Success Metrics

Clinical Success Rate
53.8%

Based on 14 completed trials

Completion Rate
54%(14/26)
Active Trials
25(46%)
Results Posted
107%(15 trials)
Terminated
12(22%)

Phase Distribution

Ph phase_3
4
7%
Ph phase_1
19
35%
Ph early_phase_1
2
4%
Ph not_applicable
1
2%
Ph phase_2
25
46%

Phase Distribution

21

Early Stage

25

Mid Stage

4

Late Stage

Phase Distribution51 total trials
Early Phase 1First-in-human
2(3.9%)
Phase 1Safety & dosage
19(37.3%)
Phase 2Efficacy & side effects
25(49.0%)
Phase 3Large-scale testing
4(7.8%)
N/ANon-phased studies
1(2.0%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

53.8%

14 of 26 finished

Non-Completion Rate

46.2%

12 ended early

Currently Active

25

trials recruiting

Total Trials

54

all time

Status Distribution
Active(26)
Completed(14)
Terminated(12)
Other(2)

Detailed Status

Completed14
Recruiting13
Terminated12
Active, not recruiting12
unknown2
Not yet recruiting1

Development Timeline

Analytics

Development Status

Total Trials
54
Active
25
Success Rate
53.8%
Most Advanced
Phase 3

Trials by Phase

Early Phase 12 (3.9%)
Phase 119 (37.3%)
Phase 225 (49.0%)
Phase 34 (7.8%)
N/A1 (2.0%)

Trials by Status

unknown24%
not_yet_recruiting12%
terminated1222%
active_not_recruiting1222%
recruiting1324%
completed1426%

Recent Activity

Clinical Trials (54)

Showing 20 of 54 trialsScroll for more
NCT06102902Phase 1

Testing the Addition of Anti-cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment, Cetuximab Plus Encorafenib, for Colorectal Cancer

Recruiting
NCT05195632Phase 2

Phase II Study Investigating the Combination of Encorafenib and Binimetinib in BRAF V600E Mutated Chinese Patients With Metastatic Non-Small Cell Lung Cancer

Active Not Recruiting
NCT05004350Phase 2

A Study Evaluating the Combination of Encorafenib and Cetuximab Versus Irinotecan/Cetuximab or Infusional 5-fluorouracil (5-FU)/Folinic Acid (FA)/Irinotecan (FOLFIRI)/Cetuximab in Chinese Patients With BRAF V600E Mutant Metastatic Colorectal Cancer.

Completed
NCT05308446Phase 2

Testing the Addition of Nivolumab to Standard Treatment for Patients With Metastatic or Unresectable Colorectal Cancer That Have a BRAF Mutation

Active Not Recruiting
NCT05026983Phase 2

Binimetinib and Encorafenib for the Treatment of Metastatic Melanoma and Central Nervous System Metastases

Recruiting
NCT04061980Phase 2

Encorafenib and Binimetinib With or Without Nivolumab in Treating Patients With Metastatic Radioiodine Refractory BRAF V600 Mutant Thyroid Cancer

Active Not Recruiting
NCT04221438Phase 2

Testing Treatment With Encorafenib and Binimetinib Before Surgery for Melanoma With Lymph Node Involvement

Terminated
NCT04324112Phase 2

Encorafenib Plus Binimetinib for People With BRAF V600 Mutated Relapsed/Refractory HCL

Recruiting
NCT05039177Phase 1

A Study of ERAS-007 in Patients With Advanced Gastrointestinal Malignancies

Completed
NCT03915951Phase 2

An Open-label Study of Encorafenib + Binimetinib in Patients With BRAFV600-mutant Non-small Cell Lung Cancer

Completed
NCT05217446Phase 2

A Study of Encorafenib Plus Cetuximab Taken Together With Pembrolizumab Compared to Pembrolizumab Alone in People With Previously Untreated Metastatic Colorectal Cancer

Active Not Recruiting
NCT05985954Phase 1

Open-label Phase 1b Study of Ulixertinib and Cetuximab or Ulixertinib in Combination With Cetuximab and Encorafenib in Patients With Unresectable or Metastatic Colorectal Cancer Who Have Previously Received EGFR or BRAF-directed Therapy

Recruiting
NCT05926960Phase 2

A Study Comparing 3 Study Medicines (Encorafenib, Binimetinib, Pembrolizumab) to 2 Study Medicines (Ipilimumab and Nivolumab) in Patients With Advanced Melanoma

Terminated
NCT04657991Phase 3

A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma

Active Not Recruiting
NCT07318389Early Phase 1

ASCEND-CRC: Profiling and Targeting Dynamic Tumor Resistance in Patients With Metastatic Colorectal Cancer

Not Yet Recruiting
NCT04903119Phase 1

Nilotinib Plus Dabrafenib/Trametinib or Encorafenib/Binimetinib in Metastatic Melanoma

Recruiting
NCT03543969Early Phase 1

Adaptive BRAF-MEK Inhibitor Therapy for Advanced BRAF Mutant Melanoma

Active Not Recruiting
NCT05710406Phase 2

Testing the Use of BRAF-Targeted Therapy After Surgery and Usual Chemotherapy for BRAF-Mutated Colon Cancer

Active Not Recruiting
NCT04585815Phase 1

Study of Immunotherapy (Sasanlimab) in Combination With Targeted Therapies in People With Advanced Non-small Cell Lung Cancer (NSCLC) (Landscape 1011 Study)

Terminated
NCT06578559Phase 2

Phase II Study of ctDNA-guided Encorafenib Plus Cetuximab Retreatment in Patients BRAF V600E Mutated mCRC

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
54