Success Metrics

Clinical Success Rate
63.6%

Based on 14 completed trials

Completion Rate
64%(14/22)
Active Trials
0(0%)
Results Posted
93%(13 trials)
Terminated
8(30%)

Phase Distribution

Ph phase_2
20
74%
Ph phase_1
6
22%
Ph phase_3
1
4%

Phase Distribution

6

Early Stage

20

Mid Stage

1

Late Stage

Phase Distribution27 total trials
Phase 1Safety & dosage
6(22.2%)
Phase 2Efficacy & side effects
20(74.1%)
Phase 3Large-scale testing
1(3.7%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

58.3%

14 of 24 finished

Non-Completion Rate

41.7%

10 ended early

Currently Active

0

trials recruiting

Total Trials

27

all time

Status Distribution
Completed(14)
Terminated(10)
Other(3)

Detailed Status

Completed14
Terminated8
unknown3
Withdrawn2

Development Timeline

Analytics

Development Status

Total Trials
27
Active
0
Success Rate
63.6%
Most Advanced
Phase 3

Trials by Phase

Phase 16 (22.2%)
Phase 220 (74.1%)
Phase 31 (3.7%)

Trials by Status

terminated830%
unknown311%
withdrawn27%
completed1452%

Recent Activity

Clinical Trials (27)

Showing 20 of 27 trialsScroll for more
NCT01732107Phase 2

Dovitinib in BCG Refractory Urothelial Carcinoma With FGFR3 Mutations or Over-expression

Terminated
NCT01443481Phase 1

Pharmacokinetics (PK) of TKI258 in Cancer Patients With Normal and Impaired Hepatic Function

Completed
NCT01548924Phase 1

Determination of Dose of Antiangiogenic Multitargeted DOVITINIB (TKI258) Plus Paclitaxel in Patients With Solid Tumors

Terminated
NCT01635907Phase 2

Dovitinib in Neuroendocrine Tumors

Completed
NCT01440959Phase 2

Dovitinib for Imatinib/Sumitinib-failed Gastrointestinal Stromal Tumors (GIST): TKI258

Completed
NCT01719549Phase 2

Dovitinib for Gastric Cancer With FGFR2 Amplification: GASDOVI-1

Completed
NCT01262027Phase 2

TKI258 for Metastatic Inflammatory Breast Cancer Patients

Completed
NCT01994590Phase 2

Dovitinib (TKI258) and Abiraterone Acetate in Metastatic Castrate-Resistant Prostate Cancer (mCRPC)

Terminated
NCT02116803Phase 2

An Open Label Multi-center Extension Study to Evaluate Long-term Safety/ Tolerability of Dovitinib in Patients With Solid Tumors Who Continue to Receive Treatment With Dovitinib (TKI258) in Novartis-sponsored Single Agent Dovitinib Studies Which Fulfilled the Requirements for the Primary Objective

Completed
NCT01484041Phase 1

Dovitinib Plus an Aromatase Inhibitor for Metastatic Breast Cancer

Terminated
NCT01676714Phase 2

Study of Dovitinib and Biomarkers in Advanced Non-Small Cell Lung Cancer or Advanced Colorectal Cancer

Completed
NCT01753713Phase 2

Dovitinib in Treating Patients With Recurrent or Progressive Glioblastoma

Completed
NCT01514526Phase 2

Clinical Trial of Dovitinib in First-line Metastatic or Locally Advanced Non-resectable Adrenocortical Carcinoma

Completed
NCT01266070Phase 2

TKI 258 in Von Hippel-Lindau Syndrome (VHL)

Terminated
NCT01888965Phase 2

Maintenance Dovitinib for Colorectal and Pancreas Cancer

Terminated
NCT01528345Phase 2

Trial Evaluating Dovitinib Combined With Fulvestrant, in Postmenopausal Patients With HER2- and HR+ Breast Cancer

Terminated
NCT01972750Phase 1

Dovitinib (TKI258) in the Treatment of Patients With Relapsed Glioblastoma

Unknown
NCT01223027Phase 3

Study of Dovitinib Versus Sorafenib in Patients With Metastatic Renal Cell Carcinoma

Completed
NCT01232296Phase 2

A Study of Dovitinib Versus Sorafenib in Adult Patients With Hepatocellular Carcinoma (HCC) as a First Line Treatment

Completed
NCT01678105Phase 2

A Phase II Study of Dovitinib in Recurrent and/or Metastatic Adenoid Cystic Carcinoma of the Salivary Glands

Completed

Drug Details

Intervention Type
DRUG
Total Trials
27