Success Metrics

Clinical Success Rate
53.3%

Based on 8 completed trials

Completion Rate
53%(8/15)
Active Trials
49(65%)
Results Posted
188%(15 trials)
Terminated
7(9%)

Phase Distribution

Ph phase_2
42
56%
Ph phase_3
8
11%
Ph phase_4
1
1%
Ph phase_1
22
29%

Phase Distribution

22

Early Stage

42

Mid Stage

9

Late Stage

Phase Distribution73 total trials
Phase 1Safety & dosage
22(30.1%)
Phase 2Efficacy & side effects
42(57.5%)
Phase 3Large-scale testing
8(11.0%)
Phase 4Post-market surveillance
1(1.4%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

40.0%

8 of 20 finished

Non-Completion Rate

60.0%

12 ended early

Currently Active

49

trials recruiting

Total Trials

75

all time

Status Distribution
Active(53)
Completed(8)
Terminated(12)
Other(2)

Detailed Status

Active, not recruiting25
Recruiting24
Completed8
Terminated7
Withdrawn5
Not yet recruiting4

Development Timeline

Analytics

Development Status

Total Trials
75
Active
49
Success Rate
53.3%
Most Advanced
Phase 4

Trials by Phase

Phase 122 (30.1%)
Phase 242 (57.5%)
Phase 38 (11.0%)
Phase 41 (1.4%)

Trials by Status

not_yet_recruiting45%
completed811%
unknown23%
terminated79%
recruiting2432%
active_not_recruiting2533%
withdrawn57%

Recent Activity

Clinical Trials (75)

Showing 20 of 75 trialsScroll for more
NCT04313504Phase 2

Study Evaluating the Efficacy of Niraparib and Dostarlimab (TSR-042) in Recurrent/Metastatic HNSCC

Completed
NCT04126200Phase 1

Platform Study of Belantamab Mafodotin as Monotherapy and in Combination With Anti-cancer Treatments in Participants With Relapsed/Refractory Multiple Myeloma (RRMM)

Active Not Recruiting
NCT06023862Phase 2

A Three-arm Randomized Phase II Study of Dostarlimab Alone or With Bevacizumab Versus Nonplatinum Chemotherapy in Recurrent Gynecological Clear Cell Carcinoma: DOVE (APGOT-OV7/ ENGOT-ov80 Study)

Recruiting
NCT07408063Phase 2

A Comprehensive Multiomic Biomarker Evaluation Across Two Single-arm Cohorts to Elucidate Mechanisms of Response and Resistance in Recurrent/Metastatic (R/M) Head and Neck Squamous Cell Carcinoma (HNSCC)

Recruiting
NCT04701307Phase 2

Niraparib and Dostarlimab for the Treatment of Small Cell Lung Cancer and Other High-Grade Neuroendocrine Carcinomas

Active Not Recruiting
NCT06062420Phase 2

A Platform Study of Novel Immunotherapy Combinations as First-Line Treatment in Participants With PD-L1 Positive Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck- GALAXIES H&N-202

Active Not Recruiting
NCT06567782Phase 2

A Study of Neoadjuvant Dostarlimab Plus Capecitabine Plus Oxaliplatin (CAPEOX) Vs CAPEOX With Previously Untreated T4N0 or Stage III Mismatch Repair Proficient (MMRp)/Microsatellite Stable (MSS) Colon Cancer

Recruiting
NCT05870761Phase 2

Combination Niraparib and Dostarlimab Therapy for Recurrent or Persistent Uterine Serous Carcinoma

Active Not Recruiting
NCT05277051Phase 1

First-Time-in-Human Study of GSK4381562 in Participants With Advanced Solid Tumors

Active Not Recruiting
NCT04387084Phase 1

Short-term Fasting Prior to PD-1/PD-L1 Inhibitor Therapy for of Advanced or Metastatic Skin Malignancy

Active Not Recruiting
NCT05819892Phase 1

Phase I Trial Testing the Safety and Tolerability of Chemoradiation Followed by Chemotherapy + Dostarlimab for Stage IIIC, Node Positive, Endometrial Cancer

Recruiting
NCT06830239Phase 2

Phase II Study of Neoadjuvant Dostarlimab in Patients With Untreated T3-4N0-2 or Stage III pMMR/MSS Resectable Colon Cancer

Recruiting
NCT04068753Phase 2

Niraparib in Combination With Dostarlimab in Patients With Recurrent or Progressive Cervix Cancer

Active Not Recruiting
NCT05700721Phase 2

Phase II Trial of the PARP Inhibitor Niraparib and PD-1 Inhibitor Dostarlimab in Patients With Advanced Cancers With Active Progressing Brain Metastases (STARLET)

Recruiting
NCT06405230Phase 1

Evaluation of Programmed Death Ligand 1 (PDL1) Response to Treatment in Extracellular Vesicles (EVs), Patient-derived Organoid (PDOs)s and Immune-marker Positron Emission Tomography (PET) Scanning in Non-small Cell Lung Cancer (NSCLC)

Recruiting
NCT04774419Phase 2

Radiation and TSR-042 (Dostarlimab) in People With Endometrial Cancer After They Receive Surgery

Recruiting
NCT07381777Phase 2

XELOX Plus DoSTARlimab Versus XELOX Alone as Consolidation Treatment After Standard Chemoradiation in pMMR/MSS or MSI-Low Locally Advanced Rectal Cancer (LARC) Patients

Not Yet Recruiting
NCT05855200Phase 3

Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer

Recruiting
NCT04544995Phase 1

Dose Escalation and Cohort Expansion Study of Niraparib and Dostarlimab in Paediatric Participants With Solid Tumors (SCOOP)

Terminated
NCT06879717Phase 1

A Study of Roginolisib (IOA-244) in Combination With Dostarlimab With or Without Docetaxel in Metastatic Non Small-cell Lung Cancer (NSCLC) Patients

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
75