Success Metrics

Clinical Success Rate
86.7%

Based on 13 completed trials

Completion Rate
87%(13/15)
Active Trials
21(45%)
Results Posted
31%(4 trials)
Terminated
2(4%)

Phase Distribution

Ph phase_4
1
2%
Ph not_applicable
4
9%
Ph phase_2
20
43%
Ph phase_3
12
26%
Ph phase_1
3
6%

Phase Distribution

3

Early Stage

20

Mid Stage

13

Late Stage

Phase Distribution40 total trials
Phase 1Safety & dosage
3(7.5%)
Phase 2Efficacy & side effects
20(50.0%)
Phase 3Large-scale testing
12(30.0%)
Phase 4Post-market surveillance
1(2.5%)
N/ANon-phased studies
4(10.0%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

72.2%

13 of 18 finished

Non-Completion Rate

27.8%

5 ended early

Currently Active

21

trials recruiting

Total Trials

47

all time

Status Distribution
Active(23)
Completed(13)
Terminated(5)
Other(6)

Detailed Status

Recruiting13
Completed13
Active, not recruiting8
unknown6
Withdrawn3
Terminated2

Development Timeline

Analytics

Development Status

Total Trials
47
Active
21
Success Rate
86.7%
Most Advanced
Phase 4

Trials by Phase

Phase 13 (7.5%)
Phase 220 (50.0%)
Phase 312 (30.0%)
Phase 41 (2.5%)
N/A4 (10.0%)

Trials by Status

withdrawn36%
terminated24%
recruiting1328%
unknown613%
completed1328%
not_yet_recruiting24%
active_not_recruiting817%

Recent Activity

Clinical Trials (47)

Showing 20 of 47 trialsScroll for more
NCT06195709Phase 3

ECLECTIC: EstroTEP and Circulating Biomarkers for ER-positive HER2-negative Metastatic Breast Cancer Patients

Recruiting
NCT05399329

Study to Evaluate Real-world Effectiveness With Palbociclib Plus Endocrine Therapy as First-line/Second-line Treatment for HR+/HER2- Advanced Breast Cancer in Japan

Completed
NCT03573648Phase 2

Neoadjuvant Endocrine Therapy, Palbociclib, Avelumab in Estrogen Receptor Positive Breast Cancer

Active Not Recruiting
NCT04923542Phase 1

Stereotactic Radiation & Abemaciclib in the Management of HR+/HER2- Breast Cancer Brain Metastases

Recruiting
NCT02057133Phase 1

A Study of LY2835219 (Abemaciclib) in Combination With Therapies for Breast Cancer That Has Spread

Active Not Recruiting
NCT03285412Phase 2

CDK 4/6 Inhibitor, Ribociclib, With Adjuvant Endocrine Therapy for ER-positive Breast Cancer

Active Not Recruiting
NCT02352883Not Applicable

MRI and Gene Expression in Diagnosing Patients With Ductal Breast Cancer In Situ

Active Not Recruiting
NCT06369285Phase 2

A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer

Recruiting
NCT04921137Phase 4

Evaluating Harms and Benefits of Endocrine Therapy in Patients ≥70 Years of Age With Lower Risk Breast Cancer

Active Not Recruiting
NCT05919108Phase 2

Neoadjuvant Neratinib in Stage I-III HER2-Mutated Lobular Breast Cancers

Recruiting
NCT06914440Phase 2

Neoadjuvant SBRT Followed by Nab-Paclitaxel Combined With Toripalimab in HR+/HER2- Breast Cancer

Recruiting
NCT03725059Phase 3

Study of Pembrolizumab (MK-3475) Versus Placebo in Combination With Neoadjuvant Chemotherapy & Adjuvant Endocrine Therapy in the Treatment of Early-Stage Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer (MK-3475-756/KEYNOTE-756)

Active Not Recruiting
NCT07005557Phase 3

Chemo-free in Older (≥65) Node-Positive ER+/HER2- Breast Cancer

Not Yet Recruiting
NCT02764541Phase 2

Palbociclib and Endocrine Therapy for LObular Breast Cancer Preoperative Study (PELOPS)

Active Not Recruiting
NCT05306041Phase 2

Neoadjuvant Endocrine Therapy +/- the PI3K Inhibitor Inavolisib in HER2+, HR+, PIK3CA Mutant Early Breast Cancer

Recruiting
NCT04109066Phase 3

Study of Nivolumab Versus Placebo in Combination With Neoadjuvant Chemotherapy and Adjuvant Endocrine Therapy in Participants With High-risk, Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor 2-Negative (HER2-) Primary Breast Cancer

Completed
NCT01897441Not Applicable

Chemotherapy Before Surgery and Tissue Sample Collection in Patients With Stage IIA-IIIC Breast Cancer

Terminated
NCT06044623Phase 3

Implementing Geriatric Assessment for Dose Optimization of Cyclin-dependent Kinase (CDK) 4/6-inhibitors in Older Breast Cancer Patients

Recruiting
NCT06637150Phase 3

Dalpicilib-Enhanced Vs. Standard Endocrine Therapy in ER+ HER2- Early Breast Cancer

Active Not Recruiting
NCT06548919

Current Status of Treatment for Chinese Patients With ESR1-mutated HR+/HER2-advanced Breast Cancer

Recruiting

Drug Details

Intervention Type
COMBINATION PRODUCT
Total Trials
47