Success Metrics

Clinical Success Rate
93.5%

Based on 43 completed trials

Completion Rate
93%(43/46)
Active Trials
5(8%)
Results Posted
42%(18 trials)
Terminated
3(5%)

Phase Distribution

Ph early_phase_1
1
2%
Ph phase_3
21
32%
Ph not_applicable
7
11%
Ph phase_4
20
30%
Ph phase_1
5
8%
Ph phase_2
11
17%

Phase Distribution

6

Early Stage

11

Mid Stage

41

Late Stage

Phase Distribution65 total trials
Early Phase 1First-in-human
1(1.5%)
Phase 1Safety & dosage
5(7.7%)
Phase 2Efficacy & side effects
11(16.9%)
Phase 3Large-scale testing
21(32.3%)
Phase 4Post-market surveillance
20(30.8%)
N/ANon-phased studies
7(10.8%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

91.5%

43 of 47 finished

Non-Completion Rate

8.5%

4 ended early

Currently Active

5

trials recruiting

Total Trials

66

all time

Status Distribution
Active(8)
Completed(43)
Terminated(4)
Other(11)

Detailed Status

Completed43
unknown11
Recruiting4
Terminated3
Not yet recruiting2
Enrolling by invitation1

Development Timeline

Analytics

Development Status

Total Trials
66
Active
5
Success Rate
93.5%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (1.5%)
Phase 15 (7.7%)
Phase 211 (16.9%)
Phase 321 (32.3%)
Phase 420 (30.8%)
N/A7 (10.8%)

Trials by Status

enrolling_by_invitation12%
withdrawn12%
active_not_recruiting12%
completed4365%
not_yet_recruiting23%
recruiting46%
terminated35%
unknown1117%

Recent Activity

Clinical Trials (66)

Showing 20 of 66 trialsScroll for more
NCT07568574Not Applicable

Impact of Medically Supervised Performance-Enhancing Substances (PES) on Elite Athletes

Enrolling By Invitation
NCT07547878Phase 4

Simultaneous Starting of the 4 Guideline Directed CKD Therapies (RAPID-CKD)

Active Not Recruiting
NCT03051282Phase 4

Genetic Determinants of ACEI Prodrug Activation

Completed
NCT04023227Phase 4

Efficacy and Safety of Sacubitril/Valsartan Compared With Enalapril on Morbidity, Mortality, and NT-proBNP Change in Patients With CCC

Completed
NCT07222852Phase 3

Cardiovascular Protection After Preeclampsia With Enalapril

Not Yet Recruiting
NCT04183101Phase 2

Evaluation of a Renin Inhibitor, Aliskiren, Compared to Enalapril, in C3 Glomerulopathy

Recruiting
NCT03460366

Bariatric Surgery and Pharmacokinetics of Enalapril

Recruiting
NCT06788314Phase 2

A Study of Enalapril in Treatment of Venous Malformations

Recruiting
NCT04853758Phase 3

Angiotensin Receptor-Neprilysin Inhibition in Chagas Cardiomyopathy With Reduced Ejection Fraction: ANSWER-HF.

Recruiting
NCT03917459Phase 3

COmparing arNi and Ace For Improving Erectile Dysfunction in mEN With reduCed Ejection Fraction Heart Failure

Completed
NCT03265574Phase 3

PROACT: Can we Prevent Chemotherapy-related Heart Damage in Patients With Breast Cancer and Lymphoma?

Completed
NCT02468232Phase 3

Study of Efficacy and Safety of LCZ696 in Japanese Patients With Chronic Heart Failure and Reduced Ejection Fraction

Completed
NCT04484350Phase 2

Blood Pressure Management in Stroke Following Endovascular Treatment

Completed
NCT01968200Phase 3

Prevention of Anthracycline-induced Cardiotoxicity

Unknown
NCT05487261Phase 4

Pulmonary REsistance Modification Under Treatment With Sacubitril/valsartaN in paTients With Heart Failure With Reduced Ejection Fraction

Unknown
NCT02678312Phase 2

Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LCZ696 Followed by a 52-week, Double-blind Study of LCZ696 Compared With Enalapril in Pediatric Patients With Heart Failure

Completed
NCT04236258Phase 4

Comparing Nifedipine and Enalapril in Medical Resources Used in the Postpartum Period

Completed
NCT03066804Phase 3

A Randomized, Double-blind Controlled Study Comparing LCZ696 to Medical Therapy for Comorbidities in HFpEF Patients

Completed
NCT02768298Phase 4

Exercise Capacity Study of LCZ696 vs. Enalapril in Patients With Chronic Heart Failure and Reduced Ejection Fraction.

Completed
NCT02970669Phase 4

Study on the Effects of Sacubitril/Valsartan on Physical Activity and Sleep in Heart Failure With Reduced Ejection Fraction Patients.

Completed

Drug Details

Intervention Type
DRUG
Total Trials
66