other(2)

Detailed Status

Active, not recruiting11
Completed8
Terminated4
Recruiting2
unknown2
Withdrawn1

Development Timeline

Analytics

Development Status

Total Trials
28
Active
13
Success Rate
66.7%
Most Advanced
Phase 3

Trials by Phase

Early Phase 11 (3.7%)
Phase 18 (29.6%)
Phase 216 (59.3%)
Phase 31 (3.7%)
N/A1 (3.7%)

Trials by Status

withdrawn14%
active_not_recruiting1139%
recruiting27%
terminated414%
unknown27%
completed829%

Recent Activity

Clinical Trials (28)

Showing 20 of 28 trialsScroll for more
NCT06351371Phase 2

Testing JNJ-42756493 (Erdafitinib) as Potentially Targeting Treatment in Cancers With FGFR Mutations or Fusions (MATCH - Subprotocol K2)

Active Not Recruiting
NCT03155620Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

Active Not Recruiting
NCT02365597Phase 2

An Efficacy and Safety Study of Erdafitinib (JNJ-42756493) in Participants With Urothelial Cancer

Active Not Recruiting
NCT04963153Phase 1

Testing Combination Erdafitinib and Enfortumab Vedotin in Metastatic Bladder Cancer After Treatment With Chemotherapy and Immunotherapy

Active Not Recruiting
NCT02465060Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

Active Not Recruiting
NCT03390504Phase 3

A Study of Erdafitinib Compared With Vinflunine or Docetaxel or Pembrolizumab in Participants With Advanced Urothelial Cancer and Selected Fibroblast Growth Factor Receptor (FGFR) Gene Aberrations

Active Not Recruiting
NCT06308822Phase 2

Testing JNJ-42756493 (Erdafitinib) as Potentially Targeting Treatment in Cancers With FGFR Amplifications (MATCH-Subprotocol K1)

Active Not Recruiting
NCT05859334Phase 2

Testing the Anti-cancer Drug Erdafitinib for Brain Cancers That Have Returned or Progressed Following Treatment

Recruiting
NCT03210714Phase 2

Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial)

Active Not Recruiting
NCT03473743Phase 1

A Study of Erdafitinib in Participants With Metastatic or Locally Advanced Urothelial Cancer

Active Not Recruiting
NCT04083976Phase 2

A Study of Erdafitinib in Participants With Advanced Solid Tumors and Fibroblast Growth Factor Receptor (FGFR) Gene Alterations

Active Not Recruiting
NCT04172675Phase 2

A Study of Erdafitinib Versus Investigator Choice of Intravesical Chemotherapy in Participants Who Received Bacillus Calmette-Guérin (BCG) and Recurred With High Risk Non-Muscle-Invasive Bladder Cancer (NMIBC)

Completed
NCT04754425Phase 2

Erdafitinib for the Treatment of Patients With Castration-Resistant Prostate Cancer

Terminated
NCT05564416Phase 2

Testing Anti-Cancer Drugs Erdafitinib With or Without Atezolizumab in Patients With Localized Bladder Cancer Not Able to Receive Cisplatin Chemotherapy, NERA Trial

Withdrawn
NCT04917809Phase 2

A Study of Oral Erdafitinib in People With Recurrent Non-Invasive Bladder Cancer

Active Not Recruiting
NCT03825484

Expanded Access Program (EAP) for Participants With Advanced Cancers and Fibroblast Growth Factor Receptor (FGFR) Genetic Alterations Who Have Exhausted All Treatment Options

Unknown
NCT03547037Phase 1

A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of JNJ-63723283, an Anti-Programmed Cell Death (PD)-1 Monoclonal Antibody, as Monotherapy or in Combination With Erdafitinib in Japanese Participants With Advanced Solid Cancers

Completed
NCT02699606Phase 2

A Study to Evaluate the Clinical Efficacy of JNJ-42756493 (Erdafitinib), A Pan-Fibroblast Growth Factor Receptor (FGFR) Tyrosine Kinase Inhibitor, In Asian Participants With Advanced Non-Small-Cell Lung Cancer, Urothelial Cancer, Esophageal Cancer Or Cholangiocarcinoma

Completed
NCT03135106Phase 1

A Study to Evaluate the Effect of Fluconazole and Itraconazole on Erdafitinib Pharmacokinetics in Healthy Adult Participants

Completed
NCT03587363Phase 1

A Study to Evaluate the Effect of Hepatic Impairment on the Pharmacokinetics of Erdafitinib

Terminated

Drug Details

Intervention Type
DRUG
Total Trials
28