Success Metrics

Clinical Success Rate
66.7%

Based on 6 completed trials

Completion Rate
67%(6/9)
Active Trials
19(58%)
Results Posted
100%(6 trials)
Terminated
3(9%)

Phase Distribution

Ph phase_2
17
52%
Ph early_phase_1
1
3%
Ph phase_1
7
21%
Ph phase_3
3
9%

Phase Distribution

8

Early Stage

17

Mid Stage

3

Late Stage

Phase Distribution28 total trials
Early Phase 1First-in-human
1(3.6%)
Phase 1Safety & dosage
7(25.0%)
Phase 2Efficacy & side effects
17(60.7%)
Phase 3Large-scale testing
3(10.7%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

60.0%

6 of 10 finished

Non-Completion Rate

40.0%

4 ended early

Currently Active

19

trials recruiting

Total Trials

33

all time

Status Distribution
Active(21)
Completed(6)
Terminated(4)
Other(2)

Detailed Status

Recruiting10
Active, not recruiting9
Completed6
Terminated3
unknown2
Not yet recruiting2

Development Timeline

Analytics

Development Status

Total Trials
33
Active
19
Success Rate
66.7%
Most Advanced
Phase 3

Trials by Phase

Early Phase 11 (3.6%)
Phase 17 (25.0%)
Phase 217 (60.7%)
Phase 33 (10.7%)

Trials by Status

active_not_recruiting927%
terminated39%
unknown26%
completed618%
withdrawn13%
recruiting1030%
not_yet_recruiting26%

Recent Activity

Clinical Trials (33)

Showing 20 of 33 trialsScroll for more
NCT05170204Phase 3

A Study Evaluating the Efficacy and Safety of Multiple Therapies in Cohorts of Participants With Locally Advanced, Unresectable, Stage III Non-Small Cell Lung Cancer (NSCLC)

Active Not Recruiting
NCT05396859Phase 1

Entrectinib in Combination With ASTX727 for the Treatment of Relapsed/Refractory TP53 Mutated Acute Myeloid Leukemia

Active Not Recruiting
NCT06528691Phase 2

Entrectinib as a Single Agent in Upfront Therapy for Children <3 Years of Age With NTRK1/2/3 or ROS1-FUSED CNS Tumors

Recruiting
NCT03994796Phase 2

Genetic Testing in Guiding Treatment for Patients With Brain Metastases

Active Not Recruiting
NCT05862285Phase 3

A Rollover Study for Participants Previously Enrolled in a Genentech and/or F. Hoffman-La Roche Sponsored Study

Recruiting
NCT04589845Phase 2

Tumor-agnostic Precision Immuno-oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study

Active Not Recruiting
NCT02650401Phase 1

Study Of Entrectinib (Rxdx-101) in Children and Adolescents With Locally Advanced Or Metastatic Solid Or Primary CNS Tumors And/Or Who Have No Satisfactory Treatment Options

Active Not Recruiting
NCT03178552Phase 2

A Study to Evaluate the Efficacy and Safety of Multiple Targeted Therapies as Treatments for Participants With Non-Small Cell Lung Cancer (NSCLC)

Active Not Recruiting
NCT04302025Phase 2

A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)

Recruiting
NCT02568267Phase 2

Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)

Active Not Recruiting
NCT04603807Phase 3

A Study to Compare the Efficacy and Safety of Entrectinib and Crizotinib in Participants With Advanced or Metastatic ROS1 Non-small Cell Lung Cancer (NSCLC) With and Without Central Nervous System (CNS) Metastases

Active Not Recruiting
NCT05722886Phase 2

DETERMINE (Determining Extended Therapeutic Indications for Existing Drugs in Rare Molecularly Defined Indications Using a National Evaluation Platform Trial) - Master Screening Protocol

Recruiting
NCT05770544Phase 2

DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Paediatric and Teenage/Young Adult Patients With ROS1 Gene Fusion-Positive Cancers.

Recruiting
NCT03498521Phase 2

A Phase II Randomized Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Versus Platinum-Based Chemotherapy in Patients With Cancer of Unknown Primary Site

Completed
NCT07199959

Study on the Mechanism of Acquired Resistance of Entrectinib

Recruiting
NCT05525858

KPMNG Study of MOlecular Profiling Guided Therapy Based on Genomic Alterations in Advanced Solid Tumors II

Recruiting
NCT05834348

A Study to Learn About the Effectiveness of Cancer Medicines in Patients With Metastatic Non-small Cell Lung Cancer in Norway.

Completed
NCT04632992Phase 2

A Study Evaluating Targeted Therapies in Participants Who Have Advanced Solid Tumors With Genomic Alterations or Protein Expression Patterns Predictive of Response

Completed
NCT06482086Phase 2

Efficacy of Organoid-Based Drug Screening to Guide Treatment for Locally Advanced Thyroid Cancer

Recruiting
NCT04551495Phase 2

Neoadjuvant Study of Targeting ROS1 in Combination With Endocrine Therapy in Invasive Lobular Carcinoma of the Breast (ROSALINE)

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
33